Papers

61,005 results
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Article Tier 2

Gradual effects of gradient concentrations of polystyrene nanoplastics on metabolic processes of the razor clams

Researchers exposed razor clams to a gradient of polystyrene nanoplastic concentrations and used metabolomics to track effects, finding that even low concentrations disrupted energy metabolism and amino acid pathways, with effects becoming more severe as concentration increased.

2021 Environmental Pollution 47 citations
Article Tier 2

The physiological response of the clam Ruditapes philippinarum and scallop Chlamys farreri to varied concentrations of microplastics exposure

Researchers exposed two types of shellfish (clams and scallops) to polyethylene and PET microplastics and found that both species accumulated the particles in their digestive glands and gills. The exposure caused oxidative stress, disrupted energy and fat metabolism, and damaged tissue, with PET generally being more toxic than polyethylene. Since these are commonly eaten shellfish, the findings raise concerns about microplastic contamination affecting the safety of seafood for human consumers.

2024 Marine Pollution Bulletin 12 citations
Article Tier 2

Are mixtures of micro/nanoplastics more toxic than individual micro or nanoplastic contamination in the clam Ruditapes decussatus?

Researchers exposed clams to polystyrene nanoplastics and polyethylene microplastics, both separately and in combination, to test whether mixtures are more harmful. They found that nanoplastics accumulated more readily in clam tissues and that the mixture caused greater oxidative stress and cellular damage than either type of plastic alone. The study suggests that real-world exposure to multiple plastic particle sizes may be more harmful than exposure to a single type.

2024 Marine Pollution Bulletin 5 citations
Article Tier 2

Impact of polyethylene microplastics on the clam Ruditapes decussatus (Mollusca: Bivalvia): examination of filtration rate, growth, and immunomodulation

Researchers exposed clams to polyethylene microplastics at three different concentrations for 14 days and measured the effects on feeding, growth, and immune function. They found that higher microplastic concentrations reduced the clams' ability to filter water and caused weight loss, while also disrupting immune cell integrity. The study demonstrates that microplastic pollution can impair both the feeding efficiency and immune defenses of shellfish.

2023 Ecotoxicology 18 citations
Article Tier 2

Nanoplastic-Induced Genotoxicity and Intestinal Damage in Freshwater Benthic Clams (Corbicula fluminea): Comparison with Microplastics

Researchers compared the effects of nanoplastics and microplastics on freshwater clams and found that both caused intestinal damage and changes in gut bacteria, but through different biological mechanisms. Nanoplastics triggered cell death through mitochondrial pathways and caused more severe damage to intestinal mucus layers, while microplastics activated immune responses and increased harmful bacteria in the gut. The study suggests that plastic particle size plays a key role in determining the type and severity of biological harm.

2021 ACS Nano 239 citations
Article Tier 2

Microplastics effects in Scrobicularia plana

Researchers exposed clams to polystyrene microplastics for 14 days and found that the particles accumulated in tissues and were not fully eliminated even after a week of depuration in clean water. The microplastics caused measurable oxidative damage, DNA damage, and neurotoxic effects in the clams. The study demonstrates that even short-term microplastic exposure can cause lasting biological harm in marine bivalves.

2017 Marine Pollution Bulletin 474 citations
Article Tier 2

Quantitative assessment of in vivo distribution of nanoplastics in bivalve Ruditapes philippinarum using reliable SERS tag-labeled nanoplastic models

Researchers developed SERS-labeled nanoplastic models to quantitatively track nanoplastic distribution in Manila clams, revealing size-dependent accumulation patterns across different tissues and providing a reliable method for studying nanoplastic bioavailability in bivalves.

2022 Nanoscale 34 citations
Article Tier 2

The stealthy journey of nanoplastics in bivalves: accumulation dynamics and toxic burden

This review examined how bivalves' strong filter-feeding capacity leads to nanoplastic accumulation from surrounding water, covering accumulation dynamics, sub-lethal toxic effects across organ systems, and the implications for aquaculture food safety and bivalve-based environmental monitoring.

