We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Near-infrared (NIR-II) fluorescent poly(ethylene terephthalate) nano-microplastics for in vivo tracking
Summary
Researchers developed a new method to track nano-microplastics inside living animals in real time using near-infrared fluorescent imaging. By embedding a special dye into common PET plastic particles, they were able to follow the particles through mice after oral exposure, offering a promising tool for studying how plastics of different sizes behave inside the body.
Abstract Environmental health concerns because of nano-microplastics (NMPs) are growing, yet in vivo data in mammals remain scarce. Most analysis techniques rely on excised organs, limiting the ability to observe real-time NMP migration within living organisms. Therefore, there is an increasing need for simple, non-invasive techniques to track NMPs in vivo. In this study, we utilized near-infrared (NIR) fluorescence (NIRF), known as the second biological window in NIR (NIR-II), and applied it to in vivo optical imaging of deep tissue. NIR-II fluorescent poly(ethylene terephthalate) (PET) particles were synthesized by encapsulating the NIR-II fluorescent dye IR-1061 into PET. PET was dissolved in acetonitrile and stirred with IR-1061 under a nitrogen atmosphere for 24 h, with a dye loading of 1.56 mg/mg PET. To prevent agglomeration and control particle size (30–300 nm), an aqueous bovine serum albumin solution (0.02–50 mg/mL) was added. The mixture was then stirred in open air for 48 h to evaporate residual acetonitrile. In vivo NIRF imaging enabled real-time tracking of PET particles’ distribution over time following oral administration to mice. This method offers a promising platform for evaluating the behavior and potential toxicity of NMPs based on their size and composition.
Sign in to start a discussion.
More Papers Like This
NIR-II Plastic Particles for Monitoring IntestinalMotility and Microplastic Deposition in Mice
Researchers developed near-infrared II (NIR-II) fluorescent plastic particles to non-invasively track microplastic movement and deposition in living mice, finding that microplastics accumulated preferentially in the intestine with slow clearance.
Synthesis of near-infrared-fluorophore-loaded microplastics with different compositions for in vivo tracking
Researchers synthesised fluorescent microplastic particles of different polymer types that can be tracked inside living animals using near-infrared imaging, creating a tool for studying how microplastics move through and accumulate within biological tissues. These model particles help researchers understand real-world microplastic behaviour inside organisms, which is critical for assessing health risks.
Noncovalent radiolabeling of microplastics using a desferrioxamine-conjugated Nile Red derivative for quantitative in vivo tracking
Researchers developed a new method for tracking microplastics in living organisms using a specialized dye that attaches to plastic surfaces without altering their properties, enabling both fluorescence imaging and radioactive labeling. The technique allowed quantitative tracking of microplastic movement through the gastrointestinal tract of mice using PET imaging, providing a tool for better understanding how microplastics behave in the body.
NIR-II Plastic Particles for Monitoring IntestinalMotility and Microplastic Deposition in Mice
Researchers developed NIR-II fluorescent microplastic tracers to non-invasively monitor intestinal motility and microplastic deposition in living mice, enabling real-time imaging of how plastic particles travel and accumulate within the gut. (Duplicate record.)
NIR-II Plastic Particles for Monitoring IntestinalMotility and Microplastic Deposition in Mice
This study created NIR-II fluorescent plastic particles to study intestinal motility and microplastic deposition in live mice, demonstrating their utility for real-time in vivo tracking of microplastic behavior in the digestive tract. (Duplicate record.)