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61,005 resultsShowing papers similar to Unraveling the in vivo fate of inhaled micro- and nanoplastics with PET imaging
ClearComparison of PET tracing and biodistribution between 64Cu-labeled micro-and nano-polystyrene in a murine inhalation model
Using advanced PET imaging in mice, researchers tracked where inhaled micro and nanoplastics traveled in the body and found that nano-sized particles cleared from the lungs much faster than micro-sized ones but accumulated more in the liver, spleen, and other organs. Micro-sized particles stayed in the lungs longer, with peak retention at 24 hours, while nano-sized particles spread quickly throughout the body. This is one of the first studies to directly visualize how inhaled plastic particles distribute through living mammals, confirming that smaller particles pose a greater risk of reaching organs beyond the lungs.
Comparison of PET tracing and biodistribution between 64Cu-labeled micro-and nano-polystyrene in a murine inhalation model
Using radioactive copper labeling and PET imaging, researchers tracked where inhaled micro- and nano-sized polystyrene particles travel in the body, finding that nanoplastics distributed more widely to organs than microplastics after lung exposure. This is significant for understanding the health risks of airborne plastic particles, which people inhale daily from synthetic textiles, dust, and urban air.
PET Tracing of Biodistribution for Orally Administered 64Cu-Labeled Polystyrene in Mice
Researchers used PET imaging to track the real-time biodistribution of orally administered radiolabeled polystyrene microplastics in mice. The study found that microplastics were absorbed from the gastrointestinal tract and distributed to various organs, providing direct visual evidence of how ingested plastic particles can travel through the body.
Harnessing PET to track micro- and nanoplastics in vivo
This study explores the use of positron emission tomography (PET) imaging to track micro- and nanoplastic particles in living organisms. Researchers developed methods to radiolabel plastic particles, enabling accurate determination of how these pollutants move through the body, which is critical for understanding the health effects of chronic microplastic exposure.
Potential Impact Microplastic Polyethylene Terephthalate on Mice
Researchers studied how polyethylene terephthalate (PET) microplastics affect mice when ingested, tracking where the particles end up in the body. They found that microplastics accumulated in various organs and caused measurable biological effects. The study adds to growing evidence that common plastic types found in food packaging may pose health risks when consumed.
Pulmonary accumulation and immune modulation by intravenously administered environmentally relevant microplastics in mice
Researchers intravenously administered environmentally relevant oxidized polyethylene microplastics to mice and tracked their distribution using fluorescent labeling. The particles primarily accumulated in the lungs and induced inflammatory cell infiltration, demonstrating that microplastics entering the bloodstream can concentrate in pulmonary tissue and trigger immune responses.
In Vivo Tissue Distribution of Microplastics and Systemic Metabolomic Alterations After Gastrointestinal Exposure
Researchers fed mice a mixture of common microplastics and then tracked where the particles ended up in the body and how they affected metabolism. They found that ingested microplastics crossed the gut barrier and accumulated in the liver, kidneys, and other tissues, causing measurable changes in metabolic pathways. The study provides evidence that microplastic exposure through the digestive system can lead to widespread tissue distribution and systemic metabolic disruption in mammals.
Biodistribution of nanoplastics in mice: advancing analytical techniques using metal-doped plastics
Researchers developed a new analytical method using palladium-doped nanoplastics to track where plastic particles go in the body after ingestion in mice. They found that after short-term exposure, most particles passed through the digestive system and were excreted, but longer-term exposure led to accumulation in body tissues. The study advances the ability to detect and trace nanoplastics at extremely small concentrations in biological samples.
Mass Balance Tracing of In Vivo Biodistribution, Relocation, and Excretion of Europium-Doped Micro/Nanoplastics in Rats
Scientists injected tiny plastic particles into rats and tracked where they went in the body for three months. Most plastic particles collected in the liver and spleen, with smaller particles being harder for the body to get rid of—only 80% of the smallest particles were eliminated compared to just 15% of larger ones. This suggests that microplastics from food, water, and air could build up in our organs over time, though the long-term health effects are still unknown.
Organ-specific accumulation and toxicity analysis of orally administered polyethylene terephthalate microplastics
When mice were fed tiny PET plastic particles (the kind found in water bottles and food containers), the particles accumulated mainly in the lungs and caused inflammatory damage at higher doses. The study found that male mice were more sensitive than females, and the results highlight that microplastics swallowed through food and drink can travel to and harm organs beyond the digestive system.
Distribution and Tissue Damage After a Single Microplastic Exposure in Mice
Researchers administered fluorescent microplastics to mice by oral gavage and tracked their distribution through the body over several hours. They found direct evidence of microplastic particles in the blood, lungs, brain, kidneys, liver, and spleen, with fluorescence peaking at two hours after exposure. Histological examination revealed mild tissue damage including congestion in the liver and lungs, providing evidence that ingested microplastics can enter the bloodstream and reach multiple organs.
