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61,005 resultsShowing papers similar to Cellular response of keratinocytes to the entry and accumulation of nanoplastic particles
ClearProspects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
Researchers isolated nanoplastic particles from commercial face scrubs and found they were internalized by human skin cells (keratinocytes) through a macropinocytosis pathway, triggering cellular stress responses. The findings raise concerns about dermal exposure to nanoplastics from cosmetic products.
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
Researchers isolated nano-sized plastic particles from commercial face scrubs and tested their effects on human skin cells (keratinocytes), finding that plastic nanoparticles adhered to cells and were taken up into them. This raises concerns about microplastic absorption through the skin from cosmetic products.
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
Nano-sized plastic particles extracted from commercial face scrubs were taken up by human skin cells in lab experiments, triggering cellular stress responses and potentially damaging cell membranes. This raises concern about dermal exposure to nanoplastics from widely used personal care products.
[Microplastic and skin-an update].
This review summarizes current evidence on microplastics (1–5000 µm) and nanoplastics as skin-relevant pollutants, covering how they enter and interact with skin tissue. Evidence suggests dermal uptake is possible, particularly through damaged skin, and that these particles may carry additional chemical hazards.
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
Researchers isolated nano-sized plastic particles from commercial face scrubs and exposed human skin cells (keratinocytes) to them in the lab. They found that the nanoplastics adhered to the keratin layer, were internalized by cells through macropinocytosis, and caused dose-dependent effects including oxidative stress, reduced cell growth, and signs of premature cellular aging.
Penetration of Microplastics and Nanoparticles Through Skin: Effects of Size, Shape, and Surface Chemistry
This review examines how micro- and nanoplastics can penetrate human skin, with smaller particles being more likely to pass through. Beyond direct toxicity, these tiny plastic particles may also carry harmful chemicals through the skin barrier, acting as unwanted delivery vehicles for toxic substances we encounter in the environment.
The effects of size and surface functionalization of polystyrene nanoplastics on stratum corneum model membranes: An experimental and computational study
Researchers studied how polystyrene nanoplastics of different sizes and surface modifications interact with the outermost layer of human skin, the stratum corneum. Using both experiments and computer simulations, they found that particle size and surface chemistry significantly affected how nanoplastics disrupted skin barrier membranes. The study provides early evidence that nanoplastics could potentially compromise the skin's protective barrier, which is relevant to understanding dermal exposure risks.
Microplastics, Skin Disease, and Dermatology
This review examined the risks that microplastics and nanoplastics pose to skin health, noting that particles can penetrate compromised skin barriers and cause oxidative stress, inflammation, and cellular senescence in fibroblasts. The authors recommend that dermatologists incorporate microplastic exposure into clinical assessments of skin conditions.
Human skin and micro- and nanoplastics: a mini-review
This review explores how micro- and nanoplastics interact with human skin, a less-studied route of exposure compared to ingestion and inhalation. Researchers found that tiny plastic particles can penetrate the skin barrier through cosmetics, contaminated water, and airborne pollution. The study suggests that skin exposure to these particles may contribute to overall human microplastic burden, though more research is needed to fully understand the health implications.
Deciphering the links: Fragmented polystyrene as a driver of skin inflammation
Researchers tested fragmented polystyrene particles on human skin using cell cultures, live mice, and donated human skin samples, finding that these microplastics can penetrate skin layers and trigger significant inflammation. The particles were taken up by skin cells and caused the release of inflammatory signals, suggesting that everyday skin contact with microplastics in cosmetics, textiles, and dust could contribute to skin irritation and inflammatory skin conditions.
Environmental protein corona on nanoplastics altered the responses of skin keratinocytes and fibroblast cells to the particles
This study found that when nanoplastics pick up a natural protein coating from seawater, they interact with human skin cells differently than bare nanoplastics. The protein-coated particles entered skin cells through new pathways and triggered inflammatory responses, including signals linked to immune activation. This is important because it means nanoplastics in the real environment may be more biologically active than what lab studies using clean particles suggest.
Nanopartículas y salud dermatológica: mecanismos biológicos que afectan la barrera cutánea
This bibliographic review investigated the long-term effects of nanoparticles used in cosmetics on the skin barrier, finding that nanoparticles can alter lipid composition, modify intercellular junction protein expression, trigger inflammatory responses, and negatively affect cutaneous microbiota — collectively compromising the skin's protective function.
The physiological effect of polystyrene nanoplastic particles on fish and human fibroblasