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61,005 resultsShowing papers similar to Microplastics and their Additives in the Indoor Environment
ClearMultiomics analysis revealed the effects of polystyrene nanoplastics at different environmentally relevant concentrations on intestinal homeostasis
Researchers fed mice polystyrene nanoplastics at three different doses for 42 days and used multiple analysis methods to study the effects on gut health. Even the lowest dose increased gut permeability (leaky gut), triggered inflammation, and disrupted the balance of gut bacteria and their metabolites. These findings suggest that environmentally realistic levels of nanoplastic exposure could harm intestinal health and potentially contribute to chronic gut problems.
Interactions between polystyrene-derived micro- and nanoplastics and the microbiota: a systematic review of multi-omics mouse studies
Researchers systematically reviewed 15 mouse studies and found that exposure to polystyrene micro- and nanoplastics consistently disrupted gut bacteria — reducing beneficial species like Lactobacillus and increasing harmful ones — while also altering metabolic pathways throughout the body. Nanoplastics caused more severe microbiome disruption than larger microplastics, highlighting a serious health concern for humans.
Effects of partial reduction of polystyrene micro-nanoplastics on the immunity, gut microbiota and metabolome of mice
This mouse study examined whether partial gut degradation of polystyrene micro- and nanoplastics affects immune markers, gut microbiota, and metabolome, finding that nanoplastic exposure produced distinct immune and microbial changes compared to microplastic exposure. Notably, different exposure doses shifted the key bacterial species stabilizing gut microbial networks.
The role of gut microbiota in mediating increased toxicity of nano-sized polystyrene compared to micro-sized polystyrene in mice
This mouse study found that nano-sized polystyrene plastics were significantly more toxic than micro-sized ones, causing greater gut inflammation, liver damage, and metabolic disruption. The key difference was driven by how each size affected gut bacteria: nanoplastics caused a more severe shift toward harmful bacteria and away from beneficial ones. The findings suggest that the smallest plastic particles may pose the greatest health risk because they more dramatically disrupt the gut microbiome.
Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice
Researchers exposed mice to polystyrene microplastics for six weeks and found that the particles accumulated in the gut, reduced protective mucus secretion, and damaged the intestinal barrier. The microplastics also significantly altered the composition of gut bacteria, decreasing beneficial species and increasing harmful ones. The study suggests that microplastic ingestion could disrupt gut health in mammals by simultaneously impairing the physical barrier and reshaping the microbiome.
Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice
Researchers fed mice two sizes of polystyrene microplastics for five weeks and observed significant disruption of gut bacteria and changes in liver fat metabolism. The microplastics decreased mucus production in the gut and shifted the balance of key bacterial populations at multiple taxonomic levels. The study suggests that microplastic ingestion can trigger gut microbiota imbalance in mammals, which may in turn affect metabolic health.
Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Researchers exposed colitis mouse models to polystyrene micro- and nanoplastics to test whether MNP exposure worsens inflammatory bowel disease, finding that MNPs altered biodistribution and exacerbated inflammatory responses in animals with pre-existing gut inflammation.
Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Researchers induced colitis in mice using dextran sodium sulfate and orally administered polystyrene micro- and nanoplastics of three sizes, then tracked biodistribution, macrophage polarization, and gut microbiome changes. In colitis conditions, microplastic uptake into systemic tissues was enhanced, macrophages shifted toward a pro-inflammatory phenotype, and gut microbial diversity decreased, suggesting that inflammatory bowel disease increases vulnerability to microplastic-driven systemic harm.
Gut Check: Microbiota and Obesity in Mice Exposed to Polystyrene Microspheres
Researchers found that gut microbiota appeared to play a mediating role in the obesity outcomes observed in mice fed manufactured polystyrene microspheres, suggesting that microplastic-induced alterations to the gut microbiome may be a mechanism linking microplastic exposure to metabolic dysfunction and weight gain.
Long-term exposure to polystyrene microplastics promotes HFD-induced obesity in mice through exacerbating microbiota dysbiosis
Researchers found that long-term polystyrene microplastic exposure worsened high-fat-diet-induced obesity in mice by exacerbating gut microbiota dysbiosis, suggesting microplastic ingestion may amplify metabolic disease risk through disruption of the gut microbiome.
Polystyrene micro- and nanoparticles exposure induced anxiety-like behaviors, gut microbiota dysbiosis and metabolism disorder in adult mice
A mouse study found that exposure to both micro- and nano-sized polystyrene particles caused anxiety-like behavior, disrupted gut bacteria, and altered metabolism. The nanoplastics caused more severe effects than the larger microplastics, and longer exposure periods made the damage worse. These findings support the idea that plastic particles can affect brain function and behavior through the gut-brain connection.
Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Researchers found that polystyrene micro- and nanoplastics aggravated colitis symptoms in a mouse model, increasing gut permeability, inflammatory cytokine levels, and tissue damage compared to controls. The study provides mechanistic evidence linking microplastic exposure to worsening of inflammatory bowel conditions.
Oral exposure to high concentrations of polystyrene microplastics alters the intestinal environment and metabolic outcomes in mice
In a mouse study, oral exposure to high concentrations of polystyrene microplastics caused fatty liver disease and abnormal blood lipid levels even without prior gut leakiness. The microplastics triggered intestinal inflammation through immune cells, disrupted gut bacteria, and altered how the body processes nutrients. These results suggest that swallowing microplastics could contribute to metabolic problems and liver disease in humans.
