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Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis
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The probiotic strain Lactiplantibacillus plantarum ZP-6 mitigated polystyrene nanoplastic-induced liver injury in an animal model through multiple mechanisms including toxin binding, barrier enhancement, and anti-inflammatory activity, suggesting probiotics as a potential strategy for reducing nanoplastic health impacts.
These results elucidate a multifaceted probiotic mechanism for NPs detoxification, providing a promising translational strategy to counteract nanoplastic-related health hazards.
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Gut microbiota and liver metabolomics reveal the potential mechanism of Lactobacillus rhamnosus GG modulating the liver toxicity caused by polystyrene microplastics in mice
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Researchers found that the probiotic Lactobacillus rhamnosus GG helped protect mice from liver damage caused by polystyrene microplastic exposure. The probiotic worked by restoring healthy gut bacteria and normalizing liver metabolic pathways disrupted by the microplastics. The study suggests that supporting gut health through beneficial bacteria may help mitigate some of the toxic effects microplastics have on the liver.
Lactiplantibacillus plantarum P101 Alleviates Liver Toxicity of Combined Microplastics and Di-(2-Ethylhexyl) Phthalate via Regulating Gut Microbiota
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Researchers found that the probiotic Lactiplantibacillus plantarum P101 reduced liver damage caused by combined exposure to microplastics and the plasticizer DEHP in mice. The probiotic reversed oxidative stress and inflammation in the liver and intestines while reshaping the gut microbiota. The study suggests that probiotic supplementation may offer a promising strategy for mitigating the toxic effects of co-exposure to microplastics and plastic-associated chemicals.
A probiotic for preventing microplastic toxicity: Clostridium dalinum mitigates microplastic-induced damage via microbiota-metabolism-barrier interactions
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Using metagenomics and metabolomics, this study found that the probiotic bacterium Clostridium dalinum reduced microplastic-induced gut damage in mice by modulating gut microbiota composition, metabolic pathways, and intestinal barrier integrity.
Polystyrene nanoplastics sequester the toxicity mitigating potential of probiotics by altering gut microbiota in grass carp (Ctenopharyngodon idella)
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Researchers tested whether probiotic pretreatment could protect grass carp from the toxic effects of polystyrene nanoplastics on gut health. While probiotics initially boosted immune responses and reduced intestinal damage, the protective effect was not strong enough to fully counteract nanoplastic toxicity over time. The study suggests that nanoplastics can undermine the gut health benefits of probiotics by disrupting the balance of gut bacteria.
Gut dysbiosis exacerbates inflammatory liver injury induced by environmentally relevant concentrations of nanoplastics via the gut-liver axis
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This mouse study found that swallowing nanoplastics at levels found in the environment disrupted gut bacteria and damaged the intestinal barrier, allowing toxins to leak into the bloodstream and cause liver inflammation. When researchers transplanted gut bacteria from nanoplastic-exposed mice into healthy mice, those mice also developed liver damage. This demonstrates that nanoplastics may harm the liver indirectly by first disrupting the gut, a finding relevant to understanding how everyday plastic exposure could affect human health.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.