2025 Environmental Science Nano 2 citations
Article Tier 2

Exposure to nanoplastics and nanomaterials either single and combined affects the gill-associated microbiome of the Antarctic soft-shelled clam Laternula elliptica

Researchers exposed the Antarctic soft-shell clam Laternula elliptica to polystyrene nanoparticles and nano-titanium dioxide — alone and combined — and found that both nanomaterials shift the gill-associated microbiome toward potentially harmful bacterial taxa, with combined exposure amplifying changes in metabolic functions related to nutrient and DNA processing.

2024 Marine Environmental Research 12 citations
Article Tier 2

Microplastic accumulation and ecological impacts on benthic invertebrates: Insights from a microcosm experiment

In a month-long experiment, researchers exposed marine invertebrates like mussels and clams to small microplastics and found that the particles accumulated mainly in the gut, gills, and reproductive organs. Different species absorbed different types and sizes of microplastics, and bottom-dwelling organisms suffered energy loss from the exposure. Since many of these species are consumed as seafood, their microplastic accumulation represents a direct pathway for human exposure.

2024 Marine Pollution Bulletin 19 citations
Article Tier 2

Microplastics influence physiological processes, growth and reproduction in the Manila clam, Ruditapes philippinarum

Researchers found that Manila clams ingesting polystyrene microplastics accumulated particles in their gills, digestive glands, and intestines, leading to increased respiration and excretion rates while reducing feeding efficiency. Modeling predicted that long-term exposure would significantly reduce shell and flesh growth rates as well as reproductive potential. The study provides evidence that microplastics can fundamentally alter energy allocation and physiological processes in filter-feeding bivalves.

2021 Environmental Pollution 90 citations
Article Tier 2

Trophic transfer effects of PS nanoplastics and field-derived nanoplastics in the freshwater clam Corbicula fluminea

Researchers compared the effects of laboratory-made polystyrene nanoplastics and field-collected nanoplastics on freshwater clams through dietary exposure via algae. They found that both types of nanoplastics transferred through the food chain and accumulated in the clams, but the field-derived particles caused different biological responses than the lab-made ones. The study highlights the importance of using environmentally realistic plastic particles in toxicity research.

2024 Aquatic Toxicology 4 citations
Article Tier 2

Toxic effects of exposure to microplastics with environmentally relevant shapes and concentrations: Accumulation, energy metabolism and tissue damage in oyster Crassostrea gigas

Researchers exposed oysters to irregularly shaped polyethylene and PET microplastics at two concentrations for 21 days and measured accumulation, energy metabolism, and tissue damage. They found that the microplastics accumulated in oyster tissues, disrupted energy metabolism, and caused histological damage, with effects varying by polymer type and concentration. The study suggests that environmentally realistic microplastic shapes and concentrations can cause measurable harm to commercially important shellfish species.

2020 Environmental Pollution 213 citations
Article Tier 2

Microplastics Aggravate the Bioaccumulation of Two Waterborne Veterinary Antibiotics in an Edible Bivalve Species: Potential Mechanisms and Implications for Human Health

Researchers investigated how microplastics affect the bioaccumulation of two veterinary antibiotics, oxytetracycline and florfenicol, in the edible blood clam. The study found that microplastic co-exposure aggravated antibiotic accumulation in the clams, raising concerns about increased health risks for consumers of contaminated shellfish.

2020 Environmental Science & Technology 192 citations
Article Tier 2

Effects of microplastics and mercury on manila clam Ruditapes philippinarum: Feeding rate, immunomodulation, histopathology and oxidative stress

Researchers exposed Manila clams to polyethylene microplastics and mercury, both individually and in combination, to study their effects on feeding, immune response, and tissue health. The study found that while microplastics were ingested and spread to various tissues, they played a negligible role in transporting mercury into the clams. Both pollutants independently reduced filtration rates, impaired immune function, and caused tissue damage in the gills and digestive glands.

2020 Environmental Pollution 148 citations
Article Tier 2

Are microplastics impacting shellfish?