Microbiota-mediated metabolic perturbations in the gut and brain of mice after microplastic exposure
In a mouse study, oral exposure to polystyrene microplastics of two sizes altered the gut bacteria community and caused metabolic changes in both the intestines and the brain. The disrupted gut bacteria appeared to drive changes in bile acid, energy, and other metabolic pathways. These findings support the idea that microplastics in food and water could affect brain health indirectly by first disrupting the gut microbiome and its chemical signals.
In vivo impact assessment of orally administered polystyrene nanoplastics: biodistribution, toxicity, and inflammatory response in mice
Researchers orally administered polystyrene nanoplastics to mice for two weeks and tracked their distribution and biological effects. The nanoplastics accumulated primarily in the intestine, kidneys, and liver, triggering significant inflammatory responses and oxidative stress in these organs despite no visible tissue damage. The study provides evidence that even short-term oral exposure to nanoplastics can cause meaningful inflammatory changes in multiple organ systems.
Polystyrene microplastics trigger adiposity in mice by remodeling gut microbiota and boosting fatty acid synthesis
Researchers discovered that polystyrene microplastics at relatively low concentrations caused weight gain and excess fat accumulation in mice by reshaping their gut bacteria. The altered gut microbiome boosted fatty acid production, increased appetite, and lowered physical activity in the exposed mice. This finding is significant because it suggests everyday levels of microplastic exposure could contribute to obesity through changes in gut bacteria and metabolism.
Polystyrene microplastic exposure induces insulin resistance in mice via dysbacteriosis and pro-inflammation
Researchers found that exposing mice to polystyrene microplastics induced insulin resistance regardless of whether the animals were on a normal or high-fat diet. The study identified disruption of gut bacteria and increased intestinal inflammation as key mechanisms driving the metabolic changes. These findings suggest that microplastic exposure may contribute to metabolic health issues by altering the gut microbiome and triggering chronic inflammation.
Long-Term Exposure to Polystyrene Microspheres and High-Fat Diet-Induced Obesity in Mice: Evaluating a Role for Microbiota Dysbiosis.
A long-term mouse study examined how chronic exposure to polystyrene microspheres interacts with a high-fat diet to affect obesity-related outcomes, finding that microplastics worsened metabolic disruption and fat accumulation compared to diet alone. The results raise concern that microplastic exposure may be an environmental factor contributing to the global obesity epidemic.
Role of Nanoplastics in Decreasing the Intestinal Microbiome Ratio: A Review of the Scope of Polystyrene
This scoping review of 56 studies found consistent evidence that polystyrene nanoplastics (≤100 nm) disrupt gut homeostasis through a three-stage cascade: ROS generation and oxidative stress, intestinal barrier dysfunction, and gut microbiome dysbiosis, with downstream effects on immunity and multiple organs.
Microbiome: A forgotten target of environmental micro(nano)plastics?
This review examines how micro- and nanoplastics affect the microbiome of various organisms, an area that has received less attention than other toxicological endpoints. Researchers found that most studies focused on polystyrene particles and that exposure consistently disrupted microbiome composition, triggered immune responses, and altered enzyme activity across organisms including crustaceans, fish, and mammals. The study highlights the microbiome as an important but often overlooked target of microplastic pollution.
Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Researchers studied the effects of polystyrene micro- and nanoplastics in a mouse model of colitis, examining biodistribution, immune cell responses, and gut microbiome changes. The study found that nanosized particles in particular showed distinct biodistribution patterns and affected macrophage polarization under inflammatory conditions, suggesting that intestinal inflammation may alter how the body handles micro- and nanoplastic particles.
Airborne polystyrene microplastics and nanoplastics induce nasal and lung microbial dysbiosis in mice
Researchers found that airborne polystyrene microplastics and nanoplastics can induce microbial dysbiosis in the nasal passages and lungs of mice. The study showed that both micro- and nanoplastics altered airway microbiota composition, with microplastics having a stronger influence on lung bacterial communities, suggesting that inhaled plastic particles may disrupt respiratory microbial balance.
Integrated fecal microbiome and metabolome analysis explore the link between polystyrene nanoplastics exposure and male reproductive toxicity in mice
Researchers exposed mice to polystyrene nanoplastics of different sizes and doses, then analyzed fecal microbiome and metabolome changes alongside reproductive outcomes. The study found that nanoplastic exposure disrupted gut microbiota balance and metabolic pathways, which correlated with reduced sperm count, viability, and testosterone levels. The findings suggest that gut microbiota-metabolite disruption may play an important role in nanoplastic-induced male reproductive toxicity.
Early-life exposure to polystyrene micro- and nanoplastics disrupts metabolic homeostasis and gut microbiota in juvenile mice with a size-dependent manner
Pregnant mice given polystyrene micro or nanoplastics in their drinking water passed the particles to their pups through the placenta and breast milk, with smaller nanoplastics accumulating more heavily in organs. The nanoplastics (0.05 micrometers) caused more severe gut damage, liver dysfunction, and metabolic disruption in the young mice than the larger microplastics (5 micrometers). This study demonstrates that early-life exposure to nanoplastics, even before birth, can disrupt development in a size-dependent way, with the smallest particles posing the greatest risk.