We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to The potential mechanism of huazhuojiedu decoction in the treatment of ulcerative colitis based on network pharmacology and experimental validation
ClearMechanisms underlying the therapeutic effects of Semen cuscutae in treating recurrent spontaneous abortion based on network pharmacology and molecular docking
Researchers used network pharmacology and molecular docking to investigate how compounds from the traditional Chinese medicine Semen cuscutae may interact with inflammatory targets related to recurrent spontaneous abortion. The study identified sesamin as a key compound that showed strong binding affinity to relevant molecular targets, providing a theoretical basis for further investigation of this traditional remedy.
Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of Bushen Huashi decoction against kidney stones
This study used network pharmacology and laboratory validation to reveal that a traditional Chinese herbal formula (Bushen Huashi decoction) combats kidney stones by modulating estrogen receptor, NRF2/HO-1 antioxidant, and apoptosis signaling pathways.
Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of salidroside on intestine ischemia reperfusion
Researchers investigated the therapeutic mechanism of salidroside for intestinal ischemia-reperfusion injury using network pharmacology and experimental validation, finding that it may target AMPK and TXNIP domains to provide protective effects.
Jianwei Xiaoshi oral liquid attenuates high-calorie diet-induced dyspepsia in immature rats via regulating the pancreatic secretion pathway and maintaining the homeostasis of intestinal microbiota
Researchers found that a traditional Chinese herbal medicine formula called Jianwei Xiaoshi oral liquid improved functional digestive problems in young rats fed a high-calorie diet by regulating eight key proteins involved in pancreatic digestion and restoring healthy gut bacteria balance. The findings suggest potential therapeutic benefits of this herbal remedy for diet-induced digestive disorders in children.
The Potential Role and Effective Components of Sanyeqing as the Potential Therapeutic Candidates for IBD and CRC
This review examines the phytochemical constituents of Sanyeqing (a traditional medicinal plant) and their therapeutic potential for inflammatory bowel disease and colorectal cancer, identifying anti-inflammatory and anti-tumor mechanisms that could complement conventional treatments.
Beneficial effect of Xuebijing against Pseudomonas aeruginosa infection in Caenorhabditis elegans
Researchers found that the traditional Chinese medicine formulation Xuebijing protected Caenorhabditis elegans against Pseudomonas aeruginosa infection by enhancing immune pathways and reducing bacterial colonization, providing mechanistic insight into its clinical use for treating sepsis.
The Traditional Chinese Medicine in Treating Diabetic Nephropathy: A Bibliometric Analysis
This bibliometric analysis reviews research trends on Traditional Chinese Medicine for treating diabetic nephropathy. The study identifies key research hotspots including the clinical efficacy of herbal treatments and their pharmacological mechanisms, with improving oxidative stress and regulating gut microbiota highlighted as promising directions for future investigation.
Pharmacodynamic Material Basis and Potential Mechanism Study of Spatholobi Caulis in Reversing Osteoporosis
Researchers investigated the pharmacological mechanisms of Spatholobi Caulis (SC) in reversing osteoporosis, finding it operates through multi-component, multi-target pathways with the AGE-RAGE signaling pathway identified as the primary regulatory mechanism.
[Screening of quality markers and activity verification of Glycyrrhizae Radix et Rhizoma based on small molecule compound-protein interaction].
Researchers screened 27 chemical compounds in licorice root (Glycyrrhizae Radix) to identify quality markers by measuring how strongly each compound binds to mouse organ proteins. Seven active components were identified, and their anti-inflammatory and antioxidant properties were confirmed in a cell model where macrophages were stressed using microplastics.
Exploring the prognostic implications of PET microplastic degradation products in colorectal cancer: insights from an integrated computational analysis on glucocorticoid pathway–mediated mechanisms
Researchers used network toxicology, machine learning, and molecular docking to investigate how PET degradation products—ethylene glycol and terephthalic acid—affect colorectal cancer prognosis through the glucocorticoid signaling pathway. The analysis identified 43 shared target genes, suggesting that PET breakdown products may worsen colorectal cancer outcomes by dysregulating glucocorticoid-mediated anti-inflammatory and cell survival signals.
Highlights
A study examined the therapeutic potential of snail mucus enriched with carob extract, finding in animal models that it could reduce markers of colitis and inflammation, suggesting a novel approach to managing inflammatory bowel conditions using a food-derived bioactive ingredient.
Expression of Th17/Treg Cells in Peripheral Blood and Related Cytokines of Patients with Ulcerative Colitis of Different Syndrome Types and Correlation with the Disease
Researchers found that ulcerative colitis patients with damp-heat syndrome had the highest Th17/Treg imbalance in peripheral blood compared to other syndrome types, with higher Th17 ratios correlating with greater disease severity. These findings provide a quantitative basis for traditional Chinese medicine classification of UC severity.
A lactylation modification-related prediction model for the diagnosis of ulcerative colitis based on machine learning
Scientists used computer analysis to identify four genes linked to a specific chemical process called "lactylation" that appears to play a role in ulcerative colitis, a painful inflammatory bowel disease. They developed a diagnostic test based on these genes that could accurately identify the disease 97.6% of the time. This research could lead to better ways to diagnose ulcerative colitis and potentially new treatments that target this chemical process in immune cells.
