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20 resultsShowing papers similar to Quercetin Prevents Bisphenol S Induced Behavioral Changes and Oxidative Stress iZebrafish by Modulating Brain Antioxidant Defense Mechanism
ClearEvaluation of protective efficacy of quercetin on microplastic induced behavioural toxicity in zebrafish (Danio rerio)
Zebrafish were exposed to microplastics alone and in combination with quercetin at 75 ug/L for 21 days to evaluate whether quercetin could protect against microplastic-induced behavioral toxicity. Microplastic exposure caused behavioral abnormalities, and quercetin treatment modified these effects in a dose-dependent manner, suggesting antioxidant supplementation as a potential protective strategy.
Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment
This review examines how nano- and micro-sized plastic particles cause toxic effects in zebrafish, focusing on the link between oxidative stress and neurodevelopmental damage. Researchers found that plastic particle exposure disrupts the balance of reactive oxygen species in cells, which can impair brain development and nervous system function. The study suggests these oxidative stress responses may serve as early warning signals of plastic particle toxicity in aquatic organisms.
Vitamin E Mitigates Polystyrene-Nanoplastic-Induced Visual Dysfunction in Zebrafish Larvae
Researchers found that vitamin E, a common antioxidant, can protect against vision damage caused by polystyrene nanoplastics in zebrafish larvae. The nanoplastics caused eye defects and visual impairment by triggering harmful oxidative stress, but vitamin E treatment significantly reduced this damage, suggesting antioxidants might help counteract some harmful effects of nanoplastic exposure.
Do Microplastics Have Neurological Implications in Relation to Schizophrenia Zebrafish Models? A Brain Immunohistochemistry, Neurotoxicity Assessment, and Oxidative Stress Analysis
Zebrafish exposed to microplastics showed increased brain damage and oxidative stress, especially when combined with chemicals that mimic schizophrenia-related conditions. The study suggests microplastics may worsen neurological problems by interacting with other brain-altering substances, highlighting potential concerns about how plastic pollution could contribute to neuropsychiatric disorders.
Correction by "Quertin" of the oxidative-antioxidant system of rats at xenobiotics exposure
This study tested whether the antioxidant flavonoid quercetin could protect rats from oxidative damage caused by xenobiotic (foreign chemical) exposure, finding that quercetin administration reduced biomarkers of oxidative stress and liver damage. The results suggest that natural antioxidants may help counteract some biochemical effects of environmental chemical exposures.
Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio)
Researchers developed a biosurfactant-microplastic hybrid and tested whether coating microplastics with biosurfactant could reduce their toxicity in zebrafish. They found that the biosurfactant coating reduced oxidative stress and cell death caused by the microplastics, lowering their overall biological harm. The study suggests that biosurfactants could potentially serve as a mitigation strategy for reducing microplastic toxicity in aquatic environments.
Quercetin intervention mitigates small intestinal damage and immunologic derangement induced by polystyrene nanoplastics: Insights from multi-omics analysis in mice
Researchers found that quercetin, a natural compound found in fruits and vegetables, protected mice from gut damage and immune system disruption caused by polystyrene nanoplastics. The nanoplastics damaged the small intestine and disrupted immune balance, but quercetin reversed much of this harm by restoring healthy gut bacteria and gene activity. This suggests that dietary compounds like quercetin might help counteract some negative health effects of nanoplastic exposure.
Malathion-induced Biochemical and Molecular Changes in the Brain of Danio rerio as Biomarkers of Oxidative Stress Damage
Not relevant to microplastics — this study examines how the pesticide malathion causes oxidative stress and neurological damage in zebrafish brains, using antioxidant enzyme activity and gene expression as biomarkers.
A current perspective on the relevance of nano and microplastics in the neurodevelopmental disorders: further relevance for metabolic, gastrointestinal, oxidative stress-related and zebrafish studies
This review examines evidence that micro- and nanoplastics may affect brain development and neurological function, drawing on studies in zebrafish and other animal models. The authors discuss potential mechanisms including oxidative stress and endocrine disruption, and call for more research on the neurodevelopmental risks of plastic particle exposure.
Evaluation of antioxidant response and Na+-K+-ATPase activity in zebrafish exposed to polyethylene microplastics: Shedding light on a physiological adaptation
Researchers evaluated the antioxidant response and ion transport enzyme activity in zebrafish exposed to environmentally relevant concentrations of polyethylene microplastics, finding evidence of physiological adaptation mechanisms in response to microplastic exposure.
