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Quantitative monitoring of microplastics and lipid metabolism in live zebrafish via hyperspectral stimulated Raman scattering microscopy
Summary
Researchers used spectral focusing hyperspectral stimulated Raman scattering (SRS) microscopy to longitudinally monitor microplastic uptake, size-dependent organ accumulation, and lipid metabolic changes in live zebrafish during development. They found that microplastic exposure disrupted hepatic lipid metabolism and energy homeostasis, with the SRS imaging approach enabling real-time, label-free tracking of microplastics and associated biochemical changes in living organisms.
We utilize spectral focusing hyperspectral stimulated Raman scattering (SRS) imaging for longitudinally assessment of the interactions between live zebrafish and microplastics (MP) throughout the development process. Our study delves into the pathways of MP uptake and the size-dependent accumulation of MP within different zebrafish organs during various developmental phases. The altered lipid metabolic dynamics uncovered by Raman-tagged hyperspectral SRS imaging further reveal the hepatic inflammation and disruptions in energy metabolism within MP-exposed zebrafish, providing fresh insights on the potential impacts and fate of MP on diverse living organisms.