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61,005 resultsShowing papers similar to Transcriptome analysis of response mechanism to Microcystin-LR and microplastics stress in Asian clam (Corbicula fluminea)
ClearCombining Transcriptomic and Metabolomic Analyses to Investigate the Acute Effects of Microcystin-LR and Nanoplastics of Asian Clams
Researchers combined transcriptomic and metabolomic analyses of river clam hepatopancreas to investigate the individual and combined toxic mechanisms of microcystin-LR and nanoplastics under acute exposure conditions. Integrated analysis of cDNA libraries and metabolites showed significant enrichment of 49, 34, and 44 pathways in microcystin, nanoplastic, and combined treatment groups respectively, revealing distinct and interactive stress response mechanisms.
Evaluation of Microplastics and Microcystin-LR Effect for Asian Clams (Corbicula fluminea) by a Metabolomics Approach
Researchers used a metabolomics approach to investigate the combined effects of microplastics and microcystin-LR on Asian clams, finding that co-exposure caused distinct metabolic responses compared to individual exposures. The study reveals mechanistic interactions between two co-occurring freshwater pollutants at the cellular metabolic level.
Evaluation of Microplastics and Microcystin-LR effect for Asian clams (Corbicula flumine) by a metabolomics approach
Using metabolomics, this study found that combined exposure to microplastics and the cyanotoxin microcystin-LR disrupted multiple metabolic pathways in Asian clams, with effects differing from either stressor alone. This matters because freshwater environments often contain both pollutants simultaneously, and the combined metabolic disruption could impair the health of shellfish consumed by humans.
RNA sequencing provides insights into the effect of dietary ingestion of microplastics and cadmium in the sea cucumber Apostichopus japonicus
Researchers used RNA sequencing to examine combined microplastic and cadmium exposure effects on sea cucumbers, finding that co-exposure caused the most significant gene expression changes and oxidative stress responses, with 1,618 differentially expressed genes identified.
Physiological and transcriptome analysis of Mytilus coruscus in response to Prorocentrum lima and microplastics
The combined effects of diarrhetic shellfish toxin and microplastics on the mussel Mytilus coruscus were assessed at physiological and transcriptomic levels, revealing synergistic disruption of immune function, antioxidant responses, and metabolic pathways. The study provides molecular-level evidence of interactive toxicity between two common coastal contaminants.
Beyond Single Stressors: Integrated Physiological and Transcriptomic Responses of Argopecten irradians Exposed to Polystyrene and Toxic Dinoflagellates
Researchers exposed bay scallops to polystyrene microplastics and toxic algae both individually and in combination, finding that while survival remained above 90%, the combined exposure triggered elevated oxidative stress markers and more complex physiological disruption. Transcriptomic analysis revealed that microplastics primarily interfered with endocrine function while the toxic algae affected immune pathways, and co-exposure produced synergistic effects on metabolism and developmental regulation.
The Combined Effects of Toxic Microcystis aeruginosa and Thermal Stress on the Edible Clam (Corbicula fluminea): Insights into Oxidative Stress Responses and Molecular Networks
Researchers exposed the edible clam Corbicula fluminea to combined thermal stress and toxic Microcystis aeruginosa cyanobacteria, finding that the combined stressors caused greater oxidative stress and physiological disruption than either alone, with implications for bivalve aquaculture during cyanobacterial bloom events.
Multi-Biomarker Responses of Asian Clam Corbicula fluminea (Bivalvia, Corbiculidea) to Cadmium and Microplastics Pollutants
Researchers exposed Asian clams to cadmium, microplastics, and their mixtures, then measured a battery of biomarkers including oxidative stress, energy metabolism, and neurotoxicity indicators. They found that the combined exposure to cadmium and microplastics produced interactive effects that differed from exposure to either contaminant alone. The study demonstrates that microplastics can modify the toxicity of heavy metals in freshwater bivalves, highlighting the importance of studying pollutant mixtures rather than individual contaminants.
Transcriptomic analysis reveals interactive effects of polyvinyl chloride microplastics and cadmium on Mytilus galloprovincialis: Insights into non-coding RNA responses and environmental implications
Researchers used whole-transcriptome sequencing to study how mussels respond at the molecular level to combined exposure to PVC microplastics and cadmium. They found that the combined pollutants triggered distinct gene expression patterns, particularly in non-coding RNAs involved in immune and stress responses. The study suggests that microplastics and heavy metals together may cause more complex biological effects than either pollutant alone.
New insights into the responding mechanism of Eriocheir sinensis hepatopancreas under nanoplastics and copper stress by transcriptome analysis
Researchers used transcriptome analysis to investigate how nanoplastics and copper individually and in combination affect the hepatopancreas of Chinese mitten crabs. They found that co-exposure led to greater accumulation and more severe tissue damage than either pollutant alone, with significant disruptions to immune and metabolic gene pathways. The study suggests that nanoplastics may enhance the toxicity of heavy metals in aquatic organisms through synergistic interactions.
Revealing the Impact of Polystyrene Nanoplastics on Gill Tissues of the Intertidal Clam, Gafrarium Divaricatum (Gmelin, 1791) using Transcriptomics Approach
Researchers exposed intertidal clams to polystyrene nanoplastics and used transcriptomics to assess gill tissue impacts, finding 1,182 upregulated and 1,626 downregulated genes related to immune modulation, antioxidant defense, and apoptosis. Histopathological examination revealed structural damage to gill tissues including ciliary erosion, lamellae fusion, and lipofuscin accumulation. The study establishes a high-quality genomic resource for this clam species while demonstrating the ecotoxicological effects of nanoplastics on sessile marine bivalves.
