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Article Tier 2 Human Health Effects Nanoplastics Reproductive & Development Sign in to save

Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring

Environmental Science Advances 2023 41 citations

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Researchers exposed pregnant mice to polystyrene nanoplastics and studied the effects on their offspring's brain development. The study found that maternal nanoplastic exposure affected developmental milestones and brain structure in the young mice. The findings suggest that nanoplastic exposure during pregnancy may pose risks to fetal brain development, though more research is needed to understand the implications for humans.

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Maternal exposure to polystyrene nanoplastics impact postnatal brain development in mouse offspring. This work motivates further studies to determine the levels of nanoplastics in the environment.

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Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny

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When pregnant mice were exposed to polystyrene nanoplastics, their offspring showed abnormal brain development including changes in neural stem cell function, altered brain structure, and cognitive problems. The effects were gender-specific, with some deficits appearing more strongly in one sex. This study raises concerns that nanoplastic exposure during pregnancy could increase the risk of neurodevelopmental problems in children.

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Maternal exposure to polystyrene nanoplastics causes brain abnormalities in progeny

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Researchers found that maternal exposure to polystyrene nanoplastics caused brain abnormalities in offspring, demonstrating that nanoplastics can cross maternal barriers and affect neurological development in progeny with implications for developmental toxicology.

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Teratological, neurochemical and histomorphic changes in the limbic areas of F1 mice progeny due to co-parental polystyrene nanoplastic exposure

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Researchers exposed parent mice to polystyrene nanoplastics before and during pregnancy and found that offspring exhibited skeletal and visceral malformations, impaired neonatal reflexes, learning deficits, and structural brain changes — including reduced hippocampal neurons — demonstrating transgenerational neurodevelopmental harm from nanoplastic exposure.

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Effects of nanoplastic exposure during pregnancy and lactation on neurodevelopment of rat offspring

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When pregnant and nursing rats were exposed to polystyrene nanoplastics, their offspring showed thinner brain cortexes, disrupted neurotransmitter levels, damaged connections between brain cells, and problems with anxiety and spatial memory. This study suggests that maternal exposure to nanoplastics during pregnancy and breastfeeding could affect brain development in offspring.

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Postnatal development outcomes in mice after gestational exposure to polystyrene nanoplastics

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Researchers exposed pregnant mice to low-dose polystyrene nanoplastics and found offspring developmental abnormalities including altered anogenital distance, delayed reflexes, and reduced brain and kidney weights in males by postnatal day 42, suggesting even modest gestational exposures may perturb early development and reproductive system maturation.

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