We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Single-cell transcriptomic analysis of mouse liver reveals nonparenchymal cells’ intricate responses to PCB126 exposure
ClearSingle-cell transcriptomic analysis reveals heterogeneity of the patterns of responsive genes and cell communications in liver cell populations of zebrafish exposed to polystyrene nanoplastics
Researchers used single-cell gene analysis to examine how polystyrene nanoplastics affect different cell types in zebrafish livers. They discovered that various liver cell populations responded to nanoplastic exposure in distinctly different ways, with some cell types showing more disruption to fat metabolism and stress response genes than others. The study reveals that nanoplastic toxicity in the liver is not uniform and that certain cell populations may be more vulnerable than previously understood.
Single-cell transcriptome analysis of liver immune microenvironment changes induced by microplastics in mice with non-alcoholic fatty liver
Using advanced single-cell analysis, researchers showed that microplastics worsened non-alcoholic fatty liver disease in mice fed a high-fat diet by changing how immune cells behaved in the liver. Microplastic exposure amplified inflammatory responses and altered the communication between different liver cell types. This study is important because it reveals specific immune mechanisms by which microplastics could worsen liver disease, a condition already affecting roughly one in four adults worldwide.
Heterogeneity effects of nanoplastics and lead on zebrafish intestinal cells identified by single-cell sequencing
Researchers used single-cell RNA sequencing to examine how polystyrene nanoplastics and lead individually and together affect different cell types in zebrafish intestines. They found that nanoplastics primarily affected macrophages while lead mostly impacted enterocytes, and the combined exposure showed synergistic effects specifically in goblet cells. The study reveals that population-average toxicity measurements can mask important cell-type-specific responses to environmental contaminants.
Additional file 1 of Single-cell RNA-seq analysis decodes the kidney microenvironment induced by polystyrene microplastics in mice receiving a high-fat diet
Researchers used single-cell RNA sequencing to decode kidney microenvironmental changes induced by polystyrene microplastics in mice fed a high-fat diet, characterizing mural cell and mesangial cell heterogeneity, DEG profiles, and pathway enrichment in affected renal tissue.
Single-cell RNA-seq analysis decodes the kidney microenvironment induced by polystyrene microplastics in mice receiving a high-fat diet
Using advanced single-cell gene analysis, researchers found that mice fed both polystyrene microplastics and a high-fat diet suffered significantly worse kidney damage than either exposure alone. The combination reshaped the kidney's cellular environment, promoting scarring, triggering cancer-related pathways, and altering immune cell populations. This is particularly relevant to human health because many people are simultaneously exposed to microplastics through food and drink while also consuming high-fat diets.
Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice
Researchers used single-cell analysis to map exactly which liver cell types are damaged by triclosan — a common antimicrobial found in personal care products — and found it activates star-shaped cells called hepatic stellate cells, leading to liver scarring (fibrosis). This is the first detailed cellular atlas of triclosan's toxic effects on the liver.
Single-Cell RNA Sequencing Profiling Cellular Heterogeneity and Specific Responses of Fish Gills to Microplastics and Nanoplastics
Using advanced single-cell sequencing, researchers mapped how individual cell types in fish gills respond differently to micro- and nanoplastic exposure. Microplastics mainly affected immune cells called macrophages, while nanoplastics primarily targeted T cells, and a structural cell type called fibroblasts was especially sensitive to microplastics. This detailed cell-level view reveals that plastic particles of different sizes can trigger distinct immune and tissue responses.
Single‐Cell Transcriptomic Analysis Reveals Hair Cell‐Specific Molecular Responses to Polystyrene Nanoplastics in a Zebrafish Embryo Model
Researchers exposed zebrafish embryos to polystyrene nanoplastics at environmentally relevant concentrations and used single-cell RNA sequencing to identify hair cell-specific transcriptional changes in the inner ear, finding molecular-level effects without overt developmental phenotypes.
Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging
Researchers used advanced single-cell techniques to map the different cell types and their spatial arrangement within human bone marrow. The study identified nine distinct non-blood-cell subtypes and revealed how they are organized in specific neighborhoods, providing new insights into how the bone marrow microenvironment supports blood cell production.
4 Single cell RNA-seq samples exposed to nano plastic particles
Researchers used microfluidic chip-based single-cell RNA sequencing to profile the transcriptional responses of human peripheral blood immune cells exposed to carboxylated polystyrene nanoparticles of three sizes (40 nm, 200 nm, or a mixture), providing a cell-type-resolved view of nanoplastic effects on the immune system.
Whole transcriptome sequencing analysis revealed key RNA profiles and toxicity in mice after chronic exposure to microplastics
Researchers examined the long-term effects of environmental levels of microplastics on mice given polystyrene particles in drinking water for 180 days. Whole transcriptome analysis revealed significant changes in RNA expression profiles, with biochemical and histopathological examination showing organ-level impacts. The study suggests that chronic exposure to microplastics at environmentally relevant concentrations can alter key molecular signaling pathways in mammals.
