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20 resultsShowing papers similar to Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features
ClearDetection and quantification of microplastics in various types of human tumor tissues
Researchers detected microplastics in 43% of tumor samples across lung, gastric, colorectal, cervical, and pancreatic cancers, with polystyrene, PVC, and polyethylene being the types found. In pancreatic tumors, microplastic presence was associated with fewer immune cells that fight cancer and more immune cells linked to tumor progression, suggesting microplastics may create conditions that help tumors evade the immune system.
In-silico pharmacological insights into the therapeutic potential of microRNAs for microplastic-associated cancers
Researchers systematically screened published literature to identify cancer-related genes altered by microplastic exposure, then computationally evaluated microRNAs with anticancer activity that could target those genes, finding potential miRNA-based therapeutic candidates across breast, gastric, and other microplastic-associated tumor types.
Microplastic changes during the development of cervical cancer and its effects on the metabolomic profiles of cancer tissues
Researchers found microplastics in cervical cancer tissue, with polyethylene and polypropylene being the most common types, and levels increased as the cancer progressed to more advanced stages. The microplastics appeared to alter the chemical environment within the cancer tissue, suggesting they may play a role in how cervical cancer develops, though more research is needed to confirm a causal link.
Microscopic menace: exploring the link between microplastics and cancer pathogenesis
This review examines the growing evidence linking microplastic exposure to cancer development in humans. Microplastics can accumulate in the body and trigger inflammation, oxidative stress, and other biological changes associated with tumor growth. While more clinical research is needed, the review highlights that microplastics should be taken seriously as a potential factor in cancer risk.
Microplastics as emerging carcinogens: from environmental pollutants to oncogenic drivers
This review examines growing evidence that microplastics and nanoplastics may play a role in cancer development, with these particles found in human tumor tissues from the lungs, colon, stomach, breast, and other organs. The particles appear to promote cancer through chronic inflammation, oxidative stress, DNA damage, and disruption of key cancer-related signaling pathways. While direct proof of causation in humans is still lacking, the accumulating evidence from lab studies, animal experiments, and human tissue analysis suggests microplastics deserve serious attention as potential contributors to cancer risk.
Microplastics: An emerging environmental risk factor for gut microbiota dysbiosis and cancer development?
This review examines how microplastics may disrupt the gut microbiome and immune system in ways that could promote cancer development. Evidence from recent studies suggests microplastics can cause chronic inflammation, alter the balance of gut bacteria, and trigger molecular pathways linked to several cancer types including lung, liver, breast, and colon cancer. While more human research is needed, the review highlights a concerning connection between microplastic exposure, gut health, and cancer risk.
From Exposure to Oncogenesis: the Role of Microplastics and Associated Pollutants in Cancer - a Literature Review
This literature review examined the growing evidence linking microplastic exposure to cancer development. Microplastics have been found in human lung, liver, and colon tissue, and research suggests they may promote cancer through chronic inflammation, oxidative stress, and by carrying known carcinogens like heavy metals and persistent organic pollutants into the body.
Microplastics and cancer
This review examines evidence linking microplastics to cancer risk, noting that microplastics have been detected at higher concentrations in human tumor tissues than adjacent healthy tissue, and that they can act as vectors for carcinogens while inducing oxidative stress, inflammation, and genotoxicity.
Microplastic Contamination: A Rising Environmental Crisis With Potential Oncogenic Implications
This review examines how microplastics detected in human tissues — blood, placenta, and organs — may act as vectors for carcinogens, including adsorbed heavy metals and persistent organic pollutants, and discusses emerging evidence linking MP accumulation to oncogenic processes.
The Impact of Environmental Factors on Cancer Risk: A Comprehensive Review
This paper is not about microplastics in a specific research sense; it is a broad review of how environmental factors influence cancer risk, with no substantive microplastic content evident from the available abstract.
