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Evaluation of Microplastics and Microcystin-LR Effect for Asian Clams (Corbicula fluminea) by a Metabolomics Approach
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Researchers used a metabolomics approach to investigate the combined effects of microplastics and microcystin-LR on Asian clams, finding that co-exposure caused distinct metabolic responses compared to individual exposures. The study reveals mechanistic interactions between two co-occurring freshwater pollutants at the cellular metabolic level.
Microplastics (MP) and microcystins (MCs) are two co-occurring pollutants in freshwater ecosystems that pose significant risks to aquatic organisms and human health. This study investigates the interactions between MP and MCs and their effects on the metabolic responses of freshwater aquaculture. Asian clams have been used as an indicator of microplastic pollution in freshwater ecosystems. The present study investigates metabolic responses of Asian clams during microplastic and microcystin-LR stress to identify health impacts and elucidate mechanistic effects of external stressors on Asian clams. A liquid chromatography/mass spectrometry (LC-MS)-based metabolomics approach was used to identify metabolic perturbations and histological section technique was used to assess changes of tissues from different Asian clam treatment groups. The results showed significantly pathological changes in the gills and hepatopancreas in experimental clam compared to control (healthy) clam. Metabolomics revealed alterations of many metabolites in the hepatopancreas of six Asian clam comparison groups, reflecting perturbations in several molecular pathways, including energy metabolism, amino acid metabolism, protein degradation/tissue damage, and oxidative stress. Overall, this study emphasizes the importance of understanding the interactions between MP and MCs and the need for proactive measures to safeguard freshwater ecosystems and human health.
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Evaluation of Microplastics and Microcystin-LR effect for Asian clams (Corbicula flumine) by a metabolomics approach
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Using metabolomics, this study found that combined exposure to microplastics and the cyanotoxin microcystin-LR disrupted multiple metabolic pathways in Asian clams, with effects differing from either stressor alone. This matters because freshwater environments often contain both pollutants simultaneously, and the combined metabolic disruption could impair the health of shellfish consumed by humans.
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Researchers combined transcriptomic and metabolomic analyses of river clam hepatopancreas to investigate the individual and combined toxic mechanisms of microcystin-LR and nanoplastics under acute exposure conditions. Integrated analysis of cDNA libraries and metabolites showed significant enrichment of 49, 34, and 44 pathways in microcystin, nanoplastic, and combined treatment groups respectively, revealing distinct and interactive stress response mechanisms.
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