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20 resultsShowing papers similar to Prevention of Loperamide-Induced Constipation in Mice and Alteration of 5-Hydroxytryotamine Signaling by Ligilactobacillus salivarius Li01
ClearLactobacillus plantarum A3 attenuates ulcerative colitis by modulating gut microbiota and metabolism
Researchers showed that Lactobacillus plantarum A3, a probiotic strain isolated from horses, reduced symptoms of ulcerative colitis in mice whose gut microbiomes had been disrupted by antibiotics. The probiotic restored beneficial bacteria like Akkermansia, reduced gut inflammation, and increased levels of natural anti-inflammatory compounds in the body.
Sodium Humate Alleviates Enterotoxigenic Escherichia coli-Induced Intestinal Dysfunction via Alteration of Intestinal Microbiota and Metabolites in Mice
Researchers found that sodium humate supplementation alleviated intestinal damage caused by enterotoxigenic Escherichia coli infection in mice by improving gut microbiota composition, modulating metabolites, and reducing intestinal inflammation and barrier dysfunction.
Effects of mixed lactic acid bacteria on intestinal microbiota of mice infected with Staphylococcus aureus
Researchers found that infection with Staphylococcus aureus, a common harmful bacterium, disrupts the normal balance of gut microbiota in mice, but that treatment with a mix of beneficial lactic acid bacteria (LAB) — similar to probiotics — helped prevent the infection and restore a healthier gut microbial community. This highlights the potential of probiotic bacteria to protect gut health against pathogenic disruption.
Sodium acetate/sodium butyrate alleviates lipopolysaccharide-induced diarrhea in mice via regulating the gut microbiota, inflammatory cytokines, antioxidant levels, and NLRP3/Caspase-1 signaling
Researchers found that sodium acetate and sodium butyrate supplementation alleviated lipopolysaccharide-induced diarrhea in mice by restoring gut microbiota balance, reducing inflammatory cytokines, enhancing antioxidant levels, and inhibiting the NLRP3/Caspase-1 signaling pathway.
Improvement of the intestinal epithelial barrier during laxative effects of phlorotannin in loperamide-induced constipation of SD rats
Researchers found that phlorotannin, a natural compound found in brown seaweed, relieves constipation in rats by repairing the intestinal epithelial barrier — the protective lining of the gut — suggesting it may support healthy gut function.
Mechanism of Mulberry Leaves and Black Sesame in Alleviating Slow Transit Constipation Revealed by Multi-Omics Analysis
Researchers examined how mulberry leaves and black sesame alleviate slow transit constipation in a mouse model, measuring gut motility, microbiota composition, and intestinal gene expression. Both dietary interventions increased beneficial bacteria, enhanced gut peristalsis, and upregulated genes associated with intestinal motility, supporting their traditional use for digestive health.
Black Lycium barbarum polysaccharide attenuates LPS-induced intestine damage via regulation gut microbiota
Researchers studied whether a polysaccharide from black Lycium barbarum could protect against intestinal damage caused by bacterial toxins in mice. They found that the supplement alleviated intestinal tissue damage and improved gut microbiota diversity by promoting beneficial bacteria. The study suggests that this plant-derived polysaccharide may help maintain intestinal health by modulating the gut microbial community.
Deciphering Microbiome, Transcriptome, and Metabolic Interactions in the Presence of Probiotic Lactobacillus acidophilus against Salmonella Typhimurium in a Murine Model
Researchers tested whether the probiotic Lactobacillus acidophilus could protect mice against Salmonella Typhimurium infection by examining changes in gut bacteria, gene expression, and metabolic pathways. They found that probiotic treatment improved gut microbial balance, reduced harmful bacterial load, and modulated immune and metabolic responses. The study suggests that probiotics may offer a promising alternative strategy to antibiotics for managing certain foodborne bacterial infections.
A probiotic for preventing microplastic toxicity: Clostridium dalinum mitigates microplastic-induced damage via microbiota-metabolism-barrier interactions
Using metagenomics and metabolomics, this study found that the probiotic bacterium Clostridium dalinum reduced microplastic-induced gut damage in mice by modulating gut microbiota composition, metabolic pathways, and intestinal barrier integrity.
Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis
The probiotic strain Lactiplantibacillus plantarum ZP-6 mitigated polystyrene nanoplastic-induced liver injury in an animal model through multiple mechanisms including toxin binding, barrier enhancement, and anti-inflammatory activity, suggesting probiotics as a potential strategy for reducing nanoplastic health impacts.
A Single Strain of Lactobacillus (CGMCC 21661) Exhibits Stable Glucose- and Lipid-Lowering Effects by Regulating Gut Microbiota
Researchers identified a novel Lactobacillus strain (CGMCC 21661) that outperformed fecal microbiota transplantation and Bifidobacterium in lowering blood glucose and lipids in diabetic mice, demonstrating stable therapeutic effects through gut microbiota regulation.
