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61,005 resultsShowing papers similar to Intermittent Fasting as New Approaches as Anti Aging for Preventing Age-associated Diseases
ClearNeurosenescence, inflammaging and neuroinflammation in neurodegenerative disorders
This review paper summarizes existing research showing that as we age, our brain cells and immune system deteriorate in ways that may contribute to diseases like Alzheimer's and Parkinson's. The aging process causes harmful inflammation in the brain, and scientists have identified specific biological markers that signal this damage is happening. Understanding these aging patterns could help researchers develop new treatments called "senolytic therapies" that target and remove damaged aging cells to potentially slow or prevent brain diseases.
Intermittent fasting protects against food allergy in a murine model via regulating gut microbiota
In a mouse model of food allergy, long-term intermittent fasting attenuated allergic responses by reducing Th2 inflammation, maintaining intestinal barrier integrity, and preventing gut microbiota dysbiosis.
Nanoplastics: An emerging environmental concern in age-related diseases
This review examines the growing body of evidence linking nanoplastics to aging and age-related conditions. Researchers found that nanoplastics can disrupt key molecular pathways involved in inflammation, oxidative stress, and cellular damage that are central to the aging process. The study suggests that chronic nanoplastic exposure may accelerate biological aging, raising concerns about long-term health effects as environmental plastic pollution continues to increase.
Micro/nanoplastic-driven cardiovascular senescence and multi-target intervention by traditional Chinese medicine
Researchers reviewed how micro- and nanoplastics accumulate in cardiovascular tissues and accelerate cellular aging through mitochondrial damage, epigenetic changes, telomere shortening, and chronic inflammation, while also highlighting traditional Chinese medicine's multi-target compounds as a potential countermeasure by simultaneously addressing oxidative stress, fibrosis, and cell death pathways.
Microplastics/nanoplastics contribute to aging and age-related diseases: Mitochondrial dysfunction as a crucial role
This review examines how microplastics and nanoplastics may contribute to aging and age-related conditions by damaging mitochondria, the energy-producing structures inside cells. Researchers describe how these tiny plastic particles enter the body through food, water, and air, and accumulate in various organs where they can disrupt normal mitochondrial function. The study suggests that microplastic-driven mitochondrial damage could be an underappreciated factor in the aging process and related health decline.
Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases
Researchers reviewed how mitochondria — the cell's energy factories — communicate both within and between cells, and how this communication breaks down as we age. When mitochondrial function and signaling both fail together, it creates a damaging cycle that drives age-related diseases, but targeting these pathways may offer new ways to extend healthy lifespan.
The role of ageing and oxidative stress in intervertebral disc degeneration
This review details how aging and oxidative stress synergistically drive intervertebral disc degeneration through mitochondrial dysfunction, increased reactive oxygen species, and decreased antioxidant capacity. The progressive breakdown of disc matrix components under chronic oxidative damage suggests antioxidant therapies could potentially slow disc degeneration.
Preventing ovarian aging: from redox-targeted strategies to extracellular vesicle-based therapies
This review paper summarizes research showing that ovarian aging (when a woman's ovaries stop working properly) can be sped up by things like smoking, unhealthy diets, chemicals in plastics, and tiny plastic particles we're exposed to every day. Scientists are studying treatments like antioxidants and special cell therapies that might help protect women's ovaries from this damage. This matters because healthier ovaries could help women maintain their fertility longer and reduce health problems related to hormone changes as they age.
Epigenetic Effects of Healthy Foods and Lifestyle Habits from the Southern European Atlantic Diet Pattern: A Narrative Review
Researchers reviewed how the Southern European Atlantic diet — rich in fish, vegetables, and minimally processed foods — influences epigenetic markers such as DNA methylation and microRNA expression, proposing that this dietary pattern promotes healthy aging by modulating gene expression through nutrient-driven epigenetic mechanisms.
Redox regulation in aging muscles: exercise as a key modulator to combat sarcopenia and frailty
Researchers reviewed evidence on how aerobic and resistance exercise modulates redox homeostasis in aging skeletal muscle, synthesizing findings from randomized controlled trials and meta-analyses to show that exercise reduces oxidative stress markers by 10–20%, enhances antioxidant enzyme activity by 15–30%, and improves muscle strength and frailty scores through pathways including Nrf2, AMPK, and PGC-1α activation.
Gut microbiota: an ideal biomarker and intervention strategy for aging
Not relevant to microplastics — this review explores how gut microbiome composition can serve as a biomarker for aging and a target for anti-aging interventions in humans, without addressing plastic pollution.
Drosophila as a Robust Model System for Assessing Autophagy: A Review
This review explores how the fruit fly Drosophila melanogaster serves as a powerful research model for studying autophagy, the cellular recycling process that plays roles in aging, immune response, and disease. Researchers describe the genetic tools and techniques available in Drosophila that allow detailed investigation of autophagy mechanisms in a living organism. The study highlights that insights from fruit fly research continue to advance our understanding of how autophagy functions in more complex organisms, including humans.
