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Papers
61,005 resultsShowing papers similar to Immunotherapeutic strategy in the management of gastric cancer: molecular profiles, current practice, and ongoing trials
ClearMeta-analysis of H. pylori and the gut microbiome interactions and clinical outcomes
This meta-analysis identified specific gut microbial signatures associated with H. pylori infection and disease progression, offering predictive models for early diagnosis and risk stratification. The findings support microbiome-based approaches to personalized treatment of H. pylori-associated gastrointestinal disorders.
Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features
Researchers detected and characterized microplastics in human gastric cancer tissue and adjacent healthy tissue, finding significantly higher microplastic concentrations in cancer tissue, and used transcriptome sequencing to explore potential molecular mechanisms linking microplastic exposure to gastric cancer development.
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma
Researchers found that a protein called SLC7A11, stabilized by the cancer-driving protein EGFR, blocks cancer cells from being recognized and destroyed by the immune system in nasopharyngeal carcinoma, and showed that the drug sorafenib can reverse this immune evasion by targeting SLC7A11.
Contributing factors common to COVID‑19 and gastrointestinal cancer
This review identifies contributing factors common to COVID-19 vulnerability and gastrointestinal cancer risk, including gut microbiome dysbiosis, dietary patterns, and chronic inflammation, suggesting that immune dysfunction driven by environmental and lifestyle factors underlies susceptibility to both conditions.
Correlation Between Tumor Differentiation and Biomarkers in Hepatocellular Carcinoma: Implications for Early Diagnosis and Treatment
Researchers examined the correlation between tumor differentiation levels and biomarker expression in patients with hepatocellular carcinoma. The study found significant associations between tumor grade and certain biomarker levels, suggesting these markers may have potential value for early diagnosis and treatment planning in liver cancer.
Cisplatin promotes pyroptosis of gastric cancer cells by activating GSDME
This paper is not about microplastics; it investigates how the chemotherapy drug cisplatin kills gastric cancer cells via a cell death pathway called pyroptosis, identifying the GSDME gene as a key mediator and independent prognostic marker in gastric cancer patients.
Maltol has anti-cancer effects via modulating PD-L1 signaling pathway in B16F10 cells
Researchers found that maltol, a natural compound with antioxidant and anti-inflammatory properties, showed anti-melanoma activity by suppressing the PD-L1 immune checkpoint signaling pathway in mouse skin cancer cells. The compound enhanced the effectiveness of cisplatin chemotherapy and increased immune cell-mediated destruction of cancer cells. The study suggests that maltol may have potential as a complementary agent in melanoma immunotherapy approaches.
Endoplasmic Reticulum Stress-Related Signature for Predicting Prognosis and Immune Features in Hepatocellular Carcinoma
Researchers developed a four-gene endoplasmic reticulum stress-based prognostic model for hepatocellular carcinoma using bioinformatics approaches, finding that higher risk scores correlated with advanced tumor stage, HBV infection, and worse survival outcomes. The model also predicted differences in immune cell infiltration profiles, suggesting potential utility for guiding immunotherapy decisions.
Building an ensemble learning model for gastric cancer cell line classification via rapid raman spectroscopy
Researchers developed an ensemble learning model using rapid Raman spectroscopy to classify gastric cancer cell lines without staining or culturing, achieving high accuracy for automated cell line identification.
Tanshinone IIA May Inhibit Gastric Cancer via Affecting the Intestinal Microbiome
Researchers investigated whether tanshinone IIA, a compound derived from Salvia miltiorrhiza, inhibits gastric cancer tumor growth through modulation of the intestinal microbiome and regulation of NF-kB signaling. The study found that tanshinone IIA altered the gut microbial composition and suppressed NF-kB pathway activity, suggesting a microbiome-mediated mechanism underlying its anti-tumor effects.
Identification and validation of novel signature associated with hepatocellular carcinoma prognosis using Single-cell and WGCNA analysis
This study identified a novel gene signature associated with hepatocellular carcinoma using TCGA datasets and validated key molecular targets with potential prognostic and therapeutic significance. The findings advance understanding of the molecular mechanisms driving liver cancer progression.
Autoimmune Diseases of the GI Tract Part I: Etiology and Pathophysiology
This review examines the etiology and pathophysiology of the five most common autoimmune diseases of the gastrointestinal tract, exploring the interplay of genetic susceptibility, environmental triggers, and gut-brain axis dysfunction in driving the post-World War II pandemic rise in autoimmune conditions.
