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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Gut & Microbiome Human Health Effects Sign in to save

Polyethylene terephthalate microplastics exposure enhances the risk of ulcerative colitis: insights from multiomics integration, machine learning, and molecular docking reveal intestinal toxicity mechanisms

International Journal of Surgery 2025 Score: 48 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Xueli Yang, Bo Yan, Bo Yan, Yu Zhao, Linxiang Zhou, Linxiang Zhou, Miao Liu, Gang Chen, Gang Chen, Lei Shen, Gang Chen, Gang Chen, Tao Deng

Summary

Using multiomics integration, machine learning, and molecular docking, this study identified mechanisms by which PET microplastic exposure may increase the risk of ulcerative colitis. Key pathways included intestinal barrier disruption, immune dysregulation, and oxidative stress triggered by PET-MP-protein interactions.

Polymers
PE PET
Body Systems
Digestive

This study offers valuable insights into the molecular mechanisms by which PET-MPs may induce UC, providing a theoretical foundation for understanding the potential health risks associated with PET-MPs exposure.

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