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Papers
20 resultsShowing papers similar to Molecular mechanisms of polystyrene nanoplastics and alpha-amylase interactions and their binding model: A multidimensional analysis
ClearAssessment of polystyrene nano plastics effect on human salivary α-amylase structural alteration: Insights from an in vitro and in silico study
Researchers investigated how polystyrene nanoplastics interact with human salivary alpha-amylase, a key digestive enzyme, using both laboratory experiments and computer modeling. They found that the nanoplastics competitively inhibited the enzyme and caused structural changes including loss of secondary protein structure. The study suggests that nanoplastic exposure in the digestive system may interfere with normal enzyme function, raising concerns about potential impacts on human digestion.
Multispectroscopy analysis of polystyrene nanoplastic interaction with diastase α-amylase
Researchers used fluorescence spectroscopy and other analytical techniques to characterize how polystyrene nanoplastics bind to and alter the structure of alpha-amylase, a key digestive enzyme, suggesting nanoplastic exposure could potentially disrupt starch digestion.
Exposure of Polystyrene Micro- and Nanoplastics to Simulated Human Digestive Enzymatic Systems: Structural and Functional Implications
This lab study exposed polystyrene micro and nanoplastics to simulated human digestive enzymes including saliva, stomach acid, and pancreatic fluid to see how they interact. The researchers found that digestive enzymes bind to the plastic surfaces, potentially changing how the body processes food and absorbs nutrients. This suggests that swallowed microplastics could interfere with normal digestion, though more research is needed to confirm effects in living people.
Small polystyrene microplastics interfere with the breakdown of milk proteins during static in vitro simulated human gastric digestion
Researchers found that small polystyrene microplastics interfere with the digestion of milk proteins in a simulated human stomach environment. The microplastics adsorbed the digestive enzyme pepsin onto their surface, reducing its activity and slowing the breakdown of proteins like casein and whey. The study suggests that microplastic contamination in food could impair normal digestive processes in the human gut.
Spectroscopic investigations on the interaction between nano plastic and catalase on molecular level
Researchers investigated how polystyrene nanoplastics interact with the enzyme catalase at different pH levels, finding that nanoplastics alter the protein's secondary structure and reduce its enzymatic activity through static quenching and hydrophobic binding mechanisms.
Nanoplastics alter the conformation and activity of human serum albumin
Researchers investigated how polystyrene nanoplastics interact with human serum albumin, a key blood protein, and found that nanoplastics bind to the protein through hydrophobic forces, altering its structure and reducing its enzymatic activity. The study suggests that nanoplastic exposure could interfere with normal protein function in the bloodstream, highlighting the need for regulation of nanoplastics in consumer products.
Microplastics Reduce Lipid Digestion in Simulated Human Gastrointestinal System
Researchers found that five common types of microplastics all significantly reduced lipid digestion in a simulated human gastrointestinal system, with polystyrene causing the greatest inhibition at 12.7%. The microplastics interfered through two mechanisms: forming clumps with fat droplets that reduced their availability, and adsorbing digestive enzymes in ways that altered their structure and function. The study suggests that ingested microplastics may impair nutrient absorption by disrupting normal fat digestion processes.
The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics
Researchers studied how the human digestive process changes the physical and biological properties of polystyrene nanoplastics. They found that digestive fluids altered the surface characteristics of the particles, potentially affecting how they interact with gut cells. The study suggests that the form of nanoplastics that actually reaches our intestines may behave differently than the pristine particles typically used in lab studies.
Surface functionalized polystyrene nanoplastics impair nutrient assimilation from corn kernels (Zea mays L.) in a simulated human digestive tract
Researchers used a simulated human digestive system to test how polystyrene nanoplastics affect nutrient absorption from corn kernels. They found that the nanoplastics significantly reduced the bioaccessibility of beneficial plant compounds by 7-35% and decreased starch digestion from 95% to 74% by interfering with digestive enzymes. The findings suggest that nanoplastics co-ingested with food could impair the nutritional value of meals.
Unraveling the impact of polystyrene microplastics with varying particle sizes and concentrations on lipid in vitro digestion and ex vivo absorption
Researchers investigated how polystyrene microplastics of different sizes and concentrations affect fat digestion and absorption using laboratory and tissue-based models. They found that microplastics interfered with the digestive process by interacting with digestive enzymes and bile salts, and that smaller particles at higher concentrations had the greatest inhibitory effect on fat absorption. The findings suggest that microplastics consumed with food could alter how the body processes dietary fats.
