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20 resultsShowing papers similar to Quantitative monitoring of microplastics and lipid metabolism in live zebrafish via hyperspectral stimulated Raman scattering microscopy
ClearQuantitative assessment and monitoring of microplastics and nanoplastics distributions and lipid metabolism in live zebrafish using hyperspectral stimulated Raman scattering microscopy
Researchers developed a new imaging technique to watch microplastics and nanoplastics accumulate in live zebrafish in real time, without needing dyes or labels. They found that these tiny plastic particles built up in the fish's digestive system and disrupted fat metabolism, providing direct visual evidence of how micro- and nanoplastics can interfere with basic biological processes.
Label-free stimulated Raman scattering imaging of intracellular microplastics in mammalian cells
Researchers used label-free stimulated Raman scattering imaging to visualize microplastic uptake and distribution inside mammalian cells without fluorescent labels, finding that intracellular microplastics were associated with elevated reactive oxygen species, reduced cell viability, and altered lipid metabolism.
Mapping the Metabolic Characteristics and Perturbation of Adult Casper Zebrafish by Ambient Mass Spectrometry Imaging
Not relevant to microplastics — this study uses mass spectrometry imaging to map the metabolic profiles of transparent Casper zebrafish, revealing genetic mutation-driven changes in lipid and purine metabolism, with no connection to microplastic research.
Hyperspectral oblique plane microscopy enables spontaneous, label-free imaging of biological dynamic processes in live animals
Researchers developed a new high-speed Raman imaging microscope that can capture label-free, molecular-level images of biological processes in living animals. They demonstrated the technology by tracking microplastic accumulation in the organs of live zebrafish, visualizing particle distribution without any dyes or markers. This imaging advancement could significantly improve how scientists study microplastic uptake and distribution in living organisms.
Visible Combined Near-Infrared in Situ Imaging Revealed Dynamic Effects of Microplastic Fibers and Beads in Zebrafish
Researchers used a combined visible and near-infrared imaging technique to track microplastic fibers and beads in live zebrafish in real time. They observed that microplastics were quickly ingested and could be retained briefly in the digestive tract before being eliminated. The study provides new insights into the dynamic behavior of microplastics inside living organisms and whether any tissue damage that occurs during transit can be reversed.
Mass spectrometry imaging enables detection of MPs and their effects in Daphnia magna following acute exposure
Researchers used an advanced imaging technique called mass spectrometry imaging to track where microplastics accumulate inside water fleas after short-term exposure. They found that the tiny organisms ingested microplastics that concentrated in their gut, and the exposure altered their lipid metabolism. The technique offers a new way to visualize exactly where microplastics end up in small aquatic organisms and what biochemical changes they cause.
Impacts of polypropylene microplastics on lipid profiles of mouse liver uncovered by lipidomics analysis and Raman spectroscopy
Researchers found that polypropylene microplastics accumulated in mouse liver tissue and caused significant changes to lipid metabolism, even without obvious outward health symptoms. Advanced analysis revealed altered fat profiles and lipid droplet buildup in the liver. This study suggests that microplastic exposure could quietly disrupt liver fat processing, which is relevant to understanding long-term metabolic health effects in mammals.
Particle size-dependent neurotoxicity of microplastics in zebrafish (Danio rerio): Spatially resolved lipidomics links metabolic dysregulation to neurological disorders
Researchers exposed zebrafish to polypropylene microplastics of different sizes and used spatial lipidomic imaging to show size-dependent disruptions in brain lipid metabolism, linking smaller particles to greater neurological disruption and identifying specific lipid dysregulation patterns.
Imaging and quantifying the biological uptake and distribution of nanoplastics using a dual-functional model material
Researchers developed a dual-functional nanoplastic model material that allows both imaging and precise quantification of nanoplastic uptake in biological systems. Using surface-enhanced Raman spectroscopy and inductively coupled plasma mass spectrometry, they could track where nanoplastics accumulated in organisms at high resolution. The tool addresses a major gap in nanoplastic research by enabling more accurate measurement of how these tiny particles interact with living tissues.