Exploring the prognostic implications of PET microplastic degradation products in colorectal cancer: insights from an integrated computational analysis on glucocorticoid pathway–mediated mechanisms
Combining network toxicology, machine learning, and molecular docking, this study found that PET plastic degradation products ethylene glycol and terephthalic acid may influence colorectal cancer prognosis through 43 shared genes linked to TNF/IL-17 signaling and glucocorticoid-mediated metabolic pathways.
Dexmedetomidine alleviates intestinal barrier dysfunction and inflammatory response in mice via suppressing TLR4/MyD88/NF-κB signaling in an experimental model of ulcerative colitis
Researchers investigated whether dexmedetomidine (DEX), a sedative agent, alleviates intestinal barrier dysfunction and inflammatory responses in a mouse model of ulcerative colitis, finding that DEX suppresses the TLR4/MyD88/NF-kB signaling pathway to reduce epithelial cell apoptosis and inflammation. The results suggest that DEX may have therapeutic potential for protecting intestinal barrier integrity in inflammatory bowel conditions.
Erchen Decoction Alleviates High-Fat Diet + AOM/DSS-Induced CRC by Ameliorating Cholesterol-Bile Acid Metabolism Disorder through Regulating FXR and the Gut Microbiota
Researchers found that Erchen Decoction, a traditional Chinese medicine formula, alleviates colorectal cancer progression in a high-fat diet mouse model by correcting cholesterol-bile acid metabolism disorders through modulation of FXR signaling and gut microbiota composition.
Mechanism of Mulberry Leaves and Black Sesame in Alleviating Slow Transit Constipation Revealed by Multi-Omics Analysis
Researchers examined how mulberry leaves and black sesame alleviate slow transit constipation in a mouse model, measuring gut motility, microbiota composition, and intestinal gene expression. Both dietary interventions increased beneficial bacteria, enhanced gut peristalsis, and upregulated genes associated with intestinal motility, supporting their traditional use for digestive health.
Polyethylene terephthalate microplastics exposure enhances the risk of ulcerative colitis: insights from multiomics integration, machine learning, and molecular docking reveal intestinal toxicity mechanisms
Using multiomics integration, machine learning, and molecular docking, this study identified mechanisms by which PET microplastic exposure may increase the risk of ulcerative colitis. Key pathways included intestinal barrier disruption, immune dysregulation, and oxidative stress triggered by PET-MP-protein interactions.
Inhibitory Effects of Jiuzao Polysaccharides on Alcoholic Fatty Liver Formation in Zebrafish Larvae and Their Regulatory Impact on Intestinal Microbiota
Researchers investigated the protective effects of Laowuzeng Jiuzao polysaccharides on ethanol-induced alcoholic fatty liver in zebrafish larvae, finding that the polysaccharides reduced hepatic damage and regulated intestinal microbiota composition, suggesting therapeutic potential for alcohol-related liver disease.
Protective Effect of Paeoniae Radix Alba Carbonisata on Hepatic Amyloidosis by Regulating Calcium Homeostasis
Scientists tested a traditional Chinese herbal medicine called PRAC on a serious liver condition where harmful proteins build up and damage the organ. The herb extract helped protect liver cells and reduced inflammation by fixing problems with calcium balance inside cells. While this is early research done in lab dishes and mice, it suggests this traditional remedy might help treat certain types of liver disease, though human studies are still needed.
Mechanism of P-Hydroxy Benzyl Alcohol Against Cerebral Ischemia Based on Metabonomics Analysis
Researchers investigated how p-hydroxybenzyl alcohol, an active compound from the traditional medicinal plant Gastrodia elata, protects against brain damage caused by reduced blood flow. Using metabolomics in cell and rat models, they identified that the compound works by improving mitochondrial function and reducing excessive autophagy through a specific signaling pathway. The study provides new molecular targets that could inform future treatments for cerebral ischemia.
A computational framework for multi-scale data fusion in assessing the associations between micro- and nanoplastics and human hepatotoxicity
Researchers developed a computational toxicology framework integrating multi-source data and network analysis to map associations between micro- and nanoplastics and hepatotoxicity, identifying key molecular pathways through which MNPs may damage the liver, offering a scalable alternative to traditional in vivo testing.
Preparation of Polysaccharides from Qifuyin and Investigation of Their Anti-Oxidant and Regenerative Effects Based on Planaria
Researchers extracted polysaccharides from the traditional Chinese medicine formula Qifuyin using hydrothermal methods, achieving 29.9% yield and 70.1% purity, and investigated their antioxidant and regenerative effects using planaria as a model organism.
An Adverse Outcome Pathway for food nanomaterial-induced intestinal barrier disruption
Researchers developed an Adverse Outcome Pathway (AOP) linking food nanomaterial ingestion to intestinal barrier disruption, synthesizing existing evidence while identifying critical gaps in standardized testing methods. This framework is directly applicable to nanoplastics, providing a regulatory toxicology tool for assessing how ingested nano-sized plastic particles could damage gut barrier integrity.