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61,005 resultsShowing papers similar to Socializing Models During Lactation Alter Colonic Mucosal Gene Expression and Fecal Microbiota of Growing Piglets
ClearIntegrated Analysis of the Transcriptome and Microbial Diversity in the Intestine of Miniature Pig Obesity Model
Researchers fed miniature pigs a high-fat, high-carbohydrate diet for 26 weeks and compared their gut health to pigs on a normal diet. The obesity-prone pigs showed increased inflammation, disrupted blood sugar metabolism, and significant declines in beneficial gut bacteria. The study reveals strong connections between diet-induced gut microbial changes and immune-related gene expression in the intestines.
Influence of selected dosages of plastic microparticles on the porcine fecal microbiome
Researchers fed pigs different doses of PET microplastics for 28 days and analyzed changes in their gut bacteria. Higher doses of microplastics increased certain bacterial groups that produce short-chain fatty acids, which are important for gut health and immune function. Since pig digestive systems are similar to humans, these results suggest microplastic exposure could alter our gut microbiome in ways that affect digestion and overall health.
Gut Microbiome and Small RNA Integrative-Omic Perspective of Meconium and Milk-FED Infant Stool Samples
Characterization of bacteriome, virome, and smallRNome in infant meconium and stool samples found that the gut environment changes rapidly after birth with the bacteriome, virome, and small RNA profiles all differing between meconium and milk-fed infant stool, suggesting transkingdom interactions shape early gut colonization.
Integration of Non-Coding RNA and mRNA Profiles Reveals the Mechanisms of Rumen Development Induced by Different Types of Diet in Calves
Researchers used integrated non-coding RNA and mRNA profiling to reveal molecular mechanisms underlying rumen development in calves fed different diet types, identifying regulatory networks that influence gastrointestinal maturation.
Associations of Plastic Bottle Exposure with Infant Fecal Microbiota, Short-Chain Fatty Acids, and Growth
Researchers investigated associations between plastic bottle use and infant gut health, examining whether exposure influences early fecal microbiota composition, short-chain fatty acid levels, and growth trajectories in infants.
Macrogenomes reveal microbial-mediated microplastic degradation pathways in the porcine gut: a hope for solving the environmental challenges of microplastics
A metagenomic study of pig gut contents found a diverse community of microorganisms harboring genes capable of breaking down multiple types of microplastics. This raises the intriguing possibility that gut microbiota in food animals may partially degrade ingested microplastics, but it also raises questions about whether breakdown products or altered microbial communities pose risks that pass up the food chain to humans.
Transcriptome Analysis Reveals the Genes Involved in Bifidobacterium Longum FGSZY16M3 Biofilm Formation
Scientists analyzed gene expression in a beneficial gut bacterium during biofilm formation, identifying key genetic networks involved. This microbiome research is relevant context for understanding how microplastics, which can disrupt gut bacterial communities, may affect the beneficial bacteria that protect digestive health.
Microplastics-gut microbiota interactions in an in vitro model of the toddler colon
Researchers used an in vitro model of the toddler colon to investigate how microplastics interact with the gut microbiota in young children. The study examined changes in microbial community composition and metabolic activity following microplastic exposure, providing early evidence of potential disruption to the developing gut ecosystem.
Infant microbiota formation: mother – placenta – fetus – baby
This review examines how infant gut microbiota forms through the mother-placenta-fetus-baby pathway, with colonization beginning during the prenatal period. The study discusses how factors such as delivery mode, breastfeeding, and maternal health shape early microbial communities that influence long-term health outcomes.
Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
This Mendelian randomization study found genetic evidence supporting a causal relationship between specific gut microbiota compositions and gastrointestinal diseases. The findings suggest that microbiome-related interventions, including microbiome-dependent metabolites, could potentially be developed to treat or manage gastrointestinal conditions.
Developmental Dynamics of the Gut Virome in Tibetan Pigs at High Altitude: A Metagenomic Perspective across Age Groups
Researchers profiled the gut virome of Tibetan pigs at high altitude using metagenomic sequencing, tracking viral community dynamics across different developmental stages. The study identified novel bacteriophages and found that gut viral diversity changed substantially with age, providing baseline data on virome development in this understudied livestock population.
The Effect of Rumen Microbiota in The Susceptibility of Subacute Ruminal Acidosis in Dairy Cows
Researchers studied how differences in rumen bacteria and fungi affect whether dairy cows develop a metabolic disease caused by high-grain diets. This gut microbiome research is not directly related to microplastics but is relevant to understanding how gut microbial communities influence susceptibility to environmental exposures.