From exposure to oncogenesis: a review on the multifaceted roles of microplastics in tumor initiation and progression
This review examined the evidence linking microplastic exposure to tumor initiation and progression, covering physical, chemical, and inflammatory mechanisms by which MPs may promote oncogenesis. The authors conclude that while current evidence is largely preclinical, accumulating data warrant serious concern about microplastics as environmental carcinogens.
The Relationship Between Microplastics and Nanoplastics with Cancer: An Emerging Health Concern
This review explores the emerging relationship between micro- and nanoplastic exposure and cancer risk in humans. Researchers summarized evidence suggesting that microplastics can carry carcinogenic substances and may trigger inflammatory and oxidative stress pathways linked to tumor development. The study highlights that while early evidence raises concern, more research is needed to establish clear causal connections between plastic particle exposure and specific cancer types.
Identification and analysis of microplastics in human penile cancer tissues
Researchers found microplastics in tissue samples from patients with penile cancer, with the most common types being polyethylene, polypropylene, and PVC. Cancerous tissue contained significantly more microplastics and a greater variety of plastic types than nearby healthy tissue, suggesting a possible link between microplastic accumulation and cancer development that needs further investigation.
Insights into the potential carcinogenicity of micro- and nano-plastics.
This review examined existing evidence on the carcinogenic potential of micro- and nano-plastics, finding studies demonstrating genotoxicity, oxidative DNA damage, disruption of cell signaling, and tumor-promoting effects, while noting that direct human carcinogenicity data remain limited and mechanistic pathways require further investigation.
Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer
Researchers examined tumor and surrounding tissue from colorectal cancer patients and found a diverse range of microplastics, including PVC and polyethylene, with tumor tissues containing a greater variety and higher distribution of microplastics than adjacent healthy tissue. A protein called clathrin that helps cells absorb materials was highly active in the cancer tissue, suggesting it may facilitate microplastic uptake and pointing to a potential link between microplastic exposure and colorectal cancer development.
Evaluating the relationship between microplastics and nanoplastics contamination and diverse cancer types development
This review examines growing evidence that micro- and nanoplastics found in human tissues may contribute to cancer development through several pathways. These tiny particles can generate harmful molecules called reactive oxygen species, cause chronic inflammation, and disrupt cell growth signals, all of which are known to promote cancer. While long-term, high-level exposure likely poses the greatest risk, more research is needed to understand the full cancer-related dangers of microplastic exposure.
Microplastic accumulation in endometrial cancer tissues and its metabolic impact
Researchers examined microplastic levels in endometrial cancer tissues compared to normal tissue and found that cancer tissues contained significantly higher concentrations of plastic particles. The most common plastics detected were polyethylene, polypropylene, and polystyrene. Metabolic analysis revealed that microplastic presence was associated with changes in cancer-related metabolic pathways, suggesting that microplastics may play a role in promoting tumor development through metabolic reprogramming.
Micro and nanoplastics in human carcinogenesis: Insights from in vitro studies
This narrative review compiles in vitro evidence on the carcinogenic effects of micro- and nanoplastics across multiple cancer types, examining mechanisms including oxidative stress, DNA damage, immune dysregulation, and epigenetic changes identified in cell culture experiments.
Microplastics: an often-overlooked issue in the transition from chronic inflammation to cancer
This review explores how microplastics that accumulate in the human body may trigger long-lasting inflammation, which is a known driver of cancer development. The authors describe how microplastics can disrupt the gut microbiome, activate immune responses, and alter signaling pathways in ways that could promote tumor growth over time.
Enhanced ASGR2 by microplastic exposure leads to resistance to therapy in gastric cancer
Researchers fed polystyrene microplastics to mice and found that the particles accumulated in stomach tissue, where they triggered changes associated with more aggressive cancer behavior. In gastric cancer cells, microplastic exposure increased migration, induced drug resistance to multiple cancer therapies, and activated a gene called ASGR2 that appears to drive these effects. The study suggests that microplastic accumulation in the stomach may interfere with the effectiveness of cancer treatments.