Endoplasmic Reticulum Stress-related Classification for Prognosis Prediction in Hepatocellular Carcinoma
Researchers used gene expression data to create an endoplasmic reticulum stress-based classification system for predicting outcomes in liver cancer patients. The model identified patient subgroups with significantly different survival rates.
Intratumoural microbiota: from theory to clinical application
Researchers reviewed how bacteria living inside tumors — called intratumoural microbiota — influence cancer development, immune responses, and treatment outcomes. They highlight that while some tumor-resident microbes drive cancer progression by damaging DNA and disrupting immune signaling, engineered bacteria could be harnessed as novel therapeutic tools to target tumors directly.
Gastroprotective Effects of Periplaneta americana L. Extract Against Ethanol-Induced Gastric Ulcer in Mice by Suppressing Apoptosis-Related Pathways
Researchers examined the gastroprotective effects of Periplaneta americana extract against ethanol-induced gastric ulcers in mice, finding that the extract suppressed apoptosis-related pathways and protected gastric tissue from programmed cell death.
Role of dietary nutrients and metabolism in colorectal cancer.
This review examines how dietary nutrients including glucose, amino acids, lipids, vitamins, and prebiotics may influence colorectal cancer risk and progression. The study discusses metabolic interactions between tumor cells, the tumor microenvironment, and gut microbiota, suggesting that nutritional factors play a meaningful role in shaping these complex biological processes.
Multiple primary lung cancer: Updates of clinical management and genomic features
This review summarizes recent advances in the diagnosis and treatment of multiple primary lung cancer, a condition that is increasingly common in clinical practice. The study discusses how next-generation sequencing has improved the ability to distinguish multiple primary tumors from metastatic disease, and how non-operative therapies like ablation and stereotactic radiotherapy are becoming more prevalent treatment options.
Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma
This review examines biomarkers used for diagnosing and predicting treatment responses in allergic diseases and asthma, focusing on advances in personalized medicine. Researchers discuss how molecular and cellular markers can help classify disease subtypes and guide targeted therapies. The study highlights the shift toward precision medicine approaches that tailor treatments to individual patient profiles rather than using one-size-fits-all strategies.
Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review
This review examined the lipidome as a regulator of lipid metabolism in the gastrointestinal tract and proposed that lipid-protein interactions and lipoprotein transport pathways may play a protective role during COVID-19, with implications for understanding disease severity in metabolically vulnerable individuals.
Immune mechanism of gut microbiota and its metabolites in the occurrence and development of cardiovascular diseases
This review examines immune mechanisms linking gut microbiota and its metabolites to cardiovascular diseases, explaining how disruptions in the microbiota-immune balance contribute to conditions such as atherosclerosis, hypertension, and heart failure.
Tumour-associated macrophages: versatile players in the tumour microenvironment
This review explores tumour-associated macrophages, immune cells that play complex and sometimes contradictory roles in cancer, both helping tumours grow and fighting them. Researchers describe newly discovered behaviors of these cells, including their ability to transform into other cell types. The study highlights the potential of targeting these macrophages as a strategy in cancer immunotherapy.
Microplastic in Gastric Fasting Liquid and Associated Gastric Pathology
This study found microplastic particles in gastric fluid samples collected from patients undergoing routine stomach examinations, and noted associations between microplastic presence and gastric pathologies including H. pylori infection, intestinal metaplasia, and inflammation. The findings provide direct clinical evidence that microplastics accumulate in the human stomach and may be linked to gastric disease, though causality is not yet established. This is an important step toward understanding whether microplastic ingestion contributes to gastrointestinal health problems in humans.
Interaction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers examined whether polystyrene nanoplastics and Helicobacter pylori bacteria can jointly enter gastric cancer cells and influence cancer progression. The study found that combined exposure to nanoplastics and H. pylori modulated cell proliferation, apoptosis, autophagy, and metastasis in gastric cancer cells, suggesting that nanoplastic contamination may interact with bacterial infections to affect cancer-related cellular processes.
Interaction of Polystyrene Nanoplastics and Helicobacter pylori Modulates Gastric Cancer Cellular Functions and Metastasis
Researchers examined whether polystyrene nanoplastics and Helicobacter pylori bacteria can jointly enter gastric cancer cells and influence cancer progression. The study found that combined exposure to nanoplastics and H. pylori modulated cell proliferation, apoptosis, autophagy, and metastasis in gastric cancer cells, suggesting that nanoplastic contamination may interact with bacterial infections to affect cancer-related cellular processes.