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Lactiplantibacillus plantarum P101 Alleviates Liver Toxicity of Combined Microplastics and Di-(2-Ethylhexyl) Phthalate via Regulating Gut Microbiota
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Researchers found that the probiotic Lactiplantibacillus plantarum P101 reduced liver damage caused by combined exposure to microplastics and the plasticizer DEHP in mice. The probiotic reversed oxidative stress and inflammation in the liver and intestines while reshaping the gut microbiota. The study suggests that probiotic supplementation may offer a promising strategy for mitigating the toxic effects of co-exposure to microplastics and plastic-associated chemicals.
Microplastics (MPs) and Di-(2-ethylhexyl) phthalate (DEHP) as emerging contaminants, have caused increasing concern due to their co-exposure risks and toxicities to humans. Lactic acid bacteria have been demonstrated to play a significant role in the mitigation of organismal damage. Probiotic intervention is widely recognized as a safe and healthy therapeutic strategy for targeting the mitigation of organic damage. This study explored the effectiveness and underlining mechanism of an excellent probiotic property Lactiplantibacillus plantarum P101 (L. plantarum P101) to the combined hepatotoxicity of MPs and DEHP. In this study, mice were exposed to DEHP and MPs via free drinking water, followed by intervention with L. plantarum P101. Results showed that co-exposure to DEHP and MPs caused severe oxidative stress and inflammation in the liver and intestines, which was reversed after probiotic intervention. Moreover, the intervention reshaped the structure of gut microbiota and alleviated the liver damage after the combined exposure. Together, we found the intervention of L. plantarum P101 effectively mitigated the toxic effects on the liver system caused by the co-exposure to MPs and DEHP, offering a promising strategy for reducing the combined toxicity of these substances.
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Researchers found that the probiotic Lactobacillus rhamnosus GG helped protect mice from liver damage caused by polystyrene microplastic exposure. The probiotic worked by restoring healthy gut bacteria and normalizing liver metabolic pathways disrupted by the microplastics. The study suggests that supporting gut health through beneficial bacteria may help mitigate some of the toxic effects microplastics have on the liver.
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The probiotic strain Lactiplantibacillus plantarum ZP-6 mitigated polystyrene nanoplastic-induced liver injury in an animal model through multiple mechanisms including toxin binding, barrier enhancement, and anti-inflammatory activity, suggesting probiotics as a potential strategy for reducing nanoplastic health impacts.
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In 138 people, the amount of microplastic found in stool varied with the abundance of the gut bacterium Lactiplantibacillus plantarum. Researchers isolated strain PD01 and gave it to mice on a mixed microplastic diet. Treated mice had 50 to 91% less of four plastics remaining in the intestinal tract, depending on the polymer.
Combined Enterohepatic Toxicity of Polystyrene Microplastics and Di(2-ethylhexyl) Phthalate in Mice: Gut Microbiota-Dependent Synergistic Effects
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Researchers investigated the combined toxicity of polystyrene microplastics and the plasticizer DEHP in mice, focusing on gut-liver axis effects. They found that co-exposure worsened harmful outcomes compared to either pollutant alone, with gut microbiota playing a key mediating role in the synergistic toxicity. The study suggests that microplastics and their associated chemical additives may interact to amplify health risks through disruption of the gut-liver connection.
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