Papers

61,005 results
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Article Tier 2

Quantitative Tracking of Nanoplastic Uptake and Distribution in Zebrafish by Single-Particle Inductively Coupled Plasma Mass Spectrometry

Researchers developed a new method to track nanoplastics at the single-particle level in zebrafish using europium-doped polystyrene particles and mass spectrometry. They found that while most nanoplastics accumulated in the intestine, particles continuously penetrated into internal organs including the brain, demonstrating the ability to cross the blood-brain barrier. The study suggests that nanoplastics pose a systemic exposure risk, though the chorion of fish eggs appears to block their entry.

2025 Analytical Chemistry 1 citations
Article Tier 2

Uptake, bioaccumulation, biodistribution and depuration of polystyrene nanoplastics in zebrafish (Danio rerio)

Researchers used advanced mass spectrometry to track how polystyrene nanoplastics accumulate in and are cleared from zebrafish tissues over time. The nanoplastics concentrated most in the intestine, liver, and gills, with only partial clearance after the exposure ended. This study provides important data on how persistent nanoplastics can be in living organisms, which helps scientists better assess the long-term risks of plastic particle exposure.

2023 The Science of The Total Environment 53 citations
Article Tier 2

Biodistribution of europium-doped polystyrene nanoplastics in a model invertebrate organism

This study used europium-doped polystyrene nanoplastics tracked by laser ablation inductively coupled plasma mass spectrometry to map biodistribution of plastic nanoparticles in a model invertebrate organism. The labeled tracer approach enabled precise organ-level mapping of nanoplastic distribution, revealing where plastic nanoparticles accumulate after exposure.

2024 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Qualitative and quantitative analysis of accumulation and biodistribution of polystyrene nanoplastics in zebrafish (Danio rerio) via artificial freshwater

Researchers developed MALDI-TOF mass spectrometry methods to accurately track polystyrene nanoplastic accumulation and biodistribution across zebrafish tissues after waterborne exposure, enabling precise quantitative analysis of nanoplastic uptake.

2023 Environmental Science Nano 8 citations
Article Tier 2

Biodistribution of europium-doped polystyrene nanoplastics in a model invertebrate organism

This study tracked the biodistribution of europium-labeled polystyrene nanoplastics in a model invertebrate using laser ablation ICP-MS, overcoming the analytical challenge of distinguishing nanoplastics from surrounding biological material in tissues. Organ-specific accumulation patterns were mapped, providing mechanistic data on nanoplastic fate after uptake in a small animal model.

2024 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Fluorescent Polypropylene Nanoplastics for Studying Uptake, Biodistribution, and Excretion in Zebrafish Embryos

Researchers developed a method to produce fluorescent polypropylene nanoplastics and tracked their movement in zebrafish embryos. The study found that the nanoplastics were ingested, distributed in the intestine, and eventually excreted, providing a new tool for assessing the biological risks of environmentally relevant plastic particles at the nanoscale.

2022 ACS Omega 46 citations
Article Tier 2

Europium-labelled nanopolystyrene as model nanoplastics for environmental fate investigations: Synthesis and optimisation

Researchers developed a method to track nanoplastics in the environment by embedding the rare-earth element europium into polystyrene nanoparticles, enabling precise detection using single-particle mass spectrometry even at very low concentrations. The europium label stayed locked inside the particles for over a week in both fresh and salt water, making this a reliable tool for studying how nanoplastics move and persist in ecosystems.

2025 Polymer Testing
Article Tier 2

Quantitative assessment and monitoring of microplastics and nanoplastics distributions and lipid metabolism in live zebrafish using hyperspectral stimulated Raman scattering microscopy

Researchers developed a new imaging technique to watch microplastics and nanoplastics accumulate in live zebrafish in real time, without needing dyes or labels. They found that these tiny plastic particles built up in the fish's digestive system and disrupted fat metabolism, providing direct visual evidence of how micro- and nanoplastics can interfere with basic biological processes.