Size-Dependent Pulmonary Toxicity and Whole-Body Distribution of Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure
Researchers exposed mice to airborne micro- and nanoplastic particles through normal breathing over an extended period and found the highest accumulation in the lungs, followed by the blood and spleen. Surprisingly, the larger 1-micrometer microplastics caused more severe lung damage than the smaller 80-nanometer particles, triggering inflammation, cell death, and scarring. These findings highlight that breathing in airborne plastic particles poses real health risks, with particle size playing an important role in the type of damage caused.
In Vivo Tissue Distribution of Microplastics and the Systemic Metabolic Changes After Gastrointestinal Exposure in Mice
Mice exposed to microplastics via the gastrointestinal route showed systemic distribution of particles to multiple organs and measurable changes in metabolic pathways, providing early in vivo evidence of systemic impacts from plastic ingestion.
Toxicity Study and Quantitative Evaluation of Polyethylene Microplastics in ICR Mice
Researchers fed polyethylene microplastics to mice over 28 days to study their toxicity, and used Raman spectroscopy to track where the particles ended up. They detected microplastics in the lungs, stomach, intestines, and blood serum, with repeated oral exposure leading to inflammation in lung tissue. The findings provide evidence that ingested microplastics can travel beyond the gut and accumulate in other organs.
MRI-based microplastic tracking in vivo and targeted toxicity analysis
Researchers developed a new MRI-based method to track microplastics inside living mice over 21 days. They found that the liver was the primary organ where polystyrene microplastics accumulated, and this accumulation led to liver cell death, inflammation, and changes in enzyme levels. This tracking technique could help scientists better understand how microplastics move through and affect biological systems.
A physiologically based toxicokinetic model for microplastics and nanoplastics in mice after oral exposure and its implications for human dietary exposure assessment
Researchers built the first computer model that predicts how micro- and nanoplastics distribute throughout the body after being swallowed, based on real mouse data. The model shows that particles smaller than 1 micrometer are absorbed much more efficiently from the gut and accumulate in organs like the liver and kidneys. This tool can now be used to estimate how much microplastic from food and water actually builds up in human tissues, helping to assess real health risks.
MassBalance Tracing of In Vivo Biodistribution,Relocation, and Excretion of Europium-Doped Micro/Nanoplastics inRats
This rat study used europium-labeled micro- and nanoplastics to track particle distribution in the body after intravenous administration, finding that most accumulated in the liver and spleen with very little reaching the brain or heart. The results suggest that standard biological filtration processes govern microplastic distribution following classical size-dependent rules.
Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure
Researchers fed mice polystyrene microplastics of two sizes and tracked where the particles accumulated in the body, finding them in the liver, kidneys, and gut with distribution patterns depending on particle size. Biochemical analysis revealed that microplastic exposure disrupted energy and fat metabolism, caused oxidative stress, and altered markers of neurotoxicity in the blood. The study provides evidence that microplastics can accumulate in mammalian tissues and may pose widespread health risks.
Analysis of Biodistribution and in vivo Toxicity of Varying Sized Polystyrene Micro and Nanoplastics in Mice
This study found that smaller plastic particles spread more widely through the bodies of mice and caused more organ damage than larger ones, particularly in the liver, kidneys, and heart. Nanoplastics (under 1 micrometer) were especially concerning because they crossed biological barriers more easily than microplastics. The results suggest that the tiniest plastic particles in our environment may pose the greatest health risks.
Size-Dependent PulmonaryToxicity and Whole-Body Distributionof Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure
Researchers used a whole-body inhalation exposure system to chronically expose male mice to polystyrene micro- and nanoplastics at environmental concentrations and tracked particle distribution and lung toxicity. Nanoplastics (80 nm) showed greater tissue transport than microplastics (1 µm), with highest accumulation in lungs followed by blood and spleen, and both sizes disrupted oxidative balance and antioxidant defenses.
Imaging and quantifying the biological uptake and distribution of nanoplastics using a dual-functional model material
This study used advanced imaging techniques to visualize and quantify nanoplastic uptake and distribution in biological systems, tracking particle translocation from exposure routes into tissues and characterizing intracellular localization.
The Uptake and Distribution Evidence of Nano- and Microplastics in vivo after a Single High Dose of Oral Exposure.
This in vivo study provided evidence on the uptake and organ distribution of nano- and microplastics following a single high-dose administration, finding that nanoplastics translocated rapidly to multiple organs through blood circulation while only small amounts of larger microplastics penetrated organs.
Near-infrared (NIR-II) fluorescent poly(ethylene terephthalate) nano-microplastics for in vivo tracking
Researchers developed a new method to track nano-microplastics inside living animals in real time using near-infrared fluorescent imaging. By embedding a special dye into common PET plastic particles, they were able to follow the particles through mice after oral exposure, offering a promising tool for studying how plastics of different sizes behave inside the body.
In vivo toxicity assessment of microplastics in Balb/C mice : study of inhalation exposure and its inflammatory effects
Researchers examined the in vivo toxicity of inhaled microplastics in Balb/C mice, studying pulmonary inflammation, oxidative stress, and systemic effects following repeated inhalation exposure. The study found dose-dependent lung inflammation and evidence of particle translocation to other organs.