Lactobacillus plantarum reduces polystyrene microplastic induced toxicity via multiple pathways: A potentially effective and safe dietary strategy to counteract microplastic harm
Researchers found that Lactobacillus plantarum, a probiotic bacterium commonly found in fermented foods, can reduce the harmful effects of polystyrene microplastics in mice through multiple pathways. The bacteria worked by binding directly to plastic particles to help remove them from the body, reducing oxidative damage, repairing the intestinal barrier, and regulating bile acid metabolism. This suggests that certain probiotics could be a safe dietary strategy to help counteract some of the negative health effects of microplastic exposure.
Lactiplantibacillus plantarum P101 Alleviates Liver Toxicity of Combined Microplastics and Di-(2-Ethylhexyl) Phthalate via Regulating Gut Microbiota
Researchers found that the probiotic Lactiplantibacillus plantarum P101 reduced liver damage caused by combined exposure to microplastics and the plasticizer DEHP in mice. The probiotic reversed oxidative stress and inflammation in the liver and intestines while reshaping the gut microbiota. The study suggests that probiotic supplementation may offer a promising strategy for mitigating the toxic effects of co-exposure to microplastics and plastic-associated chemicals.
Dexmedetomidine alleviates intestinal barrier dysfunction and inflammatory response in mice via suppressing TLR4/MyD88/NF-κB signaling in an experimental model of ulcerative colitis
Researchers investigated whether dexmedetomidine (DEX), a sedative agent, alleviates intestinal barrier dysfunction and inflammatory responses in a mouse model of ulcerative colitis, finding that DEX suppresses the TLR4/MyD88/NF-kB signaling pathway to reduce epithelial cell apoptosis and inflammation. The results suggest that DEX may have therapeutic potential for protecting intestinal barrier integrity in inflammatory bowel conditions.
Effects of repeated intragastric administrations with heat-inactivated Mycobacterium aurum DSM 33539 on the stress-induced aggravation of dextran sulfate sodium (DSS) colitis in C57BL/6N mice
Researchers tested whether a heat-inactivated preparation of the soil bacterium Mycobacterium aurum could protect mice from stress-aggravated intestinal inflammation. They found that oral administration of M. aurum reduced the severity of stress-induced colitis and helped maintain intestinal barrier integrity. The study suggests that certain beneficial environmental bacteria may help protect gut health under stressful conditions, though more research is needed.
Microplastics alter gut serotonin levels in the absence of overt intestinal inflammation 4808
Researchers fed mice various sizes of polystyrene microplastics for 12 weeks and found that MPs altered gut serotonin levels and changed mucosal immune responses without causing overt intestinal inflammation, suggesting subtle disruption of gut signaling pathways.
Protective Effect and Mechanism of Aspirin Eugenol Ester on Lipopolysaccharide-Induced Intestinal Barrier Injury
Researchers investigated whether aspirin eugenol ester (AEE) could protect against intestinal inflammation and barrier damage caused by bacterial endotoxin in cell and rat models. They found that AEE significantly reduced pro-inflammatory cytokines, oxidative stress, and intestinal tissue damage while preserving the expression of key barrier proteins. The study also showed that AEE improved gut microbiota composition, suggesting it may help maintain intestinal health under inflammatory conditions.
The probiotic SLAB51 as agent to counteract BPA toxicity on zebrafish gut microbiota -liver-brain axis
Researchers tested whether the probiotic supplement SLAB51 could counteract the harmful effects of bisphenol A (BPA), a plastic-derived chemical, in zebrafish and found it significantly restored healthy gut bacteria, reduced liver damage, and protected the brain — suggesting probiotics may help offset harm from plastic-associated chemical exposure.
Gastrointestinal problems in a valproic acid-induced rat model of autism: From maternal intestinal health to offspring intestinal function
Researchers studied gastrointestinal problems in a rat model of autism and found connections between maternal gut inflammation, disrupted gut bacteria, and digestive issues in offspring. The study suggests that intestinal health problems seen in autism spectrum conditions may have roots in the maternal environment during development. Further research is needed to better understand how maternal gut health influences digestive function in neurodevelopmental conditions.
Gut microbiota and liver metabolomics reveal the potential mechanism of Lactobacillus rhamnosus GG modulating the liver toxicity caused by polystyrene microplastics in mice
Researchers found that the probiotic Lactobacillus rhamnosus GG helped protect mice from liver damage caused by polystyrene microplastic exposure. The probiotic worked by restoring healthy gut bacteria and normalizing liver metabolic pathways disrupted by the microplastics. The study suggests that supporting gut health through beneficial bacteria may help mitigate some of the toxic effects microplastics have on the liver.