2024 Environment International 20 citations
Article Tier 2

Ultrastable long-term tracking and quantification of nanoplastics in complex environmental matrices

Researchers developed a europium-based tracer system for long-term tracking and quantification of nanoplastics in water, sediment, and organisms. The method demonstrated high stability over 28 days and enabled detection at concentrations as low as 0.5 micrograms per liter, revealing that over 95 percent of nanoplastic particles settled into sediment within 10 days in experimental conditions.

2026 Journal of Hazardous Materials
Article Tier 2

Imaging and quantifying the biological uptake and distribution of nanoplastics using a dual-functional model material

Researchers developed a dual-functional nanoplastic model material that allows both imaging and precise quantification of nanoplastic uptake in biological systems. Using surface-enhanced Raman spectroscopy and inductively coupled plasma mass spectrometry, they could track where nanoplastics accumulated in organisms at high resolution. The tool addresses a major gap in nanoplastic research by enabling more accurate measurement of how these tiny particles interact with living tissues.

2024 2 citations
Article Tier 2

Development of Water Cluster-Secondary Ion Mass Spectrometry and Particle Induced X-ray Emission to Investigate Spatially Resolved Biological Responses to Nanopolystyrene in Zebrafish Larvae

Researchers developed advanced imaging techniques using water cluster-secondary ion mass spectrometry and particle-induced X-ray emission to study how nanoplastics interact with zebrafish larvae at the tissue level. They mapped the spatial distribution of elements and molecular changes in organs exposed to nanopolystyrene at environmentally realistic concentrations. The study provides new analytical methods for understanding how nanoplastics are taken up and distributed in living organisms, filling a critical gap in nanoplastic toxicology research.

2026
Article Tier 2

Bioaccumulation of various nanoplastic particles in larval zebrafish (Danio rerio)

Researchers exposed larval zebrafish (Danio rerio) to 40-60 nm and 100 nm polystyrene nanoplastic particles using standard fish embryo toxicity and general behavioral toxicity assays from 6-120 hours post-fertilization, combining toxicity endpoints with fluorescence microscopy to confirm particle uptake and excretion. The study demonstrated nanoplastic accumulation within zebrafish larvae at tested concentrations, providing mechanistic insights into aquatic organism exposure dynamics for nanoplastics.

2022 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

A Novel Strategy for the Detection and Quantification of Nanoplastics by Single Particle Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

A new analytical method was developed to detect and count individual nanoplastic particles in drinking water and river water using gold nanoparticles as tags and single particle ICP-MS for detection. The method can detect nanoplastics as small as 135 nm at environmentally relevant concentrations, providing a sensitive new tool for tracking nanoplastic contamination.

2020 Analytical Chemistry 152 citations
Article Tier 2

Size-dependent and tissue specific accumulation of polystyrene microplastics and nanoplastics in zebrafish

Researchers tracked size-dependent accumulation of polystyrene micro- and nanoplastics in multiple zebrafish tissues, finding that smaller particles distributed more broadly throughout the body compared to larger ones. Nanoplastics showed greater systemic distribution including into brain and reproductive tissues, raising concerns about size-dependent health risks.

2025 Aquatic Toxicology
Article Tier 2

Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish

Researchers tracked the accumulation and distribution of fluorescent microplastics in early life stages of a freshwater organism, finding that microplastics were taken up and distributed across body tissues. The results help explain how microplastics accumulate in young aquatic organisms and potentially affect their development.

2021 Journal of Visualized Experiments 5 citations
Article Tier 2

Tracking of realistic nanoplastics in complicated matrices by iridium element labeling and inductively coupled plasma mass spectroscopy

Researchers developed a protocol to track realistic nanoplastics in environmental and biological samples by labeling them with an iridium-containing agent and detecting them via inductively coupled plasma mass spectroscopy, demonstrating stable tracking across complex matrices.

