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61,005 resultsShowing papers similar to Exposomics as a discovery engine for emerging contaminants and hidden biological risks
ClearExposomics as a discovery engine: a systematic scoping review of emerging environmental contaminants and novel biological effects
This scoping review mapped how exposomics tools—including high-resolution mass spectrometry, multi-omics integration, and wearable sensors—have been applied over the past decade to discover novel environmental contaminant exposures and their health effects. It found emerging contaminants like microplastics and PFAS increasingly captured by non-targeted approaches.
Analytical challenges in human exposome analysis with focus on environmental analysis combined with metabolomics
This review examined the analytical challenges of characterizing the human chemical exposome, covering sampling, sample preparation, and compound identification hurdles that currently limit our ability to link specific environmental chemical exposures to chronic disease outcomes.
The exposome paradigm to predict environmental health in terms of systemic homeostasis and resource balance based on NMR data science
This paper proposes an exposome framework for predicting environmental health based on systemic homeostasis, integrating data from microbial ecosystems, chemical exposures, and recycled resources to evaluate environmental illness. The approach aims to model how combined exposures disrupt biological balance in organisms and ecosystems.
The fetal exposome and preterm birth: a systematic synthesis of environmental exposures and multi-omics evidence
This systematic review integrates fetal exposome concepts with multi-omics data on preterm birth risk, concluding that combining exposure measurement with biomarker discovery may support precision-guided prenatal interventions, though standardized methodologies and equitable implementation remain challenges.
A review of the applications and challenges of applying partial least squares (PLS) to exposomics research.
This review evaluated partial least squares (PLS) regression as a statistical tool for exposomics research, where the goal is to link complex environmental exposure mixtures to health outcomes. The authors identified key analytical advantages of PLS for high-dimensional data but noted that its full potential in exposome science remains unrealized due to methodological gaps.
Perspectives on the Use of Toxicogenomics to Assess Environmental Risk
This review discussed the application of toxicogenomics, including transcriptomics, proteomics, and metabolomics, to assess environmental risk from toxic substances. The authors argued that molecular profiling technologies could improve sensitivity and mechanistic understanding of pollutant effects compared to traditional endpoint toxicity tests.
A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics
This review examines how environmental chemicals, including contaminants associated with plastics, can disrupt human metabolism and contribute to conditions like obesity and diabetes. Researchers mapped the connections between chemical exposure and changes in metabolic biomarkers that signal disease risk. The study highlights the emerging field of metabolism-disrupting chemicals and the importance of understanding how everyday environmental exposures influence long-term metabolic health.
Environmental Chemicals: Integrative Approach to Human Biomonitoring and Health Effects
This review presents an integrative framework for human biomonitoring of environmental chemicals — including microplastics, heavy metals, and endocrine disruptors — linking population-level exposure data with health outcomes to inform policy decisions on chemical risk management.
Multi-omics approaches for remediation of bisphenol A: Toxicity, risk analysis, road blocks and research perspectives
This review used multi-omics approaches to assess the toxicity of bisphenol A and its pathways for environmental remediation, integrating genomics, transcriptomics, and metabolomics data. The authors identified microbial and biochemical strategies with potential for BPA removal from contaminated environments while clarifying risk to human and ecosystem health.
Exploring the Exposome Spectrum: Unveiling Endogenous and Exogenous Factors in Non-Communicable Chronic Diseases
This review explores the concept of the exposome -- the total of all environmental exposures a person encounters throughout their lifetime, including chemical pollutants, microplastics, air pollution, and stress. It highlights how these combined exposures interact to drive chronic diseases like cancer, heart disease, and diabetes, emphasizing that microplastics are one piece of a larger puzzle of environmental health threats.
Advanced chromatographic techniques for assessing human-relevant exposure pathways to micro- and nanoplastics
This review integrates advanced chromatographic techniques for detecting micro- and nanoplastics with human-relevant exposure pathways including air, water, food, cosmetics, and human tissues, providing a comprehensive analytical framework for assessing health-relevant MNP exposure.
Chemical Fingerprinting: Advances in Analytical Techniques for Environmental Monitoring
This review examines advances in chemical fingerprinting techniques, including mass spectrometry and NMR spectroscopy, for identifying and tracking pollutants in the environment. Researchers discuss how these analytical methods can be applied to monitor complex chemical mixtures including microplastics across environmental media. The study suggests that improved fingerprinting approaches could enhance our ability to trace pollution sources and assess ecological risks.