Cognitive and functional resilience as markers of longevity and successful ageing
This systematic literature review examined cognitive and functional resilience as markers of longevity and successful aging, synthesizing evidence on how these capacities are influenced by genetics, environment, and lifestyle and can predict quality of life in older adults.
A Comprehensive Review of Pathological Mechanisms and Natural Dietary Ingredients for the Management and Prevention of Sarcopenia
This review explores natural dietary ingredients, including plant extracts, phytochemicals, and probiotics, that may help prevent or manage sarcopenia, the age-related loss of muscle mass and strength. Researchers found that certain compounds can influence muscle protein synthesis, reduce inflammation, and support gut health in ways that benefit muscle maintenance. The study highlights how diet-based approaches could complement exercise in preserving muscle function as people age.
СЛЕД МИКРОПЛАСТИКА В ГЕРОНТОЛОГИИ: МЕТААНАЛИЗ ЕГО РОЛИ В МОДУЛЯЦИИ ДОЛГОЛЕТИЯ
This meta-analysis of 33 studies examined how microplastics may affect aging and longevity. It found that microplastic exposure was linked to increased oxidative stress, inflammation, and cellular aging markers, suggesting that long-term microplastic accumulation in the body could potentially accelerate the aging process.
Signs of Alzheimer’s Disease: Tied to Aging
This review explores the core biological mechanisms that connect aging to Alzheimer's disease, including abnormal protein buildup, chronic brain inflammation, loss of key neurotransmitters, and blood-brain barrier dysfunction. Researchers highlight how age-related decline in the body's ability to clear waste and repair cellular damage accelerates the progression of neurodegeneration. The study underscores the need for treatments that target multiple pathways simultaneously rather than addressing a single mechanism.
Polystyrene nanoplastics induce ovarian granulosa cell senescence via autophagy suppression
Researchers found that polystyrene nanoplastics induce premature cellular aging (senescence) in human ovarian granulosa cells by suppressing autophagy, triggering inflammatory signaling and mitochondrial dysfunction, and that restoring autophagy with rapamycin reversed these effects — pointing to a potential mechanism linking nanoplastic exposure to accelerated ovarian aging.
Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia
This review summarized how mTOR signaling regulates skeletal muscle maintenance and how dysregulation contributes to sarcopenia, the age-related loss of muscle mass and function. Intervention strategies targeting mTOR including exercise, caloric restriction, and plant extract supplementation show promise for slowing muscle decline in aging.
Biological Aging Acceleration Due to Environmental Exposures: An Exciting New Direction in Toxicogenomics Research
This review explores how environmental exposures, including pollutants and lifestyle factors, can accelerate biological aging at the molecular level. Researchers examine biological clock technologies that measure changes in DNA and other cellular markers to assess aging acceleration. The study highlights emerging evidence that toxic exposures may speed up aging processes, offering a new way to evaluate the long-term health impacts of environmental contaminants.
Micro- and Nanoplastics Exposure Across the Lifespan: One Health Implications for Aging and Longevity
Researchers reviewed evidence on micro- and nanoplastic exposure across the human lifespan through a One Health lens, finding that MNPs trigger oxidative stress, inflammation, mitochondrial dysfunction, and cellular senescence—mechanisms central to aging—and that older adults face compounded risk from lifetime accumulation and diminished physiological resilience, though direct epidemiological data in this population remain sparse.
Aging, longevity, and the role of environmental stressors: a focus on wildfire smoke and air quality
This review explores how environmental stressors, particularly wildfire smoke, interact with the biological mechanisms of aging, including telomere attrition, cellular senescence, and mitochondrial dysfunction. Preliminary evidence suggests that inhaled wildfire smoke toxicants may accelerate neurological aging markers and compromise blood-brain barrier integrity, though the intersection between environmental exposures and aging processes remains under-studied.
Causality of Aging Hallmarks
This article argues that among the twelve recognized hallmarks of aging, telomere shortening is the primary causal driver, proposing that co-regulation of telomere and ribosomal DNA lengths via the P53 pathway mediates all other aging hallmarks, with implications for longevity research strategies.
Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease
Researchers reviewed natural bioactive compounds from plant sources for their potential neuroprotective effects related to Alzheimer's disease. The study highlights how these compounds may modulate molecular mechanisms involved in disease development, while noting challenges such as limited bioavailability and blood-brain barrier permeability.
Opportunities and Challenges for Nanotherapeutics for the Aging Population
This review explores how nanotherapeutics could address age-related changes in drug pharmacokinetics that impair efficacy and increase toxicity in elderly patients, while noting the need to balance benefits against the long-term safety of nanomaterials.