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Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice

Military Medical Research 2023 50 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Yunmeng Bai, Fan Yang, Piao Luo, Lulin Xie, Junhui Chen, Yudong Guan, Yudong Guan, Yunmeng Bai, Hongchao Zhou, Jigang Wang Tengfei Xu, Jigang Wang Jigang Wang Huiwen Hao, Huiwen Hao, Bing Chen, Qingshan Geng, Jiahui Zhao, Jigang Wang Cai-Ling Liang, Cai-Ling Liang, Jigang Wang Lingyun Dai, Qingshan Geng, Jigang Wang Jigang Wang

Summary

Researchers used single-cell analysis to map exactly which liver cell types are damaged by triclosan — a common antimicrobial found in personal care products — and found it activates star-shaped cells called hepatic stellate cells, leading to liver scarring (fibrosis). This is the first detailed cellular atlas of triclosan's toxic effects on the liver.

TCS modulates the cellular activities and fates of several specific cell types (including hepatocytes, HSCs, endothelial cells, B cells, Kupffer cells and liver capsular macrophages) in the liver, and regulates the ligand-receptor interactions between these cells, thereby promoting the proliferation and activation of HSCs, leading to liver fibrosis. Overall, we provide the first comprehensive single-cell atlas of mouse livers in response to TCS and delineate the key cellular and molecular processes involved in TCS-induced hepatotoxicity and fibrosis.

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