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Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis

Frontiers in Microbiology 2025
Lili Zhao, Zihan Wei, Yibin Wang, Wanrong Chen, Wenjing Zhang, Mengfei Xie, Hong Chen, Yiping Zhang, Haiyan Gao, Xiaobing Jiang

Summary

The probiotic strain Lactiplantibacillus plantarum ZP-6 mitigated polystyrene nanoplastic-induced liver injury in an animal model through multiple mechanisms including toxin binding, barrier enhancement, and anti-inflammatory activity, suggesting probiotics as a potential strategy for reducing nanoplastic health impacts.

Polymers
Models

These results elucidate a multifaceted probiotic mechanism for NPs detoxification, providing a promising translational strategy to counteract nanoplastic-related health hazards.

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