2021 Journal of Hazardous Materials 31 citations
Article Tier 2

Quantification of palladium-labelled nanoplastics algal uptake by single cell and single particle inductively coupled plasma mass spectrometry

Researchers developed a method using palladium-labelled nanoplastics and single-cell mass spectrometry to quantify nanoplastic uptake by algal cells. The study demonstrated that this technique can measure nanoplastic exposure on a per-cell basis, providing a valuable new tool for understanding how nanoplastics interact with organisms at the base of aquatic food webs.

2024 Environmental Chemistry 2 citations
Article Tier 2

Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio)

Researchers tracked the uptake and distribution of polystyrene nanoparticles in developing zebrafish and found that the particles accumulated in the yolk sac and then spread to the brain, liver, heart, and other organs. While the nanoparticles did not cause significant mortality or deformities, they did reduce heart rate and alter swimming behavior. The study suggests that nanoplastics can penetrate biological barriers and accumulate in multiple tissues during early development.

2017 Aquatic Toxicology 614 citations
Article Tier 2

Uptake Routes and Biodistribution of Polystyrene Nanoplastics on Zebrafish Larvae and Toxic Effects on Development

Researchers exposed zebrafish embryos and larvae to amino-modified polystyrene nanoplastics to study uptake routes and biodistribution. The study found that nanoplastics accumulated in target organs and caused toxic developmental effects, providing evidence that these tiny plastic fragments can penetrate biological barriers and interfere with normal development in aquatic organisms.

2023 Fishes 17 citations
Article Tier 2

Uptake, distribution and elimination of palladium-doped polystyrene nanoplastics in rainbow trout (Oncorhynchus mykiss) following dietary exposure

Researchers tracked the uptake, tissue distribution, and elimination of palladium-doped polystyrene nanoplastics in rainbow trout during dietary exposure and depuration. The study found that nanoplastics accumulated primarily in the intestinal tissues and were also detected in the liver, gallbladder, and kidney, with incomplete clearance after the depuration period.

2022 The Science of The Total Environment 46 citations
Article Tier 2

Recognition and movement of polystyrene nanoplastics in fish cells

Researchers tracked how zebrafish cells take up, transport, and release three types of polystyrene nanoplastics with different surface modifications. They found that cell uptake peaked within two hours and occurred mainly through specific cellular pathways, with the particles initially entering the cytoplasm before being transported to lysosomes. The nanoplastics were retained in cells for 10 to 15 hours depending on surface chemistry, highlighting the importance of understanding how these particles move through biological systems.

2022 Environmental Pollution 40 citations
Article Tier 2

MassBalance Tracing of In Vivo Biodistribution,Relocation, and Excretion of Europium-Doped Micro/Nanoplastics inRats

This rat study used europium-labeled micro- and nanoplastics to track particle distribution in the body after intravenous administration, finding that most accumulated in the liver and spleen with very little reaching the brain or heart. The results suggest that standard biological filtration processes govern microplastic distribution following classical size-dependent rules.

Figshare
Article Tier 2

14 C-labelled nanoplastics reveal size-dependent bioaccumulation in juvenile rainbow trout ( Oncorhynchus mykiss )

Researchers used carbon-14-labelled nanoplastics to track size-dependent uptake, biodistribution, and elimination in juvenile rainbow trout at environmentally relevant concentrations. The study found that 20 nm particles translocated across gut tissue into internal organs, while larger 250 nm particles did not, demonstrating that nanoplastic bioaccumulation is strongly size-dependent even at very low exposure levels.

2026 Oxford University Research Archive (ORA) (University of Oxford)
Article Tier 2

Quantitative monitoring of microplastics and lipid metabolism in live zebrafish via hyperspectral stimulated Raman scattering microscopy

Researchers used spectral focusing hyperspectral stimulated Raman scattering (SRS) microscopy to longitudinally monitor microplastic uptake, size-dependent organ accumulation, and lipid metabolic changes in live zebrafish during development. They found that microplastic exposure disrupted hepatic lipid metabolism and energy homeostasis, with the SRS imaging approach enabling real-time, label-free tracking of microplastics and associated biochemical changes in living organisms.

2024