Data mining of molecular data resulting from environmental exposure to xenobiotics
Researchers characterized the multi-layer gene expression response of human airway and liver cells exposed to polystyrene microplastics across multiple doses and time points. They found thousands of differentially expressed genes along with extensive reprogramming of gene isoforms, affecting protein coding capacity and RNA stability. The study demonstrates that microplastic exposure triggers a structured, dose- and time-dependent remodeling of cellular gene expression programs in human tissue models.
Food nutrition and toxicology targeting on specific organs in the era ofsingle-cell sequencing
This review examines how single-cell sequencing technologies can reveal organ-specific effects of food nutrients and toxicants, including contaminants like microplastics, by uncovering cellular heterogeneity and tissue-biased responses that traditional methods miss.
Micro- and nanoplastic (MNPs) exposure at single-cell resolution impaired placental function and cellular dynamics
Researchers performed single-cell transcriptomic analysis of placentas from pregnant women exposed to micro- and nanoplastics, finding that MNP exposure altered trophoblast, macrophage, and fibroblast subpopulations, suggesting impaired placental function through disruption of cell communication and immune regulation.
Single-Cell RNA Sequencing Reveals Size-Dependent Effects of Polystyrene Microplastics on Immune and Secretory Cell Populations from Zebrafish Intestines
Researchers used single-cell RNA sequencing to examine how different sizes of polystyrene microplastics affect intestinal cell populations in zebrafish. The study revealed size-dependent effects on immune and secretory cell populations, providing a detailed transcriptomic view of how microplastics disrupt intestinal function at the individual cell level and alter the interplay between intestinal cells and gut microbiota.
Integrated multi-omics of gut-liver axis to dissect the mechanism underlying hepatotoxicity induced by sub-chronic tire wear particles exposure in mice
Researchers gavaged female mice with tire wear particles (a major microplastic source) at three doses and performed integrated gut-liver multi-omics analysis, finding that sub-chronic exposure disrupted lipid metabolism, promoted liver inflammation, and altered gut microbial communities in a dose-dependent manner.
4 Single cell RNA-seq samples exposed to nano plastic particles
This dataset entry corresponds to single-cell RNA sequencing data from human peripheral blood cells exposed to polystyrene nanoparticles (40 nm, 200 nm, and combined) to characterize size-dependent transcriptional responses in immune cell populations.
Chronic exposure to polyvinyl chloride microplastics induces liver injury and gut microbiota dysbiosis based on the integration of liver transcriptome profiles and full-length 16S rRNA sequencing data
Researchers exposed mice to polyvinyl chloride microplastics for 60 days and found significant liver damage accompanied by changes in gut bacteria composition. Gene expression analysis revealed that the liver injury involved inflammatory and metabolic pathways, while the gut microbiome shifted toward disease-associated bacterial profiles. The study suggests a connection between chronic microplastic exposure, gut health disruption, and liver toxicity.
The Effect of Plastic-Related Compounds on Transcriptome-Wide Gene Expression on CYP2C19-Overexpressing HepG2 Cells
Researchers examined how plastic-related compounds affect gene expression in liver cells overexpressing the drug-metabolizing enzyme CYP2C19, revealing transcriptome-wide changes that suggest plasticizers and additives may disrupt hepatic metabolic pathways.
Molecular LandscapeRemodeling Unravels the Cross-Linksof Microplastics-Induced Lipidomic Fluctuations,Nutrient Disorders and Energy Disarrangements
Mouse liver studies with polypropylene microplastics revealed interconnected disruptions in lipid metabolism, nutrient processing, and energy balance, with proteomic and transcriptomic data highlighting the complexity of hepatic responses to chronic microplastic exposure.
Transcriptomic analysis reveals interactive effects of polyvinyl chloride microplastics and cadmium on Mytilus galloprovincialis: Insights into non-coding RNA responses and environmental implications
Researchers used whole-transcriptome sequencing to study how mussels respond at the molecular level to combined exposure to PVC microplastics and cadmium. They found that the combined pollutants triggered distinct gene expression patterns, particularly in non-coding RNAs involved in immune and stress responses. The study suggests that microplastics and heavy metals together may cause more complex biological effects than either pollutant alone.
Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice
Researchers used multi-omics analysis to reveal that liver injury in colitis mice is linked to intestinal dysbiosis and altered host-microbiota interactions, with gut bacterial shifts correlating to immune and metabolic changes in the liver.
Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice
Researchers used lipidomics and transcriptomics to examine how polystyrene microplastic exposure affects liver lipid metabolism in mice over eight weeks. The study found that while body weight and serum lipid levels were not significantly affected, microplastics caused impaired glucose metabolism and specific changes in hepatic lipid profiles, revealing subtle but measurable disruptions to liver function.
Transcriptional response of short-term nanoplastic exposure in Monodonta labio
Researchers examined the transcriptional response of the intertidal snail Monodonta labio to short-term nanoplastic exposure using RNA sequencing, identifying differentially expressed genes related to immune response, oxidative stress, and metabolism that reveal the molecular mechanisms of nanoplastic toxicity.