Correlative spectroscopy and microscopy analysis of micro- and nanoplastics in complex biological matrices
Researchers combined fluorescence, second harmonic generation, and coherent Raman scattering microscopy in a single instrument to image micro- and nanoplastics in lung cells, zebrafish, and mouse tissues. Polystyrene nanoplastics crossed the blood-brain barrier and accumulated in lipid-rich brain regions in mouse models.
Hyperspectral Imaging Based Method for Rapid Detection of Microplastics in the Intestinal Tracts of Fish
Researchers developed a hyperspectral imaging-based method to directly detect and identify microplastics in fish intestinal tracts without requiring tissue digestion or particle extraction, enabling faster and less reagent-intensive analysis compared to conventional Raman or FTIR approaches.
Hyperspectral Oblique Plane Microscopy Enables Spontaneous, Label-Free Imaging of Biological Dynamic Processes in Live Animals
Researchers developed a single-objective light-sheet microscope called lambda-OPM that records spontaneous Raman spectral images at millisecond-to-minute timescales, demonstrating its ability to identify microplastic particles by polymer type and to capture real-time molecular changes in live zebrafish embryo wound healing and beating heart tissue.
Correlative spectroscopy and microscopy analysis of micro- and nanoplastics in complex biological matrices
Researchers combined fluorescence microscopy, second harmonic generation imaging, and coherent Raman scattering to detect and map micro- and nanoplastics in lung cells, zebrafish, and mouse tissues. Polystyrene nanoplastics were found to cross the blood-brain barrier and accumulate in lipid-rich brain regions in animal models.
Limits of the detection of microplastics in fish tissue using stimulated Raman scattering microscopy
This study demonstrated the detection sensitivity of stimulated Raman scattering microscopy for identifying microplastic beads within fish tissue, characterizing how signal-to-noise ratio varies with particle size. The technique provided chemical contrast to distinguish different plastic types within biological tissue without destructive sample preparation.
Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver
Researchers exposed zebrafish to polystyrene microplastics of two different sizes and tracked where the particles accumulated in the body. They found that smaller particles (5 micrometers) built up in the gills, liver, and gut, while larger particles (20 micrometers) mainly stayed in the gills and gut. The microplastics caused liver inflammation, oxidative stress, and disrupted fat metabolism, suggesting that ingested microplastics can damage internal organs in fish.
Quantitative Tracking of Nanoplastic Uptake and Distributionin Zebrafish by Single-Particle Inductively Coupled Plasma Mass Spectrometry
Researchers developed a framework using europium-doped polystyrene nanoplastics as tracers, combined with single-particle inductively coupled plasma mass spectrometry, to quantitatively track nanoplastic uptake and distribution in zebrafish at the single-particle level. This method enabled real-time, size-resolved tracking of nanoplastics accumulating in different fish organs over time.
Polystyrene microbeads influence lipid storage distribution in C. elegans as revealed by coherent anti-Stokes Raman scattering (CARS) microscopy
Researchers used coherent anti-Stokes Raman scattering microscopy to show that polystyrene microbead exposure altered lipid storage distribution in C. elegans, linking microplastic-induced feeding impairment to changes in energy reserves important for reproduction and stress response.
Detection of unlabeled nanoplastics within Daphnia magna using enhanced darkfield hyperspectral microscopy
Researchers developed a method to detect unlabeled nanoplastics within Daphnia magna using enhanced darkfield hyperspectral microscopy combined with a post-exposure histological labeling process. The study presents a new approach for identifying nanoplastic particles in model organisms without requiring pre-labeled or fluorescent plastics.
Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish
Researchers tracked the accumulation and distribution of fluorescent microplastics in early life stages of a freshwater organism, finding that microplastics were taken up and distributed across body tissues. The results help explain how microplastics accumulate in young aquatic organisms and potentially affect their development.
Unveiling microplastics with hyperspectral Raman imaging: From macroscale observations to real-world applications
This study demonstrated that hyperspectral Raman imaging can identify and characterize microplastics across scales from macro observations to individual particles in real environmental samples, offering advantages over single-point Raman measurements for heterogeneous samples.