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MRI-based microplastic tracking in vivo and targeted toxicity analysis
Summary
Researchers developed a new MRI-based method to track microplastics inside living mice over 21 days. They found that the liver was the primary organ where polystyrene microplastics accumulated, and this accumulation led to liver cell death, inflammation, and changes in enzyme levels. This tracking technique could help scientists better understand how microplastics move through and affect biological systems.
Microplastics (MPs) as an emerging pollutant have raised significant concerns in environmental health. However, elucidating the distribution of MPs in living organisms remains challenging due to their trace residue and tough detection problems. In this study, a novel magnetic resonance imaging (MRI)-based tracking method was employed to monitor functionalized MPs biodistribution in vivo. Our results identified that the liver is the primary accumulation site of polystyrene microplastics (PS-MPs) in biological systems through continuous in vivo monitoring spanning 21 days. Biochemical tests were performed to assess the toxicological effects of functionalized MPs on the liver tissue, revealing hepatocyte death, inflammatory cell infiltration, and alterations in alkaline phosphatase levels. Notably, positively charged MPs exhibited more severe effects. A combined metabolomics-proteomics analysis further revealed that PS-MPs interfered with hepatic metabolic pathways, particularly bile secretion and ABC transporters. Overall, this study effectively assessed the distribution of functionalized MPs in vivo utilizing MRI technology, validated toxicity in targeted organ, and conducted an in-depth study on underlying biotoxicity mechanism. These findings offer crucial scientific insights into the potential impact of MPs in the actual environment on human health.
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