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Pathophysiological impact of chronic exposure of ciprofloxacin antibiotic residue above the MRL level in mice
Summary
Researchers chronically exposed organisms to ciprofloxacin antibiotic residues at environmentally relevant concentrations, measuring physiological and pathological responses. Ciprofloxacin exposure caused oxidative stress, tissue damage, and dysregulation of immune markers, suggesting that sub-therapeutic antibiotic concentrations common in polluted water pose meaningful health risks to aquatic organisms.
The research was investigated in mice. The mice were acclimatized and randomly divided into two groups namely the control and treated groups (n=10) respectively. The treated mice were supplied ciprofloxacin antibiotic 50ppm drinking water ad libitum for a consecutive period of one year. The body weight of treated mice was found significantly higher from 3rd month onwards. The pattern of body weight was highest in the 10th month followed by decreasing in pattern but was significant until the day of sacrifice. Treated mice showed a decreased number of lymphocytes, neutrophils & monocyte. Both ALT and AST enzymes up-regulated in treated mice. Liver histopathology showed steatosis, enlarged central vein, and infiltration of inflammatory cells into the central vein. Kidney histopathology demonstrated atrophy, fragmentation of glomeruli, degeneration & necrosis. TLC analysis revealed ciprofloxacin antibiotic residue further deposited antibiotic residue in the liver, kidney, spleen, intestine, breast muscle, and thigh muscle.
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