We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Effects of Polystyrene Nanoplastics on the Biology of Human Neural Stem Cells and Human Cerebral Organoids.
ClearMolecular effects of polystyrene nanoplastics on human neural stem cells
Researchers exposed human brain stem cells to tiny polystyrene nanoplastics and found they caused oxidative stress, DNA damage, inflammation, and cell death. These findings suggest that nanoplastics could potentially harm brain development if they reach neural tissue, though more research is needed to understand real-world exposure levels.
Internalization and toxicity of polystyrene nanoplastics on inmortalized human neural stem cells
Researchers tested 30-nanometer polystyrene particles on human neural stem cells grown in the lab and found the particles entered the cells, accumulated inside them, and triggered cell death. The nanoplastics also slowed cell growth but did not penetrate the cell nucleus. This study provides direct evidence that nanoplastics could harm the brain's stem cells, raising concerns about potential effects on brain development.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
Researchers found that maternal exposure to polystyrene nanoplastics caused brain abnormalities in offspring, demonstrating that nanoplastics can cross maternal barriers and affect neurological development in progeny with implications for developmental toxicology.
Microplastics exposure affects neural development of human pluripotent stem cell-derived cortical spheroids
Researchers used lab-grown human brain tissue models to study how polystyrene microplastics affect early brain development. Short-term exposure stimulated cell growth, but longer exposure reduced cell survival and disrupted the expression of genes critical for brain tissue formation. The findings suggest that microplastic exposure could potentially interfere with embryonic brain development in a way that depends on both particle size and concentration.
Nanoplastics exposure-induced mitochondrial dysfunction contributes to disrupted stem cell differentiation in human cerebral organoids
Using lab-grown human brain organoids (miniature brain models), researchers found that polystyrene nanoplastics damaged mitochondria (the energy-producing structures in cells), leading to increased cell death and disrupted development of brain stem cells. These findings suggest that nanoplastic exposure could interfere with how brain cells develop and function, raising concerns about the neurological effects of environmental plastic pollution on humans.
Crossing barriers – tracking micro- and nanoplastic pathways into the human brain
Researchers tracked potential pathways by which micro- and nanoplastics may enter the human brain, examining both in vitro cell models and post-mortem brain tissue. They found that human monocytes rapidly internalized polystyrene particles into endocytic vesicles and mitochondria, and detected plastic particles in brain tissue samples, providing evidence that nanoplastics may be capable of crossing brain barriers.
Polystyrene nanoplastics exposure caused defective neural tube morphogenesis through caveolae-mediated endocytosis and faulty apoptosis
This study found that polystyrene nanoplastics caused abnormal neural tube formation in early embryonic development by being taken up through a specific cellular pathway and triggering defective cell death. The findings suggest nanoplastics could potentially interfere with fetal brain development, raising serious concerns about exposure during pregnancy.
Early-life exposure to polypropylene nanoplastics induces neurodevelopmental toxicity in mice and human iPSC-derived cerebral organoids
Researchers exposed pregnant mice to polypropylene nanoplastics through inhalation and found that their offspring showed impaired brain development, poor spatial memory, reduced motor coordination, and increased anxiety. Tests using human brain organoids (lab-grown mini-brains) confirmed that nanoplastics disrupt the growth and differentiation of neurons, raising concerns about fetal brain health from plastic pollution during pregnancy.
[Effects of nanopolystyrene nanoplastic exposure on the development and neurotoxicity of fetal rats during gestation].
Researchers found that gestational exposure to polystyrene nanoplastics in rats caused dose-dependent reductions in fetal body weight, body length, and brain development, with smaller 25 nm particles producing more pronounced neurotoxic effects than 50 nm particles.
PLASTAMINATION: Outcomes on the Central Nervous System and Reproduction.
This review assessed evidence for neurotoxic and reproductive effects of both biodegradable and conventional micro- and nanoplastics, finding that plastic particles and their chemical additives can cross the blood-brain barrier and disrupt hormone systems, with concerning implications for nervous system and reproductive health.
Cytotoxicity of amine-modified polystyrene MPs and NPs on neural stem cells cultured from mouse subventricular zone
Researchers tested the effects of polystyrene microplastics and nanoplastics with a positive surface charge on neural stem cells from mouse brains. Both sizes of particles reduced cell survival, but nanoplastics were significantly more toxic at lower concentrations, causing cell death and preventing stem cells from developing into mature brain cells. These findings suggest that nanoplastics that reach the brain could potentially harm the nervous system's ability to repair and maintain itself.
Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny
When pregnant mice were exposed to polystyrene nanoplastics, their offspring showed abnormal brain development including changes in neural stem cell function, altered brain structure, and cognitive problems. The effects were gender-specific, with some deficits appearing more strongly in one sex. This study raises concerns that nanoplastic exposure during pregnancy could increase the risk of neurodevelopmental problems in children.
