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Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies
Summary
Researchers review how nanoscale materials — tiny particles engineered at the billionth-of-a-meter scale — offer a promising alternative to traditional antibiotics as bacteria develop resistance to conventional drugs. These "nanobiotics" can penetrate bacterial defenses and biofilms in ways that standard antibiotics cannot, potentially helping avert a global post-antibiotic health crisis.
Given the spasmodic increment in antimicrobial resistance (AMR), world is on the verge of "post-antibiotic era". It is anticipated that current SARS-CoV2 pandemic would worsen the situation in future, mainly due to the lack of new/next generation of antimicrobials. In this context, nanoscale materials with antimicrobial potential have a great promise to treat deadly pathogens. These functional materials are uniquely positioned to effectively interfere with the bacterial systems and augment biofilm penetration. Most importantly, the core substance, surface chemistry, shape, and size of nanomaterials define their efficacy while avoiding the development of AMR. Here, we review the mechanisms of AMR and emerging applications of nanoscale functional materials as an excellent substitute for conventional antibiotics. We discuss the potential, promises, challenges and prospects of nanobiotics to combat AMR.
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