Natural-based solutions to mitigate dietary microplastics side effects in fish
Zebrafish reared for 6 months on diets containing microencapsulated astaxanthin and microplastics showed reduced oxidative stress and lower MP accumulation in liver compared to controls, suggesting antioxidant supplementation can mitigate the toxicological effects of dietary microplastic exposure.
Microplastics enhance the developmental toxicity of synthetic phenolic antioxidants by disturbing the thyroid function and metabolism in developing zebrafish
Researchers studied how polystyrene microplastics affect the toxicity of BHA, a synthetic antioxidant commonly used in plastics, on developing zebrafish. The study found that co-exposure to microplastics and BHA enhanced developmental toxicity by disrupting thyroid function and metabolism, suggesting that microplastics can amplify the harmful effects of their own chemical additives on aquatic organisms.
Neurological effects induced by micro- and nanoplastics in fish: a systematic review and meta-analysis
This meta-analysis pooled data from 59 controlled studies and found that micro- and nanoplastics cause significant neurological effects in fish, including reduced brain antioxidant defenses and altered behavior. These findings are concerning because they suggest plastic pollution may disrupt nervous system function across species, and contaminated fish is a major part of the human diet.
Toxic effects of naturally-aged microplastics on zebrafish juveniles: A more realistic approach to plastic pollution in freshwater ecosystems
Researchers exposed juvenile zebrafish to naturally aged polystyrene microplastics at environmentally relevant concentrations for five days. They found that the microplastics disrupted the fish's antioxidant defenses, indicating oxidative stress, and caused measurable cellular and neurological impacts. The study suggests that even short-term exposure to realistic levels of weathered microplastics can affect the health of freshwater organisms.
Neurotoxicity of Plastics: Mechanistic Insights into the Progression of Neurodegenerative Diseases in Animal Models
This review summarizes evidence from rodent and zebrafish studies showing that plastic-derived chemicals — including BPA, phthalates, and micro/nanoplastics — penetrate or impair the blood-brain barrier and trigger oxidative stress, neuroinflammation, and neurodegeneration.
Attenuative effects of tamarixetin against polystyrene microplastics‐induced hepatotoxicity in rats by regulation of Nrf‐2/Keap‐1 pathway
Researchers investigated whether tamarixetin, a naturally occurring flavonoid, could reduce liver damage caused by polystyrene microplastic exposure in rats. The study found that tamarixetin helped protect against microplastic-induced liver toxicity by activating antioxidant defense pathways, suggesting potential protective effects of certain plant-derived compounds against microplastic-related oxidative stress.
A review on the impacts of nanomaterials on neuromodulation and neurological dysfunction using a zebrafish animal model
This review assessed zebrafish as a model for studying nanomaterial neurotoxicity, summarizing evidence that various engineered nanoparticles including those associated with plastics can impair zebrafish neural development, behavior, and neurotransmitter systems. The authors highlighted zebrafish as particularly useful for rapid in vivo screening of nanomaterial neurological effects.
Superoxide Dismutase 3 Deficiency Disrupts the Regulation of Oxidative Stress Caused by Polystyrene Nanoplastics
Researchers used superoxide dismutase 3 (SOD3) knockout zebrafish to investigate the role of extracellular antioxidant defenses in polystyrene nanoplastic toxicity, finding that SOD3 deficiency worsened nanoplastic-induced oxidative stress, demonstrating that extracellular antioxidant capacity is an important determinant of nanoplastic harm.
Lycopene againsts the polystyrene microplastics-induced neurotoxicity via modulation of mTOR/Beclin-1 activities in adult male Wistar rats
Researchers found that lycopene, a natural compound found in tomatoes, protected rat brains from damage caused by polystyrene microplastics. The microplastics caused oxidative stress, disrupted neurotransmitter balance, and triggered harmful cellular processes in the brain, but lycopene treatment reversed many of these effects. This study suggests that antioxidant-rich foods might help protect against the brain-damaging effects of microplastic exposure.
Effects of Microplastics and Nanoplastics on Neurodevelopment and Neurodegeneration in Zebrafish
This review covers how micro- and nanoplastic (MNP) exposure affects neurodevelopment and neurodegeneration in zebrafish, summarising evidence on impaired neurodevelopment, behavioural changes, and markers of neurodegeneration from studies using various polymer types and exposure routes. It frames zebrafish as a key model for understanding MNP neurotoxicity.