Toxic effects and mechanisms of nanoplastics on embryonic brain development using brain organoids model
Using lab-grown brain organoids (miniature brain models), researchers found that nanoplastics exposure damaged developing brain cells, reduced the number of neural precursor cells, and disrupted connections between neurons. The damage appeared to work through the Wnt signaling pathway, which is critical for normal brain development. These findings raise concerns that nanoplastic exposure during pregnancy could potentially harm fetal brain development.
Effects of nanoplastic exposure during pregnancy and lactation on neurodevelopment of rat offspring
When pregnant and nursing rats were exposed to polystyrene nanoplastics, their offspring showed thinner brain cortexes, disrupted neurotransmitter levels, damaged connections between brain cells, and problems with anxiety and spatial memory. This study suggests that maternal exposure to nanoplastics during pregnancy and breastfeeding could affect brain development in offspring.
Polystyrene nanoplastics exposure caused defective neural tube morphogenesis through caveolae-mediated endocytosis and faulty apoptosis
Researchers found that polystyrene nanoplastics caused defective neural tube development in embryos through disruption of normal cell death processes and caveolae-mediated cellular uptake. The study suggests that nanoplastics, which can cross the placental barrier, may pose risks to fetal development by interfering with critical early-stage neurological formation.
Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring
Researchers exposed pregnant mice to polystyrene nanoplastics and studied the effects on their offspring's brain development. The study found that maternal nanoplastic exposure affected developmental milestones and brain structure in the young mice. The findings suggest that nanoplastic exposure during pregnancy may pose risks to fetal brain development, though more research is needed to understand the implications for humans.
Neurotoxicityof Micro- and Nanoplastics: A ComprehensiveReview of Central Nervous System Impacts
This comprehensive review examines neurotoxicity of micro- and nanoplastics, synthesizing evidence that MNP exposure disrupts neural signaling, promotes neuroinflammation, crosses the blood-brain barrier, and may contribute to neurodegenerative and neurodevelopmental disorders.
Potential threats of nanoplastic accumulation in human induced pluripotent stem cells
Researchers found that polystyrene nanoplastics accumulated in human induced pluripotent stem cells over long-term exposure, causing subtle changes in cell differentiation and raising concerns about nanoplastic threats to human developmental biology.
Micro-nanoplastics in the central nervous system: Evidence, mechanisms and perspectives
This review examines evidence that micro- and nanoplastics can cross the blood-brain barrier and cause neurotoxicity through oxidative stress, neuroinflammation, and disruption of neurotransmitter signaling. While clinical studies have confirmed the presence of plastic particles in human brain tissue and cerebrospinal fluid, the authors note that methodological limitations and inconsistent quality controls currently prevent establishing a definitive causal link to neurological conditions.
Insights into the toxic effects of micro-nano-plastics on the human brain and their relationship with the onset of neurological diseases: A narrative review.
This review examined toxic effects of micro and nano-plastics (MNPs) on the human brain, linking MNP exposure to neuroinflammation, oxidative stress, disruption of the blood-brain barrier, and progression toward neurodegenerative diseases. The authors synthesized evidence from cell studies, animal models, and emerging human data.
The potential toxicity of polystyrene nanoplastics to human trophoblasts in vitro
Researchers used human trophoblast cells to evaluate the potential toxicity of 100-nanometer polystyrene nanoplastics on placental function. The study found that nanoplastic exposure affected trophoblast cell viability and function at certain concentrations, suggesting potential implications for understanding nanoplastic effects during pregnancy.
Polystyrene Micro- and Nanoplastic Exposure Triggers an Activation and Stress Response in Human Astrocytes
Researchers exposed primary human astrocytes to polystyrene micro- and nanoplastics and found that these particles triggered cellular stress responses, including increased production of reactive oxygen species and activation of inflammatory pathways. Nanoplastics were particularly effective at penetrating cells and disrupting normal astrocyte function. The findings suggest that plastic particle exposure may contribute to neuroinflammatory processes in the brain, warranting further investigation into potential neurotoxic effects.
Microplastics/nanoplastics and neurological health: An overview of neurological defects and mechanisms
This review summarizes evidence that micro and nanoplastics can harm the nervous system, causing developmental abnormalities, brain cell death, neurological inflammation, and potentially contributing to neurodegenerative diseases. Animal studies show that these tiny plastics can cross the blood-brain barrier and accumulate in brain tissue, where they trigger oxidative stress and disrupt normal brain function. While direct evidence in humans is still limited, the findings suggest that chronic microplastic exposure could be a risk factor for neurological health problems.
Polystyrene nanoplastics exposure caused defective neural tube morphogenesis through caveolae-mediated endocytosis and faulty apoptosis
This study found that polystyrene nanoplastics caused abnormal neural tube formation during early embryonic development by disrupting normal apoptosis. The findings raise concerns about nanoplastic exposure during fetal development, as nanoplastics are small enough to cross the placental barrier.