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Article
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AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button.
Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Gut & Microbiome
Human Health Effects
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Polyethylene terephthalate microplastics exposure enhances the risk of ulcerative colitis: insights from multiomics integration, machine learning, and molecular docking reveal intestinal toxicity mechanisms
International Journal of Surgery
2025
Xueli Yang,
Bo Yan,
Yu Zhao,
Linxiang Zhou,
Miao Liu,
Gang Chen,
Lei Shen,
Tao Deng
Summary
Using multiomics integration, machine learning, and molecular docking, this study identified mechanisms by which PET microplastic exposure may increase the risk of ulcerative colitis. Key pathways included intestinal barrier disruption, immune dysregulation, and oxidative stress triggered by PET-MP-protein interactions.
This study offers valuable insights into the molecular mechanisms by which PET-MPs may induce UC, providing a theoretical foundation for understanding the potential health risks associated with PET-MPs exposure.