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Vitamin E Mitigates Polystyrene-Nanoplastic-Induced Visual Dysfunction in Zebrafish Larvae
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Researchers found that vitamin E, a common antioxidant, can protect against vision damage caused by polystyrene nanoplastics in zebrafish larvae. The nanoplastics caused eye defects and visual impairment by triggering harmful oxidative stress, but vitamin E treatment significantly reduced this damage, suggesting antioxidants might help counteract some harmful effects of nanoplastic exposure.
Vitamin E (VitE), a potent antioxidant, has demonstrated significant potential in mitigating oxidative stress and cellular damage, making it a valuable agent for countering environmental toxicities, including those caused by polystyrene nanoplastics (PSNPs). This study examined the effects of PSNPs on the zebrafish visual system and evaluated the protective role of VitE. Zebrafish embryos were exposed to PSNPs (0.01, 0.1, 1, and 10 μg/mL) with or without 20 μM VitE co-treatment from fertilization to 6 days post-fertilization (dpf). Visual function, morphology, and molecular responses were assessed at 4 or 6 dpf. Exposure to PSNPs at concentrations of 0.1 to 10 μg/mL significantly increased bioaccumulation in the zebrafish eye in a concentration-dependent manner and disrupted the visual system. These disruptions caused a reduction in the eye-to-body length ratio and decreased optomotor response positivity and swimming distance, indicating impaired visual function and behavior. Furthermore, PSNPs elevated reactive oxygen species (ROS) levels, induced retinal apoptosis, and disrupted gene expression related to visual development (six6, pax2, pax6a, and pax6b), apoptosis (tp53, casp3, bax, and bcl2a), and antioxidant defense (sod1, cat, and gpx1a). VitE co-treatment significantly mitigated these adverse effects, reducing oxidative damage, restoring antioxidant defenses, and preserving retinal function. This study highlights the potential of VitE as a protective agent against PSNP-induced visual dysfunction and underlines the urgent need to address nanoplastic pollution to protect aquatic ecosystems.
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Polystyrene nanoplastics cause developmental abnormalities, oxidative damage and immune toxicity in early zebrafish development
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Zebrafish embryos exposed to polystyrene nanoplastics showed dose-dependent developmental problems including delayed hatching, reduced survival, smaller body size, and the nanoplastics accumulated in critical organs like the eyes, heart, liver, and brain. The particles triggered oxidative stress that damaged cells and activated inflammatory immune responses, demonstrating how nanoplastic contamination in water can cause widespread harm to developing organisms.
Developmental cardiovascular disruption triggered by polystyrene nanoplastics in zebrafish mediated through oxidative stress
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Researchers exposed zebrafish embryos to polystyrene nanoplastics and observed disrupted heart development, including abnormal heart rate, swelling around the heart, and impaired blood vessel formation. The damage was linked to oxidative stress, and treatment with the antioxidant glutathione significantly reduced the harmful effects. The findings suggest that nanoplastic pollution in waterways may pose risks to cardiovascular development and that antioxidant-based strategies could help counteract the damage.
Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (Danio rerio)
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Researchers exposed zebrafish embryos to polystyrene nanoplastics at various concentrations and found significant developmental abnormalities including reduced hatching rates and increased malformations. The nanoplastics activated oxidative stress responses and DNA repair pathways, indicating cellular damage during critical early development stages. The study provides mechanistic evidence for how nanoplastic exposure can disrupt normal embryonic development in aquatic organisms.
Polystyrene Nanoparticles in Zebrafish: Their Role in Ocular Stress and Lipid Metabolic Imbalance
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Polystyrene nanoparticles were detected in zebrafish eyes at 96 hours post-fertilization using Raman microscopy, and exposure induced protein structural changes and lipid metabolic imbalance specifically in ocular tissue, suggesting the eye is a vulnerable target for nanoplastic accumulation.
Polystyrene nanoplastics chronic exposure cause zebrafish visual neurobehavior toxicity through TGFβ-crystallin axis
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Zebrafish chronically exposed to polystyrene nanoplastics showed significant vision problems, including structural damage to the retina and lens, with the largest particles (500 nm) causing the worst effects. The nanoplastics accumulated in retinal tissue and disrupted key signaling pathways involved in vision, suggesting that long-term nanoplastic exposure could pose risks to eye health.
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