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Inflammatory response in the mid colon of ICR mice treated with polystyrene microplastics for two weeks
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Researchers found that two weeks of oral polystyrene microplastic exposure in ICR mice induced an inflammatory response specifically in the mid colon, suggesting microplastics may contribute to colonic inflammation.
Therefore, the present study suggests that PS-MPs can be a novel cause of an inflammatory response in the mid colon of ICR mice.
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Influence of Microplastics on Morphological Manifestations of Experimental Acute Colitis
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Researchers fed polystyrene microplastics to mice for six weeks and found that healthy mice developed changes in their colon lining, including altered mucus composition and immune cell populations. When mice with experimentally induced colitis also consumed microplastics, their intestinal inflammation was significantly more severe. The study suggests that microplastic exposure may worsen inflammatory bowel conditions.
Oral administration of polystyrene microplastics for 2 weeks induces chronic constipation in ICR mice
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Researchers found that feeding mice polystyrene microplastics orally for two weeks caused chronic constipation by reducing gut motility and altering intestinal neuromuscular function. The results provide direct experimental evidence that microplastic ingestion can disrupt digestive health in mammals.
Microplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis
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Mice that consumed low doses of polystyrene microplastics showed signs of colon inflammation and experienced prolonged viral arthritis symptoms. The results suggest that microplastic ingestion may worsen inflammatory conditions, though more research is needed to confirm human relevance.
Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
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Researchers exposed colitis mouse models to polystyrene micro- and nanoplastics to test whether MNP exposure worsens inflammatory bowel disease, finding that MNPs altered biodistribution and exacerbated inflammatory responses in animals with pre-existing gut inflammation.
Microplastic effects on mouse colon in normal and colitis conditions: A literature review
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This literature review examined studies on how microplastic exposure affects the mouse colon under both normal and inflammatory conditions. Evidence indicates that microplastics may contribute to intestinal inflammation and could worsen existing colitis. The review highlights the need for further research to better understand how microplastic ingestion may influence gut health in humans.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.