Transcriptional response in the whiteleg shrimp (Penaeus vannamei) to short-term microplastic exposure
Researchers exposed whiteleg shrimp (Penaeus vannamei) to microplastics for 96 hours and used transcriptomics to profile gene expression changes, finding significant upregulation of stress response, immune, and detoxification pathways, indicating that even short-term microplastic exposure triggers a broad molecular stress response.
Single and repetitive microplastics exposures induce immune system modulation and homeostasis alteration in the edible mussel Mytilus galloprovincialis
Researchers examined transcriptome-wide gene expression changes in Mediterranean mussels after single and repeated microplastic exposures, finding significant immune system modulation and disruption of cellular homeostasis. The study suggests that both short-term and chronic microplastic exposure can alter immune regulation pathways in filter-feeding bivalves, with repeated exposures showing cumulative effects.
Physiological and transcriptomic analyses reveal critical immune responses to hypoxia and sulfide in the haemolymph of clam Tegillarca granosa
This paper is not relevant to microplastics research — it examines how hypoxia and sulfide exposure affect immune responses in blood clams (Tegillarca granosa) at a physiological and transcriptomic level.
Distinguish the toxic differentiations between acute exposure of micro- and nano-plastics on bivalves: An integrated study based on transcriptomic sequencing
Researchers found that nanoplastics are more toxic than microplastics in mussels, causing severe inflammatory responses and greater oxidative stress, with transcriptomic analysis revealing contrasting gene expression patterns between the two particle sizes.
Transcriptomic Analysis Provides Insights into Microplastic and Heavy Metal Challenges in the Line Seahorse (Hippocampus erectus)
Transcriptomic analysis of the seahorse Hippocampus erectus exposed to microplastics and heavy metals (lead, cadmium, copper) revealed distinct gene expression patterns for each contaminant and their combinations. Results identified affected pathways including immunity, metabolism, and oxidative stress, providing molecular insights into combined pollution effects on seahorses.
Responses of Antioxidant Markers and Valve Activity of the Brackish Water Clam Corbicula Japonica Under Single/combined Exposures of Polystyrene Microplastics and Thermal Stress
Researchers exposed the brackish water clam Corbicula japonica to polystyrene microplastics at 200 μg/L and at two temperatures (20°C and 25°C), finding that thermal stress altered valve activity and antioxidant responses, with warmer temperatures increasing microplastic ingestion and changing oxidative damage patterns.
Toxicity of environmental and polystyrene plastic particles on the bivalve Corbicula fluminea: focus on the molecular responses
Researchers exposed freshwater bivalves to environmental microplastics and nanoplastics collected from a river, as well as to laboratory polystyrene nanoparticles, and measured molecular-level responses. Gene expression analysis revealed that plastic particle exposure activated stress response and immune defense pathways in gill and visceral tissues. The study indicates that even environmentally relevant concentrations of plastic particles can trigger measurable biological stress in filter-feeding organisms.
Effects of microplastics and mercury on manila clam Ruditapes philippinarum: Feeding rate, immunomodulation, histopathology and oxidative stress
Researchers exposed Manila clams to polyethylene microplastics and mercury, both individually and in combination, to study their effects on feeding, immune response, and tissue health. The study found that while microplastics were ingested and spread to various tissues, they played a negligible role in transporting mercury into the clams. Both pollutants independently reduced filtration rates, impaired immune function, and caused tissue damage in the gills and digestive glands.
Immunotoxicity of petroleum hydrocarbons and microplastics alone or in combination to a bivalve species: Synergic impacts and potential toxication mechanisms
Marine mussels exposed to petroleum hydrocarbons and microplastics separately and together showed that combined exposure caused greater immune suppression and lysosomal damage than either stressor alone, identifying oxidative stress pathways as a key mechanism of joint toxicity.
Biomarker responses in New Zealand green-lipped mussels Perna canaliculus exposed to microplastics and triclosan
New Zealand green-lipped mussels were exposed to microplastics and triclosan individually and in combination in a 48-hour study, with the combination eliciting greater oxidative stress and immune disruption than either stressor alone.
Molecular Impacts of Dietary Exposure to Nanoplastics Combined or Not with Arsenic in the Caribbean Mangrove Oysters (Isognomon alatus)
Researchers exposed Caribbean mangrove oysters (Isognomon alatus) to three nanoplastic types alone and combined with arsenic and used transcriptomics to measure molecular impacts, finding that nanoplastic-arsenic combinations produced additive or synergistic disruption of detoxification, immune, and metabolic pathways.
Microplastics induce dose-specific transcriptomic disruptions in energy metabolism and immunity of the pearl oyster Pinctada margaritifera
Pearl oysters (Pinctada margaritifera) exposed to three doses of polystyrene microbeads showed dose-dependent reductions in energy balance, and transcriptomic analysis revealed disruptions to pathways controlling immunity and energy metabolism that scaled with exposure concentration.
Impacts of Microplastics, Cadmium, and Their Mixtures on Biochemical Biomarkers in the Freshwater Bivalve Corbicula fluminea (Bivalvia, Corbiculidea)
This study evaluated the combined impacts of microplastics and cadmium on biochemical biomarkers in a freshwater organism, finding that co-exposure caused greater oxidative stress and cellular damage than either contaminant alone. Microplastics appear to enhance cadmium bioavailability and toxicity.