Editorial: Impact of gut ecosystem in health and diseases: microbiome, mucosal barrier and cytokine milieu
This editorial introduces a research collection examining the gut ecosystem's role in health and disease, focusing on how the perinatal and lifetime 'exposome' (diet, pre/probiotics, environmental factors) shapes microbiome composition, mucosal barrier function, and cytokine/chemokine signaling in intestinal immunity.
In vitro modelling of oral microbial invasion in the human colon
Researchers developed an in vitro model combining the M-ARCOL colon simulator with a salivary enrichment protocol and shotgun metagenomics to study oral microbial invasion of intestinal microbiota, finding that the mucosal compartment retained the highest species richness and that oral microorganisms introduced via enriched saliva competed with established commensal communities.
Polystyrene Microplastics Disrupt Vertical Transmission of the Breast Milk Microbiome, Impairing Early‐Life Gut Colonization and Immune Development in Offspring
Researchers exposed pregnant and lactating mice to polystyrene microplastics and found that maternal exposure disrupted the breast milk microbiome, reducing beneficial bacteria like Ligilactobacillus while increasing potentially harmful ones. Offspring from exposed mothers showed altered gut colonization, excessive weight gain, reduced immune markers, and compromised intestinal barrier integrity, suggesting microplastics may affect infant development through changes in breast milk composition.
Combined Omics Analysis Further Unveils the Specific Role of Butyrate in Promoting Growth in Early-Weaning Animals
Researchers investigated whether dietary butyrate supplementation could improve intestinal health and growth in early-weaned rabbits using combined transcriptomic and metabolomic analysis. They found that butyrate strengthened the intestinal barrier, improved gut microbial balance by suppressing harmful bacteria, and enhanced metabolic pathways related to inflammation reduction and antioxidant capacity. The study suggests that butyrate supplementation may help alleviate the intestinal disruption commonly caused by early weaning in young animals.
The effects of food provisioning on the gut microbiota community and antibiotic resistance genes of Yunnan snub-nosed monkey
Researchers compared the gut bacteria and antibiotic resistance genes of Yunnan snub-nosed monkeys that receive supplemental food from a reserve with those of wild-foraging groups. The study found differences in microbial communities between the two groups, suggesting that food provisioning programs, while helpful for population recovery, may alter the gut health of these endangered primates.
Environmental Microplastic Exposure Changes Gut Microbiota in Chickens
Researchers exposed chickens to environmentally relevant concentrations of microplastics and found that their growth performance decreased significantly. The gut microbiota composition was also altered, with changes in the abundance of several bacterial groups important for digestion and health. The study suggests that microplastic contamination in poultry environments could affect both animal welfare and the broader food production chain.
Exploring the Crucial Role of the Gut Microbiome in Advancing Food Processing Technologies
This review explores the role of gut microbiome composition in food processing and technology development, examining how microbial communities influence fermentation, nutrient bioavailability, and food safety, with implications for probiotic and prebiotic product design.
Omics analysis of the effect of cold normal saline stress through gastric gavage on LPS induced mice
Not relevant to microplastics — this study uses microbiome sequencing to investigate how cold stress combined with bacterial lipopolysaccharide affects the intestinal microbiota of mice.
Effects induced by polyethylene microplastics oral exposure on colon mucin release, inflammation, gut microflora composition and metabolism in mice
Researchers fed mice polyethylene microplastics for 30 days and found that even low doses reduced protective mucus in the colon, altered inflammation markers, and shifted the composition of gut bacteria. The microplastics increased the ratio of Bacteroides to Firmicutes bacteria and affected metabolic pathways in the gut microbiome. The study suggests that oral microplastic exposure may disrupt intestinal health by modifying the gut microbial community and its metabolism.
Within-species variation in the gut microbiome of medaka ( Oryzias latipes ) is driven by the interaction of light intensity and genetic background
This study found that gut microbiome composition in medaka fish is shaped by the interaction between genetic background and light intensity, with fishing-like selective pressure reducing bacterial richness under low-light conditions, though this did not affect growth rates.
Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice
Researchers used multi-omics analysis to reveal that liver injury in colitis mice is linked to intestinal dysbiosis and altered host-microbiota interactions, with gut bacterial shifts correlating to immune and metabolic changes in the liver.
Methylation patterns and mathematical models reveal dynamics of stem cell turnover in the human colon
Researchers investigated the dynamics of stem cell turnover in the human colon using methylation patterns as biomarkers, finding that mathematical modeling of these epigenetic marks can reveal the rates at which colonic stem cells divide and are replaced over time.