Probing the molecular mechanism of interaction between polystyrene nanoplastics and catalase by multispectroscopic techniques
Researchers investigated the molecular mechanism of interaction between polystyrene nanoplastics and the antioxidant enzyme catalase using multispectroscopic techniques, revealing how nanoplastic accumulation may disrupt enzymatic function and contribute to oxidative stress.
Exploring the role of real food matrices on the behavior and toxicity of polystyrene nanoplastics during digestion simulation
Researchers investigated how polystyrene nanoplastics behave and affect cells when consumed alongside real food, using milk as the test matrix, during simulated digestion. They found that food proteins and digestive enzymes formed a coating around the nanoplastics that changed their aggregation behavior and reduced their toxicity compared to nanoplastics alone. The study suggests that the presence of food during digestion may significantly alter how nanoplastics interact with the body, an important factor often overlooked in toxicity studies.
Interactions between polystyrene nanoplastics and bovine lactoferrin in simulated gastric fluids: Aggregation kinetics and impact on protein digestion
This study investigated how polystyrene nanoplastics with different surface charges interact with bovine lactoferrin in simulated gastric conditions, affecting both particle aggregation and protein digestion. The findings show that nanoplastic-protein interactions in the stomach could alter the digestibility of dietary proteins, with implications for nutritional and gut health.
Study on the binding of polystyrene microplastics with superoxide dismutase at the molecular level by multi-spectroscopy methods
Researchers used multiple spectroscopy methods to study how polystyrene microplastics interact with the antioxidant enzyme superoxide dismutase (SOD) at the molecular level. The study found that microplastics altered SOD's protein structure, forming larger complexes and increasing the enzyme's activity in a concentration-dependent manner, providing insights into how microplastics may affect biological antioxidant systems.
Polystyrene nanoplastics shape microbiome and functional metabolism in anaerobic digestion
Researchers studied how polystyrene nanoplastics and microplastics affect the microbial communities and biochemical processes in anaerobic digestion systems used for waste treatment. They found that nanoplastics had a more disruptive effect than microplastics, significantly altering the composition and metabolic functions of the microbial community. The study suggests that plastic contamination in waste streams could reduce the efficiency of anaerobic digestion, a widely used waste processing technology.
Effects of Polypropylene and Polyethylene Terephthalate Microplastics on Trypsin Structure and Function
Researchers investigated how polypropylene and PET microplastics interact with trypsin, a key digestive enzyme, and whether this affects the digestion of meat proteins. They found that while some trypsin molecules lost most of their activity after binding tightly to microplastic surfaces, the overall effect on protein digestion was minimal at realistic exposure levels. The study suggests that the concentrations of microplastics typically encountered in the gut are unlikely to significantly impair the digestion of meat proteins.
Unveiling the Modification of Esterase-like Activity of Serum Albumin by Nanoplastics and Their Cocontaminants
Researchers investigated how polystyrene nanoplastics with different surface charges and sizes affect the enzymatic activity of human serum albumin, a key blood protein. The study found that amino-modified and smaller nanoplastics had the greatest impact on protein structure and inhibited its ability to metabolize compounds, while the presence of the drug metformin reduced nanoplastic binding to the protein. These findings suggest that nanoplastics could interfere with normal protein function in the bloodstream and that co-exposure with other chemicals may alter how nanoplastics are transported in the body.
Crowding Effects of Polystyrene Nanoparticles on Lactate Dehydrogenase Activity in Hydra Attenuata
Researchers examined how polystyrene nanoparticles affect the activity of the enzyme lactate dehydrogenase through molecular crowding effects. The study contributes to understanding how nanoplastics might interact with proteins and enzymes in biological systems, potentially disrupting cellular metabolism.
Impact of a real food matrix and in vitro digestion on properties and acute toxicity of polystyrene microparticles
Researchers examined how interaction with milk as a real food matrix and subsequent digestion affects the properties and toxicity of polystyrene microparticles. The study found that milk proteins form a corona on the particles that alters their surface charge and behavior, suggesting that the food context significantly influences how microplastics behave in the gastrointestinal tract.
Deciphering the role of polystyrene microplastics in waste activated sludge anaerobic digestion: Changes of organics transformation, microbial community and metabolic pathway
Researchers found that polystyrene microplastics in sewage sludge affected the anaerobic digestion process used to treat waste, with low concentrations slightly boosting methane production but high concentrations reducing it by up to 11%. The microplastics disrupted key bacterial communities and enzyme activities needed for proper waste breakdown. This matters because wastewater treatment plants handle enormous volumes of microplastic-laden sludge, and impaired digestion could reduce treatment effectiveness and release more pollutants into the environment.