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Study on toxicity effects of environmental pollutants based on metabolomics: A review

Chemosphere 2021 116 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 60 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Zhiyuan Meng, Li Liu, Qinchao Wu, Zhiyuan Meng, Qinchao Wu, Xinyi Miao, Wentao Zhu Wentao Zhu Zhiyuan Meng, Zhiyuan Meng, Wentao Zhu Xinyi Miao, Tianle Fan, Tianle Fan, Wentao Zhu Zhiyuan Meng, Wentao Zhu Xiaojun Chen, Wentao Zhu Xiaojun Chen, Wentao Zhu Zhiyuan Meng, Zhiyuan Meng, Zhiyuan Meng, Wentao Zhu Xiaojun Chen, Wentao Zhu Wentao Zhu Wentao Zhu

Summary

This review examines how metabolomics, a technology that measures changes in small molecules within organisms, is being used to study the toxic effects of environmental pollutants including microplastics, heavy metals, and pesticides. Researchers found that metabolomics can reveal subtle biological changes caused by pollutant exposure that traditional methods might miss. The study highlights metabolomics as a powerful tool for understanding how environmental contaminants disrupt normal biological processes at the molecular level.

In the past few decades, the toxic effects of environmental pollutants on non-target organisms have received more and more attention. As a new omics technology, metabolomics can clarify the metabolic homeostasis of the organism at the overall level by studying the changes in the relative contents of endogenous metabolites in the organism. Recently, a large number of studies have used metabolomics technology to study the toxic effects of environmental pollutants on organisms. In this review, we reviewed the analysis processes and data processes of metabolomics and its application in the study of the toxic effects of environmental pollutants including heavy metals, pesticides, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and microplastics. In addition, we emphasized that the combination of metabolomics and other omics technologies will help to explore the toxic mechanism of environmental pollutants and provide new research ideas for the toxicological evaluation of environmental pollutants.

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