Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Microplastics and Nanoplastics2025
Score: 48
?
0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Verena Kopatz,
Oldamur Hollóczki,
Oldamur Hollóczki,
Oldamur Hollóczki,
Verena Kopatz,
Verena Kopatz,
Verena Kopatz,
George Sarau,
Oldamur Hollóczki,
Oldamur Hollóczki,
Verena Kopatz,
Elisabeth S. Gruber,
Elisabeth S. Gruber,
Elisabeth S. Gruber,
Oldamur Hollóczki,
Oldamur Hollóczki,
Verena Pichler,
Verena Pichler,
George Sarau,
George Sarau,
Ulrike Resch,
Ulrike Resch,
Ulrike Resch,
Silke Christiansen,
George Sarau,
George Sarau,
George Sarau,
Verena Pichler,
Verena Kopatz,
Verena Pichler,
Verena Kopatz,
Zeynab Mirzaei,
Verena Kopatz,
Verena Pichler,
Verena Pichler,
Oldamur Hollóczki,
Oldamur Hollóczki,
Verena Kopatz,
Verena Kopatz,
Verena Kopatz,
Kristina Draganic,
Zeynab Mirzaei,
Zeynab Mirzaei,
Zeynab Mirzaei,
Kristina Draganic,
Kristina Draganic,
Zeynab Mirzaei,
Zeynab Mirzaei,
Silke Christiansen,
George Sarau,
Angela Horvath,
Angela Horvath,
Angela Horvath,
Janette Pfneissl,
Verena Kopatz,
Verena Kopatz,
Verena Pichler,
Verena Kopatz,
Silke Christiansen,
Silke Christiansen,
Verena Kopatz,
Verena Kopatz,
Verena Kopatz,
George Sarau,
Janette Pfneissl,
Janette Pfneissl,
Janette Pfneissl,
Janette Pfneissl,
Michaela Schlederer,
Michaela Schlederer,
Silke Christiansen,
J Kabiljo,
Silke Christiansen,
Bernadette Mödl,
George Sarau,
J Kabiljo,
Verena Kopatz,
Verena Pichler,
Bernadette Mödl,
Gerald Timelthaler,
Julia Wallner,
Silke Christiansen,
Verena Kopatz,
Oldamur Hollóczki,
Verena Kopatz,
Bernadette Mödl,
Bernadette Mödl,
Julia Wallner,
Angela Horvath,
Angela Horvath,
Oldamur Hollóczki,
Verena Pichler,
Oldamur Hollóczki,
Wolfgang Wadsak,
Gerald Timelthaler,
Gerald Timelthaler,
Gerald Timelthaler,
Julia Wallner,
Julia Wallner,
Silke Christiansen,
Silke Christiansen,
Wolfgang Wadsak,
Verena Pichler,
Verena Pichler,
Verena Pichler,
Elisabeth S. Gruber,
Verena Pichler,
Verena Pichler,
Lukas Kenner,
Lukas Kenner,
Lukas Kenner
Julia Wallner,
Julia Wallner,
Lukas Kenner
Julia Wallner,
Julia Wallner,
Silke Christiansen,
Zeynab Mirzaei,
Julia Wallner,
Zeynab Mirzaei,
Julia Wallner,
Saule Beratlyte,
Gerald Timelthaler,
Gerald Timelthaler,
Gerald Timelthaler,
Silke Christiansen,
Zeynab Mirzaei,
Zeynab Mirzaei,
Elisabeth S. Gruber,
Zeynab Mirzaei,
Oldamur Hollóczki,
Oldamur Hollóczki,
Saule Beratlyte,
Zeynab Mirzaei,
Zeynab Mirzaei,
Wolfgang Wadsak,
Zeynab Mirzaei,
Saule Beratlyte,
Lukas Kenner
Saule Beratlyte,
Saule Beratlyte,
Saule Beratlyte,
Michaela Schlederer,
Nikola Zlatkov Kolev,
Wolfgang Wadsak,
Lukas Kenner,
Saule Beratlyte,
Saule Beratlyte,
Nikola Zlatkov Kolev,
George Sarau,
Verena Kopatz,
Verena Kopatz,
Oldamur Hollóczki,
Michaela Schlederer,
Michaela Schlederer,
Michaela Schlederer,
Oldamur Hollóczki,
Michaela Schlederer,
Verena Kopatz,
Stefan Sarbu,
Verena Pichler,
Stefan Sarbu,
Stefan Sarbu,
George Sarau,
Stefan Sarbu,
Martin Raigel,
Stefan Sarbu,
Verena Pichler,
Martin Raigel,
Stefan Sarbu,
Simina Laslau,
Simina Laslau,
Simina Laslau,
Simina Laslau,
Simina Laslau,
Oldamur Hollóczki,
Simina Laslau,
Ulrike Resch,
Oldamur Hollóczki,
Oldamur Hollóczki,
Silke Christiansen,
Martin Raigel,
Martin Raigel,
Martin Raigel,
Iris Kufferath,
Martin Raigel,
Martin Raigel,
Elisabeth S. Gruber,
Elisabeth S. Gruber,
Wolfgang Wadsak,
George Sarau,
Elisabeth S. Gruber,
J. Widder,
J. Widder,
J. Widder,
J. Widder,
Silke Christiansen,
George Sarau,
Iris Kufferath,
Iris Kufferath,
Silke Christiansen,
Iris Kufferath,
Marion J. Pollheimer,
Nikola Zlatkov Kolev,
Marion J. Pollheimer,
Marion J. Pollheimer,
Marion J. Pollheimer,
Marion J. Pollheimer,
Marion J. Pollheimer,
Nikola Zlatkov Kolev,
Wolfgang Wadsak,
Wolfgang Wadsak,
Robert Eferl,
George Sarau,
George Sarau,
Silke Christiansen,
Silke Christiansen,
Silke Christiansen,
Nikola Zlatkov Kolev,
Verena Pichler,
Nikola Zlatkov Kolev,
Nikola Zlatkov Kolev,
Nikola Zlatkov Kolev,
Nikola Zlatkov Kolev,
Nikola Zlatkov Kolev,
Marcus Krueger,
Marcus Krueger,
Marcus Krueger,
Marcus Krueger,
Marcus Krueger,
Marcus Krueger,
Robert Eferl,
Robert Eferl,
Robert Eferl,
G Egger,
G Egger,
Vanessa Stadlbauer,
Vanessa Stadlbauer,
Vanessa Stadlbauer,
Verena Pichler,
Verena Pichler,
Verena Pichler,
Lukas Kenner
Lukas Kenner,
Lukas Kenner,
Lukas Kenner
Summary
Researchers induced colitis in mice using dextran sodium sulfate and orally administered polystyrene micro- and nanoplastics of three sizes, then tracked biodistribution, macrophage polarization, and gut microbiome changes. In colitis conditions, microplastic uptake into systemic tissues was enhanced, macrophages shifted toward a pro-inflammatory phenotype, and gut microbial diversity decreased, suggesting that inflammatory bowel disease increases vulnerability to microplastic-driven systemic harm.
The increasing prevalence of inflammatory bowel disease (IBD) and rising pollution from micro- and nanoplastic (MNP) particles has prompted investigations on their potential interconnection. To elucidate the complex relationship between IBD and exposure to MNPs, we induced colitis in mice using dextran sodium sulfate (DSS) and orally administered a mixture of polystyrene (PS) MNPs (diameter 10, 1, and 0.29 µm). These particles enabled a detailed examination of MNP biodistribution, innate immune cell response and gut microbiome alterations under inflammatory conditions. Specifically, the nanosized PS particles predominantly accumulated in the bloodstream and excretory organs, with enhanced accumulation in the inflamed gut/colon. Proteomic analysis of the colon revealed alterations in molecular pathways related to protein transport, metabolism, and immune responses. Specifically, we found macrophage proteome signatures with pro-inflammatory polarization, highlighting the intricate effects of MNPs on inflammation and immune cell behavior. Moreover, MNPs significantly disrupted the gut microbiome, reducing microbial diversity and shifting bacterial populations towards pro-inflammatory and potentially pathogenic species. These changes suggest that MNP exposure could exacerbate colitis through complex interactions involving MNPs, immune responses, and microbial dynamics. The widespread presence of MNPs underscores the urgent need for comprehensive strategies to address MNP pollution, its implications for disease, and potential impacts on public health.