Researchers investigated whether microplastic contamination measurably impacts shellfish physiology, growth, reproduction, and health outcomes, assessing the ecological and food safety implications of microplastic exposure in commercially and ecologically important bivalve species.

2024
Article Tier 2

Scallops seasoned with nanoplastics

Researchers investigated nanoplastic uptake by the great scallop (Pecten maximus) at predicted environmental concentrations using carbon-14 radiotracer labeling to track particle distribution across tissues. The study found that uptake varied by particle size, providing direct evidence that marine bivalves accumulate nanoplastics from their surrounding environment.

2019 Science
Article Tier 2

Fate of Nanoplastics in Marine Larvae: A Case Study Using Barnacles, Amphibalanus amphitrite

Researchers tracked the fate of nanoplastics in barnacle larvae, finding that these tiny particles were ingested and could accumulate in larval tissues, with potential implications for early development and survival of marine invertebrates.

2018 ACS Sustainable Chemistry & Engineering 104 citations
Article Tier 2

Exposure to polystyrene nanoplastics and PCB77 induced oxidative stress, histopathological damage and intestinal microbiota disruption in white hard clam Meretrix lyrata

Researchers exposed white hard clams to nanoplastics and a type of industrial pollutant called PCB77, both individually and together, and found that the combination caused more severe damage than either pollutant alone. The clams showed increased oxidative stress, tissue damage in their gills and digestive glands, and significant disruption of their gut bacteria. The findings suggest that nanoplastics may worsen the toxic effects of other environmental contaminants in shellfish.

2023 The Science of The Total Environment 22 citations
Article Tier 2

In Vitro Toxicity and Modeling Reveal Nanoplastic Effects on Marine Bivalves

Researchers tested the effects of nanoplastics on Manila clams using both lab-based cell experiments and computer modeling, finding that the tiny particles caused growth inhibition, oxidative stress, and DNA damage. The computer models accurately predicted the real-world toxic effects seen in living clams. This approach could speed up safety testing for nanoplastics in seafood species, which matters because clams and other shellfish are a common route of human microplastic exposure.

2024 ACS Nano 14 citations
Article Tier 2

Assessment of Microplastics Contamination in Commericial Clams in the Coastal Zone of Vietnam

Microplastic contamination was assessed in commercially harvested clams from aquaculture farms in coastal Vietnam, a country where microplastic impacts on aquaculture are poorly understood. Both vertebrates and invertebrates in coastal areas were found to ingest microplastics, raising concerns about food safety in Vietnamese seafood.

2021 Applied Ecology and Environmental Research 12 citations
Article Tier 2

Continuum from microplastics to nanoplastics: effects of size and source on the estuarine bivalve Scrobicularia plana

Researchers exposed the estuarine bivalve Scrobicularia plana to environmentally realistic concentrations of both microplastics and nanoplastics to compare their toxic effects. The study found that particle size influenced toxicity profiles differently in gill and digestive gland tissues, suggesting that nanoplastics may pose distinct ecotoxicological risks compared to larger microplastic particles in estuarine organisms.

2023 Environmental Science and Pollution Research 19 citations
Article Tier 2

Combined toxic effects of nanoplastics and norfloxacin on mussel: Leveraging biochemical parameters and gut microbiota

Researchers exposed mussels to nanoplastics and the antibiotic norfloxacin, both alone and together, and found that the combination caused greater biochemical stress than either pollutant alone. Nanoplastics appeared to carry the antibiotic into mussel tissues, increasing its bioavailability and impact on gut microbiota. The findings suggest that nanoplastics can amplify the toxicity of other contaminants in marine organisms.

2023 The Science of The Total Environment 30 citations
Article Tier 2

Study on the toxic effect of seawater-aged microplastics on Philippine curtain clams

Researchers studied how seawater aging changes the properties of five common microplastic types and tested their toxic effects on Philippine curtain clams. Aging significantly increased the surface area of all microplastics and caused visible surface cracking in polyethylene and PVC particles. Higher microplastic concentrations accelerated clam mortality, with prolonged exposure suggesting cumulative toxic effects.

2025 Scientific Reports 1 citations