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Transcriptomic analysis reveals interactive effects of polyvinyl chloride microplastics and cadmium on Mytilus galloprovincialis: Insights into non-coding RNA responses and environmental implications

Aquatic Toxicology 2024 4 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Shaochong Liu, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Lianzhen Li Shaochong Liu, Lianzhen Li Deliang Yu, Deliang Yu, Willie J.G.M. Peijnenburg, Lianzhen Li Lianzhen Li Lianzhen Li Shaochong Liu, Shaochong Liu, Shaochong Liu, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Lianzhen Li Lianzhen Li Lianzhen Li Lianzhen Li Lianzhen Li Lianzhen Li Lianzhen Li Willie J.G.M. Peijnenburg, Lianzhen Li Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Yaqi Yu, Yanhao Wang, Lianzhen Li Lianzhen Li Lianzhen Li Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Lianzhen Li Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Yanhao Wang, Lianzhen Li Lianzhen Li Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Shaochong Liu, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Shaochong Liu, Xiao Peng, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Lianzhen Li Willie J.G.M. Peijnenburg, Lianzhen Li Lianzhen Li Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Yufeng Yuan, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Lianzhen Li Lianzhen Li Yanhao Wang, Yaqi Yu, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Lianzhen Li Lianzhen Li Xiao Peng, Xiao Peng, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Lianzhen Li Lianzhen Li Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Willie J.G.M. Peijnenburg, Lianzhen Li

Summary

Researchers used whole-transcriptome sequencing to study how mussels respond at the molecular level to combined exposure to PVC microplastics and cadmium. They found that the combined pollutants triggered distinct gene expression patterns, particularly in non-coding RNAs involved in immune and stress responses. The study suggests that microplastics and heavy metals together may cause more complex biological effects than either pollutant alone.

Polymers

PVC

Models

Invertebrate other

Despite increasing concerns regarding the interactions of microplastic and heavy metal pollution, there is limited knowledge on the molecular responses of marine organisms to these stressors. In this study, we used whole-transcriptome sequencing to investigate the molecular responses of the ecologically and economically important bivalve Mytilus galloprovincialis to individual and combined exposures of environmentally relevant concentrations of PVC microplastics and cadmium (Cd). Our results revealed distinct transcriptional changes in M. galloprovincialis, with significant overlap in the differentially expressed genes between the individual and combined exposure groups. Genes involved in cellular senescence, oxidative stress, and galactose metabolism were differentially expressed. Additionally, key signaling pathways related to apoptosis and drug metabolism were significantly modulated. Notably, the interaction of PVC microplastics and Cd resulted in differential expression of genes involved in drug metabolism and longevity regulating compared to single exposures. This suggests that the interaction between these two stressors may have amplified effects on mussel health. Overall, this comprehensive transcriptomic analysis provides valuable insights into the adaptive and detrimental responses of M. galloprovincialis to PVC microplastics and Cd in the environment.

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