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Potential threats of nanoplastic accumulation in human induced pluripotent stem cells
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Researchers found that polystyrene nanoplastics accumulated in human induced pluripotent stem cells over long-term exposure, causing subtle changes in cell differentiation and raising concerns about nanoplastic threats to human developmental biology.
The threat to humans from nanoplastics (NPs) is increasing invisibly. Nowadays, many people are concerned about human safety and health, but few are reported about the effects of NP on humans. To overcome the limitations in human studies, human induced pluripotent stem cells (hiPSCs) were used as an optimal platform to investigate toxicity and subtle changes in differentiation caused by intracellular NPs accumulation for a long-term. Negatively charged polystyrene nanoplastics (PS NPs) were used to exclude acute toxic issues of surface charge and investigate the impact of the NP's size and nature during bioaccumulation. Intracellular observations revealed that excessive amounts of NPs were internalized into single cells and colonies within 48 h. Substantial growth inhibition and a slight reduction in self renewal capacity of hiPSCs occurred with respect to internalized NPs. Unexpectedly, the accumulated NPs in hiPSC did not exhibit chronic toxicity or adversely affect differentiation for 14 days.
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Potential Threats of Nanoplastic Accumulation in Human Induced Pluripotent Stem Cells
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Researchers investigated whether nanoplastics accumulate in human induced pluripotent stem cells (iPSCs)—cells that can develop into any tissue type—finding that nanoplastics entered the cells and affected their behavior. This raises concern that nanoplastic exposure could potentially disrupt tissue development and regeneration.
Polystyrene nanoplastics affect transcriptomic and epigenomic signatures of human fibroblasts and derived induced pluripotent stem cells: Implications for human health
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Researchers found that polystyrene nanoplastics altered transcriptomic and epigenomic signatures in human fibroblasts and derived induced pluripotent stem cells, demonstrating that plastic particle exposure can cause lasting molecular changes with potential implications for human health.
Molecular effects of polystyrene nanoplastics on human neural stem cells
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Researchers exposed human brain stem cells to tiny polystyrene nanoplastics and found they caused oxidative stress, DNA damage, inflammation, and cell death. These findings suggest that nanoplastics could potentially harm brain development if they reach neural tissue, though more research is needed to understand real-world exposure levels.
Developmental toxicity of microplastics in human stem cells using adverse outcome pathway based integrated approaches to testing and assessment approach
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Researchers applied an Integrated Approaches to Testing and Assessment framework to evaluate the developmental toxicity of polystyrene micro- and nanoplastics using human embryonic stem cells. They found that stem cells took up the plastic particles and showed size-dependent cytotoxicity and effects on germ layer differentiation. The study provides a structured, non-animal testing framework for assessing developmental risks from emerging contaminants like micro- and nanoplastics.
Internalization and toxicity of polystyrene nanoplastics on inmortalized human neural stem cells
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Researchers tested 30-nanometer polystyrene particles on human neural stem cells grown in the lab and found the particles entered the cells, accumulated inside them, and triggered cell death. The nanoplastics also slowed cell growth but did not penetrate the cell nucleus. This study provides direct evidence that nanoplastics could harm the brain's stem cells, raising concerns about potential effects on brain development.
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