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20 resultsShowing papers similar to Pathophysiological impact of chronic exposure of ciprofloxacin antibiotic residue above the MRL level in mice
ClearToxicity effects of Ciprofloxacin on biochemical parameters, histological characteristics, and behaviors of Corbicula fluminea in different substrates
Researchers found that the antibiotic ciprofloxacin in river sediments caused liver damage, immune suppression, and behavioral changes in freshwater clams. This shows that sediment-associated pharmaceutical pollutants—which often co-occur with microplastics in riverbed sediments—can harm important filter-feeding organisms.
Microplastic-contaminated antibiotics as an emerging threat to mammalian liver: enhanced oxidative and inflammatory damages
Researchers used a mouse model to study what happens when microplastics contaminated with antibiotics are ingested together, simulating real-world food chain exposure. The study found that the combination caused enhanced oxidative stress and inflammatory damage in the liver compared to either pollutant alone. The findings suggest that microplastics carrying adsorbed antibiotics may pose a greater threat to liver health than microplastics or antibiotics individually.
Biological toxicity of sulfamethoxazole in aquatic ecosystem on adult zebrafish (Danio rerio)
Not relevant to microplastics — this study examines how the antibiotic sulfamethoxazole affects zebrafish health, finding that chronic exposure causes liver and gill oxidative damage and disrupts gut bacteria, with no focus on plastic pollution.
Meta-analysis unravels the complex combined toxicity of microplastics and antibiotics in aquatic ecosystems
A meta-analysis of 730 datasets found that microplastics amplify antibiotic accumulation in aquatic organisms and worsen effects on growth, development, and immune function, but paradoxically appear to mitigate reproductive toxicity from antibiotics. The impact depends on biological response pathway, microplastic concentration, antibiotic properties, and exposure time, with an inverse relationship between antibiotic toxicity and both microplastic concentration and exposure duration.
The Research Status, Potential Hazards and Toxicological Mechanisms of Fluoroquinolone Antibiotics in the Environment
This review summarizes the environmental presence and toxic effects of fluoroquinolone antibiotics, which are widely used in human and animal medicine. These antibiotics can harm a range of organisms through mechanisms like oxidative stress and DNA damage. While not directly about microplastics, it is relevant because microplastics can carry adsorbed antibiotics through the environment, potentially amplifying their spread and impact.
Effects of microplastics and tetracycline on intestinal injury in mice
Researchers found that mice exposed to both microplastics and the antibiotic tetracycline suffered more intestinal damage than those exposed to either pollutant alone. The combined exposure caused distinct injuries across different segments of the intestine and disrupted gut bacteria composition. This is concerning because humans are commonly exposed to both microplastics and antibiotic residues through food and water.
Effects of Single and Combined Ciprofloxacin and Lead Treatments on Zebrafish Behavior, Oxidative Stress, and Elements Content
Researchers assessed the combined acute effects of the antibiotic ciprofloxacin and lead on zebrafish at environmentally relevant concentrations. The study found that the mixture caused more severe impacts than individual substances, including reduced swimming activity, disrupted mineral balance, inhibited acetylcholinesterase activity, and increased oxidative stress. These findings highlight that the co-occurrence of antibiotics and heavy metals in aquatic environments may pose greater risks to organisms than either pollutant alone.
Aged microplastics enhance their interaction with ciprofloxacin and joint toxicity on Escherichia coli
Researchers found that aged microplastics showed enhanced adsorption of the antibiotic ciprofloxacin compared to pristine particles, and that their combined exposure produced greater toxicity to E. coli at the molecular level than either pollutant alone.
Effect of chlorpyrifos on freshwater microbial community and metabolic capacity of zebrafish
Researchers exposed zebrafish and their surrounding water to chlorpyrifos, a widely used pesticide, and found it disrupted the diversity of aquatic microbes, increased dangerous antibiotic-resistant bacteria, and altered the gut metabolism of fish — raising concerns about the ecological and food-safety risks of pesticide runoff into waterways.
Impact of microplastics pollution on ciprofloxacin bioaccumulation in the edible mussel (Perna viridis): Implications for human gut health risks
Researchers studied how microplastics affect the accumulation of the antibiotic ciprofloxacin in edible green mussels from a mariculture farm. They found that microplastics altered the way mussels absorbed and retained the antibiotic, with implications for human gut health when contaminated seafood is consumed. The study highlights the compounding food safety risks when multiple pollutants interact in aquaculture environments.
