Papers

20 results
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Article Tier 2

Effects of nano and microplastics on the reproduction system: In vitro and in vivo studies review

This review summarizes both lab and animal studies on how micro and nanoplastics affect the reproductive system in males and females. Evidence shows that microplastics can reduce sperm quality, damage ovaries, disrupt hormone levels, and even cross the placenta during pregnancy. The findings raise significant concerns about how widespread microplastic exposure might contribute to fertility problems and reproductive health issues in humans.

2023 Food and Chemical Toxicology 38 citations
Article Tier 2

Toxicological effects of micro/nano-plastics on human reproductive health: A review

This review summarizes research on how micro- and nanoplastics affect human reproductive health in both men and women. Evidence from animal and lab studies shows that these particles can accumulate in reproductive organs, disrupt hormones, damage eggs and sperm, and cause inflammation and oxidative stress. While human studies are still limited, the growing body of evidence suggests that microplastic exposure is a potential threat to fertility that warrants further investigation.

2025 Toxicology Letters 7 citations
Article Tier 2

Adverse effects of microplastics and nanoplastics on the reproductive system: A comprehensive review of fertility and potential harmful interactions

This review summarizes how microplastics and nanoplastics can harm both male and female reproductive systems by disrupting hormone signaling, damaging sperm and egg cells, and causing inflammation in reproductive tissues. Smaller nanoplastics are especially concerning because they can cross biological barriers more easily and reach the testes and ovaries. With global infertility rates rising, the authors highlight environmental plastic exposure as a factor that deserves more research attention.

2023 The Science of The Total Environment 99 citations
Review Tier 2

"Unseen Dangers: The Effects of Micro- and Nanoplastics on Human Reproductive Health - A Narrative Review"

This review examines the effects of micro- and nanoplastics on human reproductive health, covering evidence from in vitro, animal, and epidemiological studies showing that plastic particles can disrupt hormone signaling, sperm function, ovarian development, and placental integrity.

2025 Recent Advances in Inflammation & Allergy Drug Discovery
Article Tier 2

Understanding the impact of nanoplastics on reproductive health: Exposure pathways, mechanisms, and implications

This review summarizes existing research on how nanoplastics (tiny plastic particles smaller than one micrometer) affect reproductive health in animals and potentially humans. Studies show that nanoplastics can accumulate in reproductive organs including the placenta, and evidence from animal studies links exposure to hormone disruption, reduced fertility, and developmental problems. The authors highlight a significant knowledge gap about nanoplastic effects on human reproduction, despite growing evidence that these particles reach our reproductive systems.

2024 Toxicology 16 citations
Review Tier 2

Microplastics and human fertility: A comprehensive review of their presence in human samples and reproductive implication

This review examines the growing evidence linking microplastic and nanoplastic exposure to potential effects on human fertility. Researchers noted that these tiny plastic particles have been detected in blood, placenta, and seminal fluid, suggesting continuous systemic exposure and the ability to cross key biological barriers. Animal studies indicate that microplastics may affect reproductive health through oxidative stress, hormonal disruption, and tissue damage, though more standardized human research is needed.

2025 Ecotoxicology and Environmental Safety 2 citations
Clinical Trial Tier 1

Reproductive toxicity and related mechanisms of micro(nano)plastics in terrestrial mammals: Review of current evidence.

This review of terrestrial mammal studies found that micro- and nanoplastics induce reproductive toxicity through oxidative stress, inflammation, endocrine disruption, and DNA damage, affecting both male and female fertility. In males, effects include blood-testis barrier disruption and impaired spermatogenesis, while females show compromised oocyte maturation, ovarian fibrosis, and diminished ovarian reserve, with particles also capable of crossing the maternal-fetal interface.

2024 Ecotoxicology and environmental safety
Article Tier 2

Plastic pollution in human reproduction: should we worry?

Researchers reviewed evidence that micro- and nanoplastics can cross the placenta, enter amniotic fluid, and accumulate in reproductive tissues in both men and women. Animal and cell studies suggest these particles may reduce egg and sperm quality and harm fetal development, though most experiments use higher doses than people realistically encounter.

2025 Reproductive BioMedicine Online
Systematic Review Tier 1

The emerging risk of microplastics and nanoplastics on the microstructure and function of reproductive organs in mammals: A systematic review of preclinical evidence

Preclinical evidence from 12 studies shows micro- and nanoplastics accumulate in mammalian gonads, causing dose-dependent damage including seminiferous degeneration, sperm malformation, reduced follicular growth, and impaired hormone levels through pro-oxidant and pro-inflammatory mechanisms.

2022 Life Sciences 94 citations
Article Tier 2

Research Progress in Reproductive Toxicity of Micro- and Nanoplastics on Males and Its Mechanisms

This review summarized research on the reproductive toxicity of micro- and nanoplastics (MNPs) in males, finding that MNPs accumulate in reproductive organs and cause toxicity through oxidative stress, hormonal disruption, and DNA damage, with implications for both animal and human reproductive health.

