We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
20 resultsShowing papers similar to Empirical antibiotics of non-carbapenems for ESBL-producing E. coli and K. pneumoniae bacteremia in children : a retrospective medical record review
ClearInitial empirical antibiotics of non-carbapenems for ESBL-producing E. coli and K. pneumoniae bacteremia in children: a retrospective medical record review
Researchers reviewed medical records of children with bloodstream infections from antibiotic-resistant bacteria and found that starting with non-carbapenem antibiotics — a broader, less powerful class — did not increase mortality risk as long as treatment was quickly adjusted once lab results confirmed the specific bacteria involved.
Differential survival of potentially pathogenic, septicemia- and meningitis-causing E. coli across the wastewater treatment train
Researchers screened E. coli isolates from Canadian wastewater treatment plant effluents and found that 86 isolates carried virulence markers characteristic of extraintestinal pathogenic E. coli (ExPEC) strains capable of causing septicemia and meningitis. Many isolates belonged to pandemic lineages (ST131, ST95, ST73) and survived chlorination, indicating that conventional wastewater treatment does not adequately eliminate clinically important pathogenic E. coli.
Understanding the clinical and molecular epidemiological characteristics of carbapenem-resistant Acinetobacter baumannii infections within intensive care units of three teaching hospitals
Researchers analyzed carbapenem-resistant Acinetobacter baumannii (CRAB) — a dangerous antibiotic-resistant bacterium — in intensive care units across three hospitals and found it is common and growing increasingly resistant over time. Early identification and aggressive management are critical to stopping its spread in hospital settings.
Multidrug-resistant Escherichia coli causing diarrhea in yak calves on the Qinghai-Tibet Plateau: phenotypic characterization, whole-genome sequencing, and pathogenicity analysis
Scientists found dangerous, drug-resistant E. coli bacteria in sick yak calves in Tibet that doesn't respond to most common antibiotics. These "superbug" strains could potentially spread to humans through the food chain or environment, making infections much harder to treat. This highlights the growing global threat of antibiotic-resistant bacteria, especially in areas where antibiotics are used heavily in livestock.
Occurrence of EBSL and quinolone resistance genes among Escherichia coli and Klebsiella pneumoniae isolated from poultry, domestic pigs and environment in the Msimbazi River Basin in Tanzania
Researchers investigated the occurrence and distribution of extended-spectrum beta-lactamase (ESBL) and plasmid-mediated quinolone resistance genes in multi-drug-resistant Escherichia coli and Klebsiella pneumoniae isolated from poultry, domestic pigs, and environmental samples in the Msimbazi River Basin, Tanzania. Screening 110 isolates for CTX-M, TEM, SHV, qnrA, qnrB, and qnrS genes revealed widespread resistance gene carriage across animal and environmental sources.
Driving Antibiotic Resistance Evolution of E. coli by Three Commonly Used Disinfectants Under Concentration-Increasing Stress
Scientists found that three common disinfectants (including those used in hospitals and cleaning products) can make E. coli bacteria become resistant to both the disinfectants themselves and important antibiotics when exposed to low concentrations over time. This means that leftover disinfectant residues in our environment might be helping create "superbug" bacteria that are harder to treat with medicines. The findings suggest we need to be more careful about how we use and dispose of disinfectants to prevent creating more antibiotic-resistant infections.
Antibiotic Resistance Pattern in Intensive Care Unit Patients of Bangladesh
This observational study examined antibiotic resistance patterns in intensive care unit patients at a hospital in Bangladesh, characterizing the organisms and resistance profiles of infections in critically ill patients. The study found high rates of multi-drug resistance among ICU pathogens, with implications for empirical treatment protocols in resource-limited settings.
Pathogenic Escherichia coli Strains Recovered from Selected Aquatic Resources in the Eastern Cape, South Africa, and Its Significance to Public Health
Researchers recovered pathogenic Escherichia coli strains from aquatic environments in the Eastern Cape of South Africa, finding evidence of antimicrobial resistance genes and highlighting the public health significance of waterway contamination as a pathway for resistance proliferation.
Potential of waterbodies as a reservoir ofEscherichia colipathogens and the spread of antibiotic resistance in the Indonesian aquatic environment
This review analyzes the factors driving the spread of pathogenic Escherichia coli and antibiotic-resistant bacteria in Indonesian aquatic environments, including antibiotic misuse, inadequate waste treatment, and poor industrial waste management. Indonesian rivers serve as vectors for both pathogenic E. coli and antimicrobial resistance genes, posing significant public health risks.