The problem of contamination of aquatic ecosystems with antibiotics (a review)
This review examines the contamination of aquatic ecosystems by antibiotics, synthesizing global data on risks associated with antibiotic presence in ocean and freshwater environments, including effects on aquatic organisms and the promotion of antibiotic resistance. The authors assess quantitative and qualitative contamination using bivalves as bioindicators and evaluate the spread of resistance genes through aquatic biocenoses.
The occurrence of microplastic in specific organs in commercially caught fishes from coast and estuary area of east China
Researchers studied how polyethylene microplastics interact with the antibiotic ciprofloxacin in aquatic environments and found that the plastic particles can absorb and concentrate the drug on their surface. The adsorption capacity increased with weathering of the plastic, suggesting that aged microplastics in the environment are more effective carriers of pharmaceutical pollutants. The findings raise concerns that microplastics could transport antibiotics through water systems, potentially contributing to antimicrobial resistance.
Oxidative Stress Biomarkers and Antioxidant Enzymes in Liver and White Muscle of Nile Tilapia, Oreochromis niloticus , Exposed to an Endocrine Disruptor, Triclosan
Researchers investigated the effects of the antimicrobial chemical triclosan on Nile tilapia fish over 45 days of exposure at sublethal concentrations. They found that triclosan altered blood biochemistry, elevated antioxidant enzyme activity, and caused oxidative stress in both liver and muscle tissues. The study suggests that even low-level chronic exposure to triclosan in waterways can cause significant physiological harm to non-target aquatic organisms.
Dynamics of Gut Microbiome and Transcriptome in Korea Native Ricefish (Oryzias latipes) during Chronic Antibiotics Exposure
Researchers found that chronic low-dose exposure to erythromycin and ampicillin antibiotics disrupted the gut microbiome composition and altered immune and stress gene expression in Japanese rice fish (Oryzias latipes), suggesting that antibiotic residues in aquatic environments can cause lasting physiological effects in fish.
Procaine penicillin alters swimming behaviour and physiological parameters of Daphnia magna
Researchers found that procaine penicillin — a beta-lactam antibiotic detected in surface waters — altered swimming behavior, oxygen consumption, heart rate, and thoracic limb movement in the freshwater invertebrate Daphnia magna at concentrations of 11.79 mg/L.
The interaction between polyethylene microplastics and ciprofloxacin on inducing hepatotoxicity in Carassius auratus via the gut-liver axis
Researchers co-exposed crucian carp to polyethylene microplastics and the antibiotic ciprofloxacin and assessed liver toxicity through the gut-liver axis. The combination caused greater hepatic injury than either contaminant alone—disrupting gut microbiota, increasing intestinal permeability, and amplifying liver inflammation—highlighting synergistic toxicity when fish are exposed to both antibiotic and plastic pollution.
Bacterial dynamics of the plastisphere microbiome exposed to sub-lethal antibiotic pollution.
This study investigated how sub-lethal antibiotic concentrations in water interact with microplastic-associated biofilm communities (the plastisphere), finding that combined pollution alters bacterial dynamics and may contribute to antibiotic resistance selection in aquatic environments.
Controlling factors and toxicokinetic modeling of antibiotics bioaccumulation in aquatic organisms: A review
This review examines how antibiotics accumulate in aquatic organisms, identifying several commonly used veterinary and human antibiotics — including enrofloxacin and azithromycin — with high bioaccumulation potential in fish and invertebrates. Antibiotic accumulation in seafood raises concerns about human health exposure and the spread of antibiotic resistance through the food chain.
An Overview of Antibiotics as Emerging Contaminants: Occurrence in Bivalves as Biomonitoring Organisms
Researchers reviewed the occurrence of antibiotic residues in bivalve mollusks used as biomonitoring organisms across European, American, and Asian coastlines. They found that macrolides, sulfonamides, and quinolones were the most frequently detected antibiotic classes, though the health risk from consuming contaminated bivalves was generally assessed as negligible. The study emphasizes the importance of continued monitoring to prevent the development of antimicrobial resistance from environmental antibiotic contamination.
Combined Toxicity of Microplastics and Antimicrobials on Animals: A Review
This review summarizes research on the combined toxic effects of microplastics and antimicrobial agents (like antibiotics) on animals in both water and land environments. When microplastics carry antimicrobials, the combined exposure is often worse than either pollutant alone, causing greater damage to immune systems, reproduction, and gut bacteria. This is concerning for human health because microplastics in the environment can concentrate antibiotics and spread antibiotic resistance.