2025 Hans Journal of Food and Nutrition Science
Article Tier 2

Unraveling the threat: Microplastics and nano-plastics' impact on reproductive viability across ecosystems

This review summarizes research on how microplastics and nanoplastics affect reproduction across many species, from aquatic invertebrates to mammals including humans. In males, exposure leads to testicular damage, lower sperm quality, and hormone disruption; in females, it causes ovarian and uterine problems, inflammation, and reduced fertility. The evidence also shows these reproductive harms can be passed to offspring, raising serious concerns about long-term effects on human fertility.

2023 The Science of The Total Environment 44 citations
Article Tier 2

Concerning influences of micro/nano plastics on female reproductive health: focusing on cellular and molecular pathways from animal models to human studies

This review summarizes research showing that micro- and nanoplastics can harm the female reproductive system in multiple ways, from reducing ovarian reserves and disrupting hormone balance to accumulating in the placenta and breast milk. Animal studies show these particles trigger oxidative stress and inflammation in reproductive tissues, and human studies have confirmed their presence in placental tissue and infant feces, raising concerns about effects on fertility and fetal development.

2024 Reproductive Biology and Endocrinology 38 citations
Article Tier 2

The impact of microplastics on female reproduction and early life

This review examined the current evidence on how micro- and nanoplastics may affect female reproduction and early life development. Researchers found that studies in animals suggest microplastics can cross important biological barriers and may interfere with reproductive processes, though human data remains very limited. The study highlights the urgent need for standardized methods to measure human exposure and better understand potential reproductive health effects.

2023 Animal Reproduction 38 citations
Article Tier 2

The reproductive and transgenerational toxicity of microplastics and nanoplastics: A threat to mammalian fertility in both sexes

This review examines how microplastics and nanoplastics can accumulate in reproductive organs and harm fertility in both males and females. In animal studies, exposure led to damaged sperm, disrupted hormones, and abnormal ovary and uterus structure. Offspring of exposed mothers also showed metabolic problems, immune issues, and cognitive disorders, suggesting these particles may affect future generations.

2023 Journal of Applied Toxicology 65 citations
Article Tier 2

The hidden threat: Unraveling the impact of microplastics on reproductive health

This review summarizes how microplastics disrupt the reproductive system in both males and females by interfering with hormone signaling, damaging the blood-testis barrier, impairing sperm production, and causing problems in the ovaries and uterus. The authors also note that microplastic exposure may affect offspring development, including their future reproductive capacity and metabolism.

2024 The Science of The Total Environment 71 citations
Clinical Trial Tier 1

A review of the impact of micro‐ and nanoplastics on female reproduction: What we know and gaps in knowledge

This review examines what is known about how micro- and nanoplastics affect female reproductive health. Animal studies show these particles accumulate in ovarian tissue, disrupt hormones, and cause oxidative stress, leading to hormonal imbalances and ovarian damage, though research in humans is still limited.

2025 International Journal of Gynecology & Obstetrics
Article Tier 2

Investigation of potential detrimental effects of nano- and microplastics in human endometrial stromal cells

This review examined potential detrimental effects of nano- and microplastics in human reproductive health, assessing in vitro and animal studies showing disruption to sperm motility, hormonal signaling, and embryonic development. The authors conclude that reproductive toxicity is a plausible concern but emphasize the lack of direct human clinical evidence.

2024 Research Square (Research Square)
Systematic Review Tier 1

Unravelling the potential mechanisms of nano- and microplastic toxicity to the male reproductive system: A systematic review

This systematic review found that micro- and nanoplastics accumulate in the testes and epididymis in rodent models, disrupting the blood-testis barrier, increasing germ cell death, reducing sperm motility, and causing hormone imbalance through oxidative stress and inflammation. Smaller nanoplastics penetrate tissues more readily for molecular disruption, while larger microplastics cause greater structural damage.

2025 Reproductive Toxicology 2 citations
Systematic Review Tier 1

Exposure to micro- and nanoplastics and human reproductive outcomes: a systematic review

This systematic review summarizes existing research on whether micro and nanoplastics affect human fertility and pregnancy outcomes. While the evidence is still emerging, the review found that these particles have been detected in placenta and fetal tissue, raising important questions about potential effects on reproductive health that warrant further study.

2023 1 citations
Article Tier 2

The Microplastics and Human Health: Focus on the Reproductive System

This review examined evidence that microplastics accumulate in human reproductive tissues and evaluated their potential effects on fertility and reproductive health. The authors found microplastics detected in testes, ovaries, placenta, and semen, and summarized mechanistic evidence linking them to hormonal disruption, oxidative stress, and impaired gamete function.

2025 Quality in Sport