Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Nanoplastics Sign in to save

Impact of food matrices on the characteristics and cellular toxicities of ingested nanoplastics in a simulated digestive tract

Food and Chemical Toxicology 2023 24 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Boxuan Liang, Boxuan Liang, Boxuan Liang, Boxuan Liang, Yizhou Zhong, Zhiming Li, Qing Wang, Zhiming Li, Zhiming Li, Qing Wang, Zhenlie Huang, Qing Wang, Yizhou Zhong, Yizhou Zhong, Zhiming Li, Qing Wang, Qing Wang, Qing Wang, Yizhou Zhong, Yizhou Zhong, Boxuan Liang, Boxuan Liang, Yizhou Zhong, Boxuan Liang, Boxuan Liang, Boxuan Liang, Boxuan Liang, Boxuan Liang, Boxuan Liang, Boxuan Liang, Boxuan Liang, Yuji Huang, Yuji Huang, Boxuan Liang, Boxuan Liang, Zhiming Li, Yuji Huang, Yuji Huang, Yuji Huang, Yuji Huang, Yuji Huang, Boxuan Liang, Boxuan Liang, Zhiming Li, Yizhou Zhong, Yizhou Zhong, Qing Wang, Boxuan Liang, Yuji Huang, Qing Wang, Yizhou Zhong, Boxuan Liang, Yizhou Zhong, Zhiming Li, Yuji Huang, Qing Wang, Yuji Huang, Yuji Huang, Yuji Huang, Yizhou Zhong, Yuji Huang, Yizhou Zhong, Qing Wang, Yuji Huang, Yuji Huang, Yuji Huang, Yuji Huang, Yizhou Zhong, Zhiming Li, Yizhou Zhong, Yizhou Zhong, Qing Wang, Zhiming Li, Yizhou Zhong, Yuji Huang, Yizhou Zhong, Yizhou Zhong, Yuji Huang, Yuji Huang, Yuji Huang, Yuji Huang, Qing Wang, Boxuan Liang, Yuji Huang, Boxuan Liang, Yizhou Zhong, Yizhou Zhong, Boxuan Liang, Haixia Sui, Yizhou Zhong, Yizhou Zhong, Yizhou Zhong, Yizhou Zhong, Zhiming Li, Zhiming Li, Qing Wang, Qing Wang, Zhiming Li, Qing Wang, Yizhou Zhong, Zhiming Li, Yizhou Zhong, Yizhou Zhong, Yuji Huang, Yizhou Zhong, Boxuan Liang, Haixia Sui, Haixia Sui, Qing Wang, Yuji Huang, Zhiming Li, Qing Wang, Qing Wang, Zhiming Li, Boxuan Liang, Yuji Huang, Boxuan Liang, Boxuan Liang, Haixia Sui, Qing Wang, Qing Wang, Boxuan Liang, Yuji Huang, Xingfen Yang Boxuan Liang, Boxuan Liang, Haixia Sui, Yuji Huang, Haixia Sui, Qing Wang, Haixia Sui, Yizhou Zhong, Yizhou Zhong, Boxuan Liang, Yuji Huang, Yuji Huang, Xingfen Yang Xingfen Yang Qing Wang, Qing Wang, Qing Wang, Qing Wang, Qing Wang, Qing Wang, Qing Wang, Zhiming Li, Zhiming Li, Zhenlie Huang, Haixia Sui, Yizhou Zhong, Yizhou Zhong, Boxuan Liang, Yuji Huang, Yuji Huang, Boxuan Liang, Qing Wang, Zhiming Li, Boxuan Liang, Qing Wang, Haixia Sui, Qing Wang, Boxuan Liang, Haixia Sui, Haixia Sui, Yizhou Zhong, Qing Wang, Yizhou Zhong, Yizhou Zhong, Haixia Sui, Yizhou Zhong, Xingfen Yang Boxuan Liang, Qing Wang, Zhenlie Huang, Haixia Sui, Yuji Huang, Qing Wang, Qing Wang, Qing Wang, Yuji Huang, Haixia Sui, Qing Wang, Qing Wang, Boxuan Liang, Boxuan Liang, Boxuan Liang, Qing Wang, Boxuan Liang, Qing Wang, Yizhou Zhong, Qing Wang, Yizhou Zhong, Yuji Huang, Yuji Huang, Yuji Huang, Qing Wang, Yuji Huang, Qing Wang, Yuji Huang, Qing Wang, Yuji Huang, Qing Wang, Yuji Huang, Qing Wang, Qing Wang, Boxuan Liang, Yizhou Zhong, Xingfen Yang Qing Wang, Boxuan Liang, Xingfen Yang Qing Wang, Xingfen Yang Yizhou Zhong, Xingfen Yang Zhenlie Huang, Boxuan Liang, Yuji Huang, Yuji Huang, Boxuan Liang, Haixia Sui, Zhenlie Huang, Zhenlie Huang, Haixia Sui, Zhenlie Huang, Zhiming Li, Haixia Sui, Xingfen Yang Xingfen Yang Yizhou Zhong, Yizhou Zhong, Yizhou Zhong, Yizhou Zhong, Haixia Sui, Haixia Sui, Haixia Sui, Xingfen Yang Xingfen Yang Zhenlie Huang, Zhenlie Huang, Xingfen Yang Zhenlie Huang, Zhenlie Huang, Xingfen Yang Qing Wang, Zhenlie Huang, Xingfen Yang Boxuan Liang, Xingfen Yang Xingfen Yang Boxuan Liang, Zhenlie Huang, Xingfen Yang Xingfen Yang Zhenlie Huang, Zhenlie Huang, Zhenlie Huang, Zhenlie Huang, Zhenlie Huang, Xingfen Yang Zhenlie Huang, Zhenlie Huang, Zhenlie Huang, Zhenlie Huang, Zhenlie Huang, Qing Wang, Xingfen Yang

Summary

Researchers investigated how different food components affect the toxicity of polystyrene nanoplastics as they pass through a simulated human digestive system. They found that fat molecules helped stabilize and disperse the nanoplastics during digestion, increasing their uptake by intestinal cells and worsening cellular damage. The study suggests that the type of food consumed alongside nanoplastic-contaminated items could significantly influence how much harm the particles cause in the gut.

Polymers

Body Systems

Digestive Immune

Study Type In vitro

Microplastic and nanoplastic (MNP) pollution has become a major global food safety concern. MNPs can interact with food matrices, and their passage through the gastrointestinal tract can modify their properties. To explore whether and how food matrices influence MNP toxicity, we investigated the interactions between polystyrene nanoplastics (PS-NPs) and food matrices, using an in vitro gastrointestinal digestion model. Then, we tested cell viability, particle uptake and cellular toxicities induced by PS-NPs with food matrices in Caco-2 cells. The results showed that PS-NPs were aggregated, both with and without food matrices, after in vitro gastrointestinal digestion. Glyceryl trioleate exerted greater ability to stabilize digestas and to disperse PS-NPs than starch and bovine serum albumin. The protein corona's protein composition on PS-NPs varied when it interacted with different food matrices. Moreover, when combined with food matrices, the PS-NPs' uptake was enhanced, thus aggravating cellular inflammation, stress, and apoptosis levels. Finally, through co-exposure to a mixture of food matrices, we found a combined negative effect of PS-NPs and cadmium on cellular inflammation, stress, and apoptosis levels. This is the first study to compare the impact of various food matrices on the characteristics and cellular toxicities of ingested NPs in a simulated digestive tract.

Read via DOI PubMed

Share this paper

Post Share Share Pin Email