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Microplastic changes during the development of cervical cancer and its effects on the metabolomic profiles of cancer tissues
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Researchers found microplastics in cervical cancer tissue, with polyethylene and polypropylene being the most common types, and levels increased as the cancer progressed to more advanced stages. The microplastics appeared to alter the chemical environment within the cancer tissue, suggesting they may play a role in how cervical cancer develops, though more research is needed to confirm a causal link.
Recent studies have detected microplastics (MPs) in reproductive organs and found that they exert toxic effects on the reproductive system. However, the exact mechanism of action remains unclear. This study evaluates changes in MP levels in patients with cervical cancer as the disease progresses and uses untargeted metabolomics to assess the impact of MP exposure on the metabolomic profiles of cervical invasive cancer tissues. A total of 12 MP types were identified in 101 MP particles, with an average abundance of 2.24 ± 1.61 MP particles/g. Of these, polyethylene (PE, 26.73 %) and polypropylene (PP, 19.80 %) were the most frequently detected. Also, some MPs were observed to have sizes smaller than 20 µm. Notably, MP exposure levels increase as cervical cancer progresses (p < 0.05). Metabolomics analysis revealed that, among the 33 biologically significant metabolites screened, D-Mannose and cis,cis-muconic acid showed the most significant differences. Additionally, the aminosugar and nucleotide sugar metabolism pathways were the most significantly enriched in this experiment, potentially acting as pathways through which MPs may contribute to the pathogenesis of cervical cancer. The metabolites and pathways identified in this study may offer new insights and opportunities for disease research in patients with cervical cancer.
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Researchers analyzed gene activity data from cervical tissue samples to find links between microplastic chemicals and cervical cancer. Using computer modeling, they identified five genes that could help distinguish normal tissue, precancerous changes, and cancer, and found that polystyrene showed the strongest chemical interaction with one of these genes in simulated testing.
Detection and analysis of microplastics in tissues and blood of human cervical cancer patients
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In the first study of its kind, researchers detected 13 types of microplastics in the blood, tumor tissue, and surrounding tissue of cervical cancer patients using Raman spectroscopy. Microplastic levels were higher in cancerous tissue than in nearby healthy tissue, and factors like age, BMI, and bottled water consumption correlated with greater microplastic abundance, suggesting a possible link between plastic exposure and reproductive health.
Microplastic accumulation in endometrial cancer tissues and its metabolic impact
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Researchers examined microplastic levels in endometrial cancer tissues compared to normal tissue and found that cancer tissues contained significantly higher concentrations of plastic particles. The most common plastics detected were polyethylene, polypropylene, and polystyrene. Metabolic analysis revealed that microplastic presence was associated with changes in cancer-related metabolic pathways, suggesting that microplastics may play a role in promoting tumor development through metabolic reprogramming.
Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features
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Researchers detected and characterized microplastics in human gastric cancer tissue and adjacent healthy tissue, finding significantly higher microplastic concentrations in cancer tissue, and used transcriptome sequencing to explore potential molecular mechanisms linking microplastic exposure to gastric cancer development.
Detection and quantification of microplastics in various types of human tumor tissues
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Researchers detected microplastics in 43% of tumor samples across lung, gastric, colorectal, cervical, and pancreatic cancers, with polystyrene, PVC, and polyethylene being the types found. In pancreatic tumors, microplastic presence was associated with fewer immune cells that fight cancer and more immune cells linked to tumor progression, suggesting microplastics may create conditions that help tumors evade the immune system.
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