Environmental Applications of Mass Spectrometry for Emerging Contaminants
This review covers how mass spectrometry, a powerful analytical technique, is being used to detect and measure emerging contaminants including microplastics and nanoplastics in the environment. Advances in this technology are enabling researchers to identify smaller plastic particles and trace the chemical additives they carry, which is critical for understanding human exposure risks.
Metabolomics Approach in Environmental Studies: Methodologies, Application and Challenges
This review examines how metabolomics, the study of small molecules in biological systems, is being applied to environmental research to understand how chemical pollutants including microplastics affect organism metabolism. The study highlights metabolomics as a valuable tool for assessing the biological effects of environmental exposures at the molecular level, helping researchers identify biomarkers of pollutant exposure in both wildlife and humans.
Study on toxicity effects of environmental pollutants based on metabolomics: A review
This review examines how metabolomics, a technology that measures changes in small molecules within organisms, is being used to study the toxic effects of environmental pollutants including microplastics, heavy metals, and pesticides. Researchers found that metabolomics can reveal subtle biological changes caused by pollutant exposure that traditional methods might miss. The study highlights metabolomics as a powerful tool for understanding how environmental contaminants disrupt normal biological processes at the molecular level.
Microplastics as an emerging threat to human health: Challenges and advancements in their detection
This review examined microplastics as an emerging threat to human health, highlighting their endocrine-disrupting properties, ability to accumulate pollutants, and the analytical challenges in accurately detecting and characterizing them across environmental and biological samples.
Development of High-throughput Analytical Platforms Based on Chromatographic Techniques Coupled with Mass Spectrometry for the Identification And/or Quantification of Organic Micropollutants And/or Metabolites in Environmental, Food and Clinical Matrices
This doctoral research developed high-throughput analytical methods using chromatography coupled with mass spectrometry to detect organic micropollutants including microplastics, pharmaceuticals, and PFAS in environmental, food, and clinical samples. Researchers optimized sustainable extraction and analysis protocols aligned with green analytical chemistry principles. The work advances the ability to monitor emerging contaminants and their transformation products across multiple types of sample matrices.
Integrative Biochemical Diagnostics: From Prenatal Genomics to Environmental and Behavioral Biomarkers
This short review proposes an integrative diagnostic framework linking advances in prenatal genomics, metabolic biomarkers, and environmental sensing, including detection of microplastics and endocrine-disrupting chemicals as emerging biomarkers of health risk.
Into the Multiverse: Analysis of microplastic leachates using comprehensive multi-dimensional gas chromatography-mass spectrometry
Researchers applied comprehensive multidimensional chromatography to identify the full range of chemical leachates released by plastics and microplastics in marine environments. The multi-technique approach revealed a far larger diversity of leaching compounds than targeted analyses alone would detect.
Mass spectrometry-based multimodal approaches for the identification and quantification analysis of microplastics in food matrix
This review examines mass spectrometry techniques for identifying and measuring microplastics in food, covering methods that analyze both the chemical composition and quantity of plastic particles. The study suggests these advanced analytical approaches could help bridge the gap between environmental monitoring and understanding actual human exposure levels. Better measurement tools are needed to assess how much microplastic people are consuming through their diet.
Integrative Biochemical Diagnostics: From Prenatal Genomics to Environmental and Behavioral Biomarkers
This short review proposes an integrative diagnostic framework linking advances in prenatal genomics, metabolic biomarkers, and environmental sensing, including detection of microplastics and endocrine-disrupting chemicals as emerging biomarkers of health risk.
Integrative Biochemical Diagnostics: From Prenatal Genomics to Environmental and Behavioral Biomarkers
This short review proposes an integrative diagnostic framework linking advances in prenatal genomics, metabolic biomarkers, and environmental sensing, including detection of microplastics and endocrine-disrupting chemicals as emerging biomarkers of health risk.
Simultaneous determination of persistent and emerging organic pollutants in microplastics
Researchers developed and validated a new analytical method to simultaneously detect 45 persistent and emerging organic pollutants sorbed onto microplastics. The method was tested on several polymer types including polypropylene and polyethylene, both pristine and weathered, using solvent extraction and gas chromatography-mass spectrometry. The study provides a practical tool for assessing the chemical contamination that microplastics can carry and transport through the environment.
Multi-residue ultra-performance liquid chromatography coupled with tandem mass spectrometry method for comprehensive multi-class anthropogenic compounds of emerging concern analysis in a catchment-based exposure-driven study
Researchers developed a multi-residue analytical method capable of simultaneously quantifying more than 142 anthropogenic compounds of emerging concern, including pharmaceuticals, pesticides, and plastic additives, in catchment water samples. This comprehensive method enables broad environmental screening to understand the co-occurrence of diverse chemical pollutants in freshwater systems.