Evaluation of the Genetic Diversity of Antibiotic-Resistant Klebsiella Pneumoniae Isolated from Diarrheal Humans and Poultry using Multilocus Sequence Typing
Researchers evaluated the genetic diversity of antibiotic-resistant Klebsiella pneumoniae isolates from diarrheal human patients and poultry in Iraq using multilocus sequence typing of four housekeeping genes, finding high antibiotic resistance rates -- 100% resistance to ampicillin -- and genetic overlap between human and poultry isolates, suggesting possible cross-species transmission.
Hidden threats in the plastisphere: Carbapenemase-producing Enterobacterales colonizing microplastics in river water
Researchers placed microplastics in a river near a wastewater treatment plant and found that antibiotic-resistant bacteria, including dangerous carbapenem-resistant strains, colonized the plastic surfaces. These bacteria carried multiple drug-resistance genes and virulence traits, making them potential threats to human health. The study demonstrates that microplastics in waterways can serve as floating platforms that help spread antibiotic-resistant superbugs from wastewater into the broader environment.
Panel data analysis of spatial effects carbapenem-resistant organisms in mainland China
Researchers analyzed antibiotic-resistant "superbug" infection rates across 30 Chinese provinces over nearly a decade, finding that carbapenem-resistant bacteria cluster geographically and spread to neighboring regions. Urbanization, healthcare density, and pollution from pesticides and particulate matter (PM2.5) all contributed to the spread, highlighting the need for coordinated cross-regional strategies to contain antibiotic resistance.
Multiple Bacterial Strategies to Survive Antibiotic Pressure: A Review
This review examined multiple bacterial strategies for surviving antibiotic pressure, including genetic mutations, efflux pumps, biofilm formation, and horizontal gene transfer, highlighting how resistance reservoirs exist beyond hospital settings.
Transmission and Evolution of Antibiotic Resistance Genes and Antibiotic-Resistant Bacteria in Animals, Food, Humans and the Environment
This research review shows that antibiotic-resistant bacteria and their genes are now found everywhere—in people, animals, food, and the environment—not just in hospitals like we used to think. The bacteria can easily share their resistance genes with each other, allowing "superbugs" to spread rapidly between different environments. This matters because it means antibiotic-resistant infections are becoming harder to treat and can reach us through multiple pathways, making it crucial to tackle this problem across all areas of health and the environment at once.
Antibiotic Resistance Mediated by Escherichia coli in Kuwait Marine Environment as Revealed through Genomic Analysis
Researchers used genomic analysis to identify antibiotic resistance genes in Escherichia coli isolated from mollusks and coastal water samples in Kuwait's marine environment. The study found that Kuwait's coastal waters, vulnerable to sewage contamination from storm outlets and waste disposal, harbor E. coli carrying multiple antibiotic resistance gene elements including integrons and plasmids.
Microplastics in marine pollution: Oceanic hitchhikers for the global dissemination of antimicrobial-resistant bacteria
This review examines how marine microplastics serve as surfaces for biofilm formation by bacteria, including carbapenem-resistant strains, enabling the global dissemination of antimicrobial-resistant bacteria through ocean currents. The authors highlight the plastisphere as an understudied vector for spreading antibiotic resistance genes across marine environments.
The Travelling Particles: Investigating microplastics as possible transport vectors for multidrug resistant E. coli in the Weser estuary (Germany)
Scientists tested whether microplastics in the Weser estuary in Germany carry multidrug-resistant ESBL-producing E. coli, finding resistant bacteria on plastic surfaces at concentrations above surrounding water, confirming that microplastics can serve as vectors for antibiotic-resistant pathogens.
An approach for deriving water quality guideline values for antimicrobials that integrates ecotoxicity and antimicrobial resistance endpoints
Researchers developed an approach for setting water quality guideline values for antimicrobials in Australia and New Zealand that integrates both direct ecotoxicity endpoints and antimicrobial resistance endpoints, addressing a gap in current frameworks that do not account for resistance-promoting environmental concentrations.
Variability of bile bacterial profiles and drug resistance in patients with choledocholithiasis combined with biliary tract infection: a retrospective study
This retrospective study examined changing patterns of bacterial infections in bile from patients with bile duct stones and biliary tract infections. Researchers found that gram-positive bacterial infections have been increasing over time, while gram-negative bacteria including E. coli have become less common. The findings suggest that antibiotic treatment for these infections should be tailored to reflect current local bacterial profiles.
Environmental concentrations of antibiotics, biocides, and heavy metals fail to induce phenotypic antimicrobial resistance in Escherichia coli
Researchers found that environmental concentrations of antibiotics, biocides, and heavy metals did not induce phenotypic antimicrobial resistance in E. coli over a 30-day exposure period, suggesting low-level pollutant mixtures may not drive resistance development as previously feared.