We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Uptake, bioaccumulation, biodistribution and depuration of polystyrene nanoplastics in zebrafish (Danio rerio)
Summary
Researchers used advanced mass spectrometry to track how polystyrene nanoplastics accumulate in and are cleared from zebrafish tissues over time. The nanoplastics concentrated most in the intestine, liver, and gills, with only partial clearance after the exposure ended. This study provides important data on how persistent nanoplastics can be in living organisms, which helps scientists better assess the long-term risks of plastic particle exposure.
Plastic nanoparticles formed from both daily use of plastics and their wastes have emerged as a potential health and environmental hazard. It is necessary to study the biological process of nanoplastics in ecological risk assessment. To address this concern, we quantitatively investigated the accumulation and depuration of polystyrene nanoplastics (PSNs) in the tissues of zebrafish after the aquatic exposure using a quantitative method based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Via the PSNs-spiked freshwater, zebrafish were exposed to three different concentrations of PSNs for 30 days, followed by 16 days of depuration. The results showed that the amounts of PSNs accumulated in zebrafish tissues were in the following order: intestine > liver > gill > muscle > brain. The uptake and depuration of PSNs in zebrafish both followed pseudo-first-order kinetics. It was revealed that the bioaccumulation was concentration, tissue and time dependent. When the PSNs concentration is low, the steady state might take longer time (or not occur) than that of a high concentration. After 16 days of depuration, there were still some PSNs present in the tissues particularly in the brain, where it might take 70 days or more to remove 75 % of PSNs. Overall, this work offers important knowledge on the bioaccumulation of PSNs, which may be useful for future studies into the health hazards of PSNs in aquatic environments.
Sign in to start a discussion.
More Papers Like This
Qualitative and quantitative analysis of accumulation and biodistribution of polystyrene nanoplastics in zebrafish (Danio rerio) via artificial freshwater
Researchers developed MALDI-TOF mass spectrometry methods to accurately track polystyrene nanoplastic accumulation and biodistribution across zebrafish tissues after waterborne exposure, enabling precise quantitative analysis of nanoplastic uptake.
Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver
Researchers exposed zebrafish to polystyrene microplastics of two different sizes and tracked where the particles accumulated in the body. They found that smaller particles (5 micrometers) built up in the gills, liver, and gut, while larger particles (20 micrometers) mainly stayed in the gills and gut. The microplastics caused liver inflammation, oxidative stress, and disrupted fat metabolism, suggesting that ingested microplastics can damage internal organs in fish.
Uptake, distribution and elimination of palladium-doped polystyrene nanoplastics in rainbow trout (Oncorhynchus mykiss) following dietary exposure
Researchers tracked the uptake, tissue distribution, and elimination of palladium-doped polystyrene nanoplastics in rainbow trout during dietary exposure and depuration. The study found that nanoplastics accumulated primarily in the intestinal tissues and were also detected in the liver, gallbladder, and kidney, with incomplete clearance after the depuration period.
Quantitative Tracking of Nanoplastic Uptake and Distributionin Zebrafish by Single-Particle Inductively Coupled Plasma Mass Spectrometry
Researchers developed a framework using europium-doped polystyrene nanoplastics as tracers, combined with single-particle inductively coupled plasma mass spectrometry, to quantitatively track nanoplastic uptake and distribution in zebrafish at the single-particle level. This method enabled real-time, size-resolved tracking of nanoplastics accumulating in different fish organs over time.
Quantitative Tracking of Nanoplastic Uptake and Distribution in Zebrafish by Single-Particle Inductively Coupled Plasma Mass Spectrometry
Researchers developed a new method to track nanoplastics at the single-particle level in zebrafish using europium-doped polystyrene particles and mass spectrometry. They found that while most nanoplastics accumulated in the intestine, particles continuously penetrated into internal organs including the brain, demonstrating the ability to cross the blood-brain barrier. The study suggests that nanoplastics pose a systemic exposure risk, though the chorion of fish eggs appears to block their entry.