Papers

20 results
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Article Tier 2

Black Lycium barbarum polysaccharide attenuates LPS-induced intestine damage via regulation gut microbiota

Researchers studied whether a polysaccharide from black Lycium barbarum could protect against intestinal damage caused by bacterial toxins in mice. They found that the supplement alleviated intestinal tissue damage and improved gut microbiota diversity by promoting beneficial bacteria. The study suggests that this plant-derived polysaccharide may help maintain intestinal health by modulating the gut microbial community.

2023 Frontiers in Microbiology 16 citations
Article Tier 2

Carvacrol attenuated lipopolysaccharide-induced intestinal injury by down-regulating TLRs gene expression and regulating the gut microbiota in rabbit

Researchers tested whether carvacrol, a natural plant compound found in oregano and thyme, could protect the intestines of rabbits challenged with a bacterial toxin (lipopolysaccharide), finding it reduced inflammation, improved gut lining structure, and restored healthier gut bacteria communities. These results suggest carvacrol could be a useful dietary supplement for protecting intestinal health in rabbit farming.

2023 Scientific Reports 9 citations
Article Tier 2

Inhibitory Effects of Jiuzao Polysaccharides on Alcoholic Fatty Liver Formation in Zebrafish Larvae and Their Regulatory Impact on Intestinal Microbiota

Researchers investigated the protective effects of Laowuzeng Jiuzao polysaccharides on ethanol-induced alcoholic fatty liver in zebrafish larvae, finding that the polysaccharides reduced hepatic damage and regulated intestinal microbiota composition, suggesting therapeutic potential for alcohol-related liver disease.

2024 Foods 1 citations
Article Tier 2

Lactobacillus plantarum A3 attenuates ulcerative colitis by modulating gut microbiota and metabolism

Researchers showed that Lactobacillus plantarum A3, a probiotic strain isolated from horses, reduced symptoms of ulcerative colitis in mice whose gut microbiomes had been disrupted by antibiotics. The probiotic restored beneficial bacteria like Akkermansia, reduced gut inflammation, and increased levels of natural anti-inflammatory compounds in the body.

2023 Animal Diseases 22 citations
Article Tier 2

Combined Omics Analysis Further Unveils the Specific Role of Butyrate in Promoting Growth in Early-Weaning Animals

Researchers investigated whether dietary butyrate supplementation could improve intestinal health and growth in early-weaned rabbits using combined transcriptomic and metabolomic analysis. They found that butyrate strengthened the intestinal barrier, improved gut microbial balance by suppressing harmful bacteria, and enhanced metabolic pathways related to inflammation reduction and antioxidant capacity. The study suggests that butyrate supplementation may help alleviate the intestinal disruption commonly caused by early weaning in young animals.

2023 International Journal of Molecular Sciences 17 citations
Article Tier 2

Carvacrol attenuated lipopolysaccharide-induced intestinal injury by down-regulating TLRs gene expression and regulating the gut microbiota in rabbit

This study examined how carvacrol (a natural plant compound) reduces intestinal inflammation and protects gut microbiota in rabbits challenged with bacterial toxins. Understanding how the gut microbiome responds to different stressors provides context for research on microplastic effects on intestinal health.

2023 Research Square (Research Square) 1 citations
Article Tier 2

Impacts of dietary supplementation of bamboo vinegar and charcoal powder on growth performance, intestinal morphology, and gut microflora of large-scale loach Paramisgurnus dabryanus

Researchers fed large-scale loach fish diets supplemented with 1–2% bamboo vinegar and charcoal powder for 90 days and found significant improvements in survival, weight gain, intestinal villus length, and gut microbiome composition, suggesting this additive promotes digestive health and growth in aquaculture.

2023 Journal of Oceanology and Limnology 7 citations
Article Tier 2

Ameliorative effects of mulberry fruit anthocyanin extract on gut microbiota and liver metabolites in high-fat and high-cholesterol diet-fed ApoE−/− mice

Researchers investigated mulberry anthocyanin extract in high-fat, high-cholesterol diet-fed mice and found it reduced LDL cholesterol and inflammatory markers while favorably shifting gut microbial composition and modulating liver metabolites including glutamine and ATP, suggesting a mechanism linking gut microbiota to atherosclerosis risk reduction.

2026 Frontiers in Nutrition
Article Tier 2

Jianwei Xiaoshi oral liquid attenuates high-calorie diet-induced dyspepsia in immature rats via regulating the pancreatic secretion pathway and maintaining the homeostasis of intestinal microbiota

Researchers found that a traditional Chinese herbal medicine formula called Jianwei Xiaoshi oral liquid improved functional digestive problems in young rats fed a high-calorie diet by regulating eight key proteins involved in pancreatic digestion and restoring healthy gut bacteria balance. The findings suggest potential therapeutic benefits of this herbal remedy for diet-induced digestive disorders in children.

2025 Chinese Medicine 1 citations
Article Tier 2

Chestnut Shell Tannins: Effects on Intestinal Inflammation and Dysbiosis in Zebrafish

Researchers tested chestnut shell tannin extract in zebrafish with induced intestinal inflammation and dysbiosis, finding that tannin treatment reduced inflammatory markers and partially restored gut microbiome composition, suggesting potential as a natural anti-inflammatory dietary supplement.

2021 Animals 39 citations
Article Tier 2

Tanshinone IIA May Inhibit Gastric Cancer via Affecting the Intestinal Microbiome

Researchers investigated whether tanshinone IIA, a compound derived from Salvia miltiorrhiza, inhibits gastric cancer tumor growth through modulation of the intestinal microbiome and regulation of NF-kB signaling. The study found that tanshinone IIA altered the gut microbial composition and suppressed NF-kB pathway activity, suggesting a microbiome-mediated mechanism underlying its anti-tumor effects.

2022 Computational and Mathematical Methods in Medicine 2 citations
Article Tier 2

Improvement of the intestinal epithelial barrier during laxative effects of phlorotannin in loperamide-induced constipation of SD rats

Researchers found that phlorotannin, a natural compound found in brown seaweed, relieves constipation in rats by repairing the intestinal epithelial barrier — the protective lining of the gut — suggesting it may support healthy gut function.

2023 Laboratory Animal Research 10 citations
Article Tier 2

Mechanism of Mulberry Leaves and Black Sesame in Alleviating Slow Transit Constipation Revealed by Multi-Omics Analysis

Researchers examined how mulberry leaves and black sesame alleviate slow transit constipation in a mouse model, measuring gut motility, microbiota composition, and intestinal gene expression. Both dietary interventions increased beneficial bacteria, enhanced gut peristalsis, and upregulated genes associated with intestinal motility, supporting their traditional use for digestive health.

2024 Molecules 1 citations
Article Tier 2

Potential of Fermented Plant Extract for Removing Microplastics in Artificial Gastric and Intestinal Juices

This study tested whether fermented plant extract could accelerate microplastic excretion from the gastrointestinal tract in an animal model, finding that the extract promoted intestinal motility and MP passage, suggesting a potential natural approach to reducing residence time of ingested MPs.

2025 Current Nutrition & Food Science
Article Tier 2

The potential mechanism of huazhuojiedu decoction in the treatment of ulcerative colitis based on network pharmacology and experimental validation

Researchers used network pharmacology to identify 119 active components and 146 potential targets of the traditional Chinese medicine formula Huazhuojiedu decoction relevant to ulcerative colitis, then validated key predicted mechanisms in dextran sulfate sodium-induced rat colitis models, elucidating multi-target pathways underlying the formula's clinically observed therapeutic effects.

2022 Frontiers in Pharmacology 3 citations
Article Tier 2

The interplay between root exudates and Cross-kingdom synthetic microbiota enhances the resistance of Vicia faba to Fusarium wilt disease

This study found that cross-kingdom synthetic microbiota consisting of bacteria and fungi, in combination with root exudate signals from Vicia faba, can significantly enhance plant resistance to Fusarium wilt disease by restructuring the rhizosphere microbial community.

2024 Research Square (Research Square)
Article Tier 2

An Ilex latifolia‐containing compound tea regulates glucose–lipid metabolism and modulates gut microbiota in high‐fat diet‐fed mice

This study investigated how a compound tea containing Kuding Tea, green tea, and Luohan fruit affects glucose and lipid metabolism in mice fed a high-fat diet. Researchers found that the tea blend helped regulate metabolic parameters and modulated gut microbiota composition, suggesting potential benefits for managing metabolic health.

2024 Food Frontiers 2 citations
Clinical Trial Tier 1

Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study

This Mendelian randomization study found genetic evidence supporting a causal relationship between specific gut microbiota compositions and gastrointestinal diseases. The findings suggest that microbiome-related interventions, including microbiome-dependent metabolites, could potentially be developed to treat or manage gastrointestinal conditions.

2024 Journal of Translational Medicine 36 citations
Article Tier 2

Comparative analysis of gut fungal composition and structure of the yaks under different feeding models

Researchers compared the gut fungal communities of wild yaks, house-fed domestic yaks, and grazing domestic yaks on the Tibetan plateau. They found that wild and grazing yaks had significantly more diverse gut fungal communities than house-fed yaks, with the feeding model strongly influencing which fungal species thrived. The study suggests that natural grazing supports a richer gut microbiome in yaks compared to indoor feeding, with potential implications for animal health and digestion.

2023 Frontiers in Veterinary Science 16 citations
Article Tier 2

The effects of food provisioning on the gut microbiota community and antibiotic resistance genes of Yunnan snub-nosed monkey

Researchers compared the gut bacteria and antibiotic resistance genes of Yunnan snub-nosed monkeys that receive supplemental food from a reserve with those of wild-foraging groups. The study found differences in microbial communities between the two groups, suggesting that food provisioning programs, while helpful for population recovery, may alter the gut health of these endangered primates.

2024 Frontiers in Microbiology 5 citations