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20 resultsShowing papers similar to Intratumoural microbiota: from theory to clinical application
ClearTumour-infiltrating microplastics disrupt the JAK-STAT-microbiota axis to promote immunotherapy resistance in colorectal cancer
Researchers isolated microplastics from colorectal cancer tumor tissues and blood samples and examined their properties and effects on cancer progression. They found that tumor-infiltrating microplastics disrupted the JAK-STAT signaling pathway and altered gut microbiota composition, potentially reducing the effectiveness of immunotherapy. The study suggests that microplastic presence in tumors may be a factor worth investigating in cancer treatment outcomes.
Tumour-associated macrophages: versatile players in the tumour microenvironment
This review explores tumour-associated macrophages, immune cells that play complex and sometimes contradictory roles in cancer, both helping tumours grow and fighting them. Researchers describe newly discovered behaviors of these cells, including their ability to transform into other cell types. The study highlights the potential of targeting these macrophages as a strategy in cancer immunotherapy.
Microscopic menace: exploring the link between microplastics and cancer pathogenesis
This review examines the growing evidence linking microplastic exposure to cancer development in humans. Microplastics can accumulate in the body and trigger inflammation, oxidative stress, and other biological changes associated with tumor growth. While more clinical research is needed, the review highlights that microplastics should be taken seriously as a potential factor in cancer risk.
Role of microplastics in the tumor microenvironment (Review)
This review examines how microplastics may help tumors grow by influencing the environment around cancer cells. Microplastics can interact with immune cells, connective tissue cells, blood vessel cells, and the tissue scaffolding around tumors in ways that may promote cancer progression and inflammation. While more research is needed, the findings raise important questions about whether chronic microplastic exposure could affect cancer development in humans.
Microplastics: an often-overlooked issue in the transition from chronic inflammation to cancer
This review explores how microplastics that accumulate in the human body may trigger long-lasting inflammation, which is a known driver of cancer development. The authors describe how microplastics can disrupt the gut microbiome, activate immune responses, and alter signaling pathways in ways that could promote tumor growth over time.
The Human Archaeome: Commensals, Opportunists, or Emerging Pathogens?
This review examines the human archaeome—archaeal microorganisms inhabiting the gut, skin, and other body sites—and their potential roles in health and disease. It finds no conclusive archaeal pathogens in humans but identifies indirect roles through metabolic interactions with bacteria, relevant to gut microbiome research.
Converging frontiers in cancer treatment: the role of nanomaterials, mesenchymal stem cells, and microbial agents—challenges and limitations
This review examines three cutting-edge approaches to cancer treatment: nanomaterials for targeted drug delivery, mesenchymal stem cells as carriers for therapeutic agents, and microbial agents that can selectively attack tumors. Each approach aims to overcome the limitations of conventional treatments like chemotherapy and radiation, which often damage healthy tissue and lead to drug resistance. The authors discuss both the promise and the remaining challenges of bringing these innovative therapies into clinical practice.
Microplastics: An emerging environmental risk factor for gut microbiota dysbiosis and cancer development?
This review examines how microplastics may disrupt the gut microbiome and immune system in ways that could promote cancer development. Evidence from recent studies suggests microplastics can cause chronic inflammation, alter the balance of gut bacteria, and trigger molecular pathways linked to several cancer types including lung, liver, breast, and colon cancer. While more human research is needed, the review highlights a concerning connection between microplastic exposure, gut health, and cancer risk.
Extracellular Vesicles & Co.: scaring immune cells in the TME since ever
This review explores how extracellular vesicles and other secreted particles in the tumor microenvironment help cancer cells evade the immune system. Researchers described the various ways these tiny cell-derived packages carry signals that suppress immune responses and promote tumor growth. The study provides a broad overview of how intercellular communication in tumors undermines the body's natural defenses against cancer.
Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies
Researchers review how nanoscale materials — tiny particles engineered at the billionth-of-a-meter scale — offer a promising alternative to traditional antibiotics as bacteria develop resistance to conventional drugs. These "nanobiotics" can penetrate bacterial defenses and biofilms in ways that standard antibiotics cannot, potentially helping avert a global post-antibiotic health crisis.
Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity
This review examines how nanotechnology-based approaches can regulate lipid metabolism in tumor microenvironments to enhance anti-cancer immune responses, covering lipid nanoparticles, liposomes, and other delivery systems. The authors identify lipid metabolic reprogramming as a promising immunotherapy target and nanotechnology as a key enabler for delivering therapeutics that reshape tumor-associated metabolic pathways.
Detection and quantification of microplastics in various types of human tumor tissues
Researchers detected microplastics in 43% of tumor samples across lung, gastric, colorectal, cervical, and pancreatic cancers, with polystyrene, PVC, and polyethylene being the types found. In pancreatic tumors, microplastic presence was associated with fewer immune cells that fight cancer and more immune cells linked to tumor progression, suggesting microplastics may create conditions that help tumors evade the immune system.
The micro(nano)plastics perspective: exploring cancer development and therapy
This review explores the emerging link between microplastics and cancer development. Microplastics can trigger chronic inflammation, oxidative stress, and hormone disruption, all of which are known pathways that may promote cancer growth. Interestingly, researchers are also studying whether engineered microplastics could be used as drug carriers for cancer therapy, though long-term effects remain unclear.
mTOR Signaling Pathway and Gut Microbiota in Various Disorders: Mechanisms and Potential Drugs in Pharmacotherapy
This review summarizes how the mTOR signaling pathway, a master regulator of cell growth and metabolism, interacts with gut bacteria to influence a wide range of diseases. Disruptions to gut microbiota can trigger mTOR-related problems linked to cancer, diabetes, and inflammatory conditions. While not focused on microplastics directly, this pathway is relevant because microplastic exposure is known to disrupt gut bacteria and may contribute to mTOR-related health issues.
Pollutants, microbiota and immune system: frenemies within the gut
This review summarizes how environmental pollutants, including microplastics, disrupt the gut microbiome and immune system, potentially contributing to inflammatory bowel diseases and colorectal cancer. Pollutants reduce beneficial gut bacteria while promoting inflammation, weakening the intestinal barrier, and triggering a chain of events that can push cells toward cancerous growth.
Who inhabits the built environment? A microbiological point of view on the principal bacteria colonizing our urban areas
Researchers reviewed the types of bacteria that colonize human-built environments such as homes, offices, hospitals, and public transportation. They found that humans are the primary source and carrier of bacterial diversity in these spaces, and that factors like ventilation, cleaning practices, and building materials shape the microbial communities present. The study highlights the importance of understanding indoor microbial ecosystems for public health, particularly as people spend increasing amounts of time indoors.
Nanotechnology in cancer treatment: revolutionizing strategies against drug resistance
This review explores how nanotechnology is being used to overcome drug resistance in cancer treatment, using materials like carbon nanotubes, dendrimers, and liposomes to deliver drugs more precisely to tumors. While not directly about microplastics, the nanomaterial strategies discussed share relevance with understanding how nano-sized plastic particles interact with human cells and tissues.
The quest for nanoparticle-powered vaccines in cancer immunotherapy
This review explores how nanoparticles are being developed as cancer vaccine delivery systems to train the immune system to fight tumors more effectively. While focused on cancer immunotherapy rather than microplastics, the research highlights that understanding how nanoparticles interact with the immune system is crucial -- the same principles apply to understanding how nanoplastics may affect immune responses in the body.
What happens when nanoparticles encounter bacterial antibiotic resistance?
This review examines how engineered nanoparticles interact with antibiotic-resistant bacteria, a topic with significant implications for both environmental contamination and medical treatment. Researchers found that nanoparticles can either promote or inhibit antibiotic resistance depending on factors like particle size, concentration, and surface properties. The findings highlight the need for deeper understanding of how increasing nanoparticle pollution may influence the spread of antibiotic resistance genes in the environment.
Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer
Researchers examined tumor and surrounding tissue from colorectal cancer patients and found a diverse range of microplastics, including PVC and polyethylene, with tumor tissues containing a greater variety and higher distribution of microplastics than adjacent healthy tissue. A protein called clathrin that helps cells absorb materials was highly active in the cancer tissue, suggesting it may facilitate microplastic uptake and pointing to a potential link between microplastic exposure and colorectal cancer development.