We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Combined Omics Analysis Further Unveils the Specific Role of Butyrate in Promoting Growth in Early-Weaning Animals
Summary
Researchers investigated whether dietary butyrate supplementation could improve intestinal health and growth in early-weaned rabbits using combined transcriptomic and metabolomic analysis. They found that butyrate strengthened the intestinal barrier, improved gut microbial balance by suppressing harmful bacteria, and enhanced metabolic pathways related to inflammation reduction and antioxidant capacity. The study suggests that butyrate supplementation may help alleviate the intestinal disruption commonly caused by early weaning in young animals.
Abnormal mutations in the microbial structure of early-weaning mammals are an important cause of enteritis. Based on the multiple known beneficial functions of butyrate, we hypothesized that butyrate would alleviate the imbalance of intestinal homeostasis induced by early weaning in animals. However, the mechanisms of action between butyrate and intestinal microbes are still poorly explored. In this study, we aimed to investigate whether butyrate exerts beneficial effects on the structure of the intestinal flora of weanling rabbits and their intestinal homeostasis, growth and development, and we attempted to elucidate the potential mechanisms of action through a combined omics analysis. We found that dietary butyrate upregulated the transcription of tight junction-related proteins in the epithelial barrier and improved the intestinal microbial structure by suppressing harmful bacteria and promoting beneficial ones. Intestinal and plasma metabolomes were also altered. The bile acid secretion, α-linolenic acid, apoptotic, and prostate cancer pathways responded to the positive dietary butyrate-induced metabolic changes in the weanling rabbits, resulting in the inhibition of inflammation, improved antioxidant capacity, increased rates of cell proliferation and survival, and decreased levels of apoptosis. Additionally, dietary butyrate suppressed the release of pro-inflammatory factors and enhanced positive appetite regulation, which increased the average daily gain of the rabbits. These results demonstrated that dietary butyrate can help maintain the integrity of the intestinal epithelial barrier, improve the structural composition of the intestinal microflora, enhance organismal metabolism, inhibit inflammation, reduce post-weaning anorexia, and promote growth and development in early-weaning rabbits. These positive effects of dietary butyrate were exerted via the modulation of the microbe-gut-brain axis.
Sign in to start a discussion.
More Papers Like This
Integration of Non-Coding RNA and mRNA Profiles Reveals the Mechanisms of Rumen Development Induced by Different Types of Diet in Calves
Researchers used integrated non-coding RNA and mRNA profiling to reveal molecular mechanisms underlying rumen development in calves fed different diet types, identifying regulatory networks that influence gastrointestinal maturation.
Carvacrol attenuated lipopolysaccharide-induced intestinal injury by down-regulating TLRs gene expression and regulating the gut microbiota in rabbit
Researchers tested whether carvacrol, a natural plant compound found in oregano and thyme, could protect the intestines of rabbits challenged with a bacterial toxin (lipopolysaccharide), finding it reduced inflammation, improved gut lining structure, and restored healthier gut bacteria communities. These results suggest carvacrol could be a useful dietary supplement for protecting intestinal health in rabbit farming.
Sodium acetate/sodium butyrate alleviates lipopolysaccharide-induced diarrhea in mice via regulating the gut microbiota, inflammatory cytokines, antioxidant levels, and NLRP3/Caspase-1 signaling
Researchers found that sodium acetate and sodium butyrate supplementation alleviated lipopolysaccharide-induced diarrhea in mice by restoring gut microbiota balance, reducing inflammatory cytokines, enhancing antioxidant levels, and inhibiting the NLRP3/Caspase-1 signaling pathway.
Exposure to polyethylene microplastics alters immature gut microbiome in an infant in vitro gut model
Researchers used an artificial infant gut model to study how chronic exposure to polyethylene microplastics affects the developing intestinal microbiome. They found that microplastics shifted gut microbial composition, increasing the abundance of potentially harmful bacteria such as Enterobacteriaceae while decreasing beneficial butyrate production. The study suggests that microplastic ingestion may disrupt the gut microbiome of infants, though no significant damage to the intestinal barrier was observed.
Reduced Glutathione Promoted Growth Performance by Improving the Jejunal Barrier, Antioxidant Function, and Altering Proteomics of Weaned Piglets
A study of 180 weaned piglets showed that adding reduced glutathione to their diet improved growth, strengthened the intestinal barrier, and boosted antioxidant defenses in the gut. These findings suggest that glutathione supplementation could serve as a potential alternative to antibiotics for supporting young animal health during the stressful weaning period.