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61,005 resultsShowing papers similar to Distinct accumulation of nanoplastics in human intestinal organoids
ClearBiological effects of polystyrene micro- and nano-plastics on human intestinal organoid-derived epithelial tissue models without and with M cells.
Researchers exposed human intestinal organoid-derived epithelial tissue models with and without M cells to polystyrene micro- and nano-plastics, finding that nano-plastics caused greater disruption of barrier integrity and uptake than micro-plastics, and that M cell-containing models showed enhanced particle translocation compared to standard epithelial models.
Nanoplastics as a potential environmental health factor: effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells
Researchers tested how polystyrene nanoparticles interact with human intestinal cells in the lab. They found that the nanoparticles were readily taken up by the cells in a concentration-dependent manner, but no significant toxic effects were observed under the conditions tested. The study suggests that while nanoplastics can enter gut cells, their short-term toxicity at the tested levels appears limited.
Mechanisms of ingested polystyrene micro-nanoplastics (MNPs) uptake and translocation in an in vitro tri-culture small intestinal epithelium
Researchers used a sophisticated laboratory model of the human small intestine to study how micro- and nanoplastics cross the gut barrier after simulated digestion. They found that smaller nanoplastics were absorbed more efficiently than larger microplastics, and the particles used multiple cellular pathways to cross the intestinal lining. The study provides new evidence about the mechanisms by which ingested plastic particles could potentially reach the bloodstream.
Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo
Researchers studied the uptake and effects of orally ingested polystyrene microplastic particles using human intestinal cell models and rodent experiments. They found that smaller microplastics were taken up by intestinal cells and could cross the gut barrier, though the majority passed through the digestive system. The study suggests that while most ingested microplastics are excreted, a fraction can be absorbed, warranting further investigation into long-term health effects.
Interactions of polystyrene nanoplastics with in vitro models of the human intestinal barrier
Researchers assessed the effects of polystyrene nanoparticles on two in vitro models simulating the human intestinal barrier and its associated immune system. The study found that while cell viability and membrane integrity were largely maintained, the nanoparticles were able to interact with and translocate across the intestinal cell layers, raising questions about potential long-term exposure effects.
Long-Term Effects of Polystyrene Nanoplastics in Human Intestinal Caco-2 Cells
Researchers exposed human intestinal cells to polystyrene nanoplastics over an extended period to simulate chronic dietary exposure. They found that long-term exposure at low concentrations caused subtle but persistent changes in cell function, including altered gene expression and increased oxidative stress markers. The study highlights that the health effects of nanoplastics may build up gradually over time, underscoring the importance of studying chronic rather than just short-term exposure.
Bioaccumulation of differently-sized polystyrene nanoplastics by human lung and intestine cells
Researchers examined how human lung and intestine cells take up polystyrene nanoplastics of different sizes, finding that smaller particles were internalized in greater numbers but at lower total mass compared to larger ones. When compared on a surface area basis, the uptake rates were similar across sizes, suggesting that surface interactions with cell membranes play a key role. The findings indicate that particle size is an important factor to consider when evaluating the health risks of nanoplastic exposure.
Impact of food matrices on the characteristics and cellular toxicities of ingested nanoplastics in a simulated digestive tract
Researchers investigated how different food components affect the toxicity of polystyrene nanoplastics as they pass through a simulated human digestive system. They found that fat molecules helped stabilize and disperse the nanoplastics during digestion, increasing their uptake by intestinal cells and worsening cellular damage. The study suggests that the type of food consumed alongside nanoplastic-contaminated items could significantly influence how much harm the particles cause in the gut.
Effects of bisphenol A and nanoscale and microscale polystyrene plastic exposure on particle uptake and toxicity in human Caco-2 cells
Researchers studied how human intestinal Caco-2 cells take up polystyrene plastic particles of five different sizes ranging from 300 nanometers to 6 micrometers. The study found that smaller particles were taken up at higher rates and that co-exposure with bisphenol A increased cellular toxicity, suggesting that nanoscale plastics may pose a greater risk to human intestinal cells than larger microplastics.
The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
Researchers studied how the human digestive process changes the physical and biological properties of polystyrene nanoplastics. They found that digestive fluids altered the surface characteristics of the particles, potentially affecting how they interact with gut cells. The study suggests that the form of nanoplastics that actually reaches our intestines may behave differently than the pristine particles typically used in lab studies.
Polystyrene nanoplastics disrupt the intestinal microenvironment by altering bacteria-host interactions through extracellular vesicle-delivered microRNAs
Researchers found that polystyrene nanoplastics disrupt the gut lining in mice by altering tiny RNA molecules that control the production of protective proteins in the intestinal barrier. The nanoplastics also caused an imbalance in gut bacteria, creating a chain reaction where damaged gut cells release particles that further weaken the intestinal barrier and change the microbiome.
Nano-plastics and gastric health: Decoding the cytotoxic mechanisms of polystyrene nano-plastics size
Researchers examined how different sizes of polystyrene nanoplastics affect human stomach cells in the laboratory. They found that smaller nanoplastics were more readily taken up by the cells and caused greater damage, including increased oxidative stress and reduced cell survival. The study suggests that nanoplastic particle size plays a critical role in determining their potential impact on gastrointestinal health.
The effects of polystyrene microplastics on human intestinal cells health and function
This study examined how polystyrene microplastics affect normal and cancer intestinal cells, addressing a gap left by previous research that used only cancer cell lines and pristine plastics. The work evaluated microplastic toxicity under more realistic conditions including digestive system biotransformation, assessing effects on nutrient uptake and cellular function.
Ingested nano- and microsized polystyrene particles surpass the intestinal barrier and accumulate in the body
Researchers fed mice nano- and microsized polystyrene particles for up to 24 weeks to study intestinal barrier crossing and accumulation. The study found that plastic particles accumulated in the small intestine and distant organs, though they did not promote intestinal inflammation or worsen colitis, while noting that long-term accumulative effects on gastrointestinal health cannot be ruled out.
Tissue distribution of polystyrene nanoplastics in mice and their entry, transport, and cytotoxicity to GES-1 cells
Scientists tracked polystyrene nanoplastics in mice after oral exposure and found the particles accumulated in the stomach, intestines, and liver tissues. In human gastric cells, the nanoplastics entered through multiple pathways and were transported through the cell's internal trafficking system, ultimately reducing cell growth and increasing cell death. The study provides detailed evidence of how nanoplastics can cross biological barriers and cause cellular damage in mammalian systems.
Autophagic response of intestinal epithelial cells exposed to polystyrene nanoplastics
Researchers found that polystyrene nanoplastics accumulate in the cytoplasm of intestinal epithelial cells, impairing autophagic flux and triggering an autophagic stress response confirmed in both cell and animal models.
Investigations of acute effects of polystyrene and polyvinyl chloride micro- and nanoplastics in an advanced in vitro triple culture model of the healthy and inflamed intestine
Researchers tested the acute toxicity of polystyrene and polyvinyl chloride micro- and nanoparticles using an advanced triple-culture model of the human intestinal barrier, including both healthy and inflamed conditions. They found that the plastic particles did not cause significant acute toxicity at the concentrations tested, though the inflamed intestinal model showed greater particle uptake. The study suggests that while short-term exposure may not cause immediate damage, chronic exposure and pre-existing inflammation could influence how the body handles ingested microplastics.
Utilization of intestinal organoid models for assessment of micro/nano plastic-induced toxicity
This review examines the use of intestinal organoid models as a more physiologically accurate alternative to traditional cell cultures and animal experiments for studying micro- and nanoplastic toxicity. Researchers highlight that organoids can mimic the complex structure of intestinal tissue, providing better insight into how plastic particles affect the gut. The study suggests that while organoid-based research is still in its early stages, it holds significant promise for advancing our understanding of plastic-related health effects.
The potential effects of microplastic pollution on human digestive tract cells
Researchers tested polystyrene particles of four different sizes on human colon and small intestine cells to assess the potential effects of microplastic ingestion. They found that the smallest nanoscale particles were more readily taken up by cells and caused greater reductions in cell viability and increased oxidative stress. The study suggests that smaller plastic particles may pose a greater risk to the human digestive tract than larger ones.
Uptake and effects of polystyrene nanoplastics in comparison to non-plastic silica nanoparticles on small intestine cells (IPEC-J2)
Researchers exposed small intestine cells to 100 nm polystyrene nanoplastics and found the particles were taken up by cells and significantly altered the TP53 and NOTCH signaling pathways — key regulators of cell survival and growth — raising concerns about how nanoplastics ingested through food might affect gut cell function.
Comparative evaluation of molecular mechanisms triggered by differently functionalized polystyrene nanoplastics in human colon cell lines
Researchers compared the molecular mechanisms triggered by polystyrene nanoplastics with different surface functionalization in human colon cell lines. The study examined how surface chemistry of nanoplastic particles influences their biological interactions with intestinal cells, contributing to understanding of how nanoplastics may affect the human gastrointestinal system.
A Comparative Systematic Analysis of The Influence of Microplastics on Colon Cells, Mouse and Colon Organoids
Researchers compared microplastic effects across colon cells, mouse models, and colon organoids, finding that microplastic ingestion can induce tissue damage and alter cellular function in the digestive system, with organoids providing a valuable intermediate testing platform.
Fate, uptake and impact of fit-for-purpose nanoplastics on the digestive environment: an in vitro-in vivo continuum study
Researchers used fluorescently and gold-labeled polystyrene nanoplastics as models to study how these particles behave in the digestive environment and what effects they have on gut health. The study revealed that nanoplastics interact with the digestive system in ways that depend on particle labeling and surface properties.
Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro
Researchers assessed the toxicity and transport of polystyrene nano- and microparticles using multiple human cell models, including intestinal and placental barrier systems. They found that while neither size was acutely toxic, the nanoparticles were able to cross the intestinal barrier and showed some embryotoxic potential. The study suggests that nanoplastics may pose greater health concerns than microplastics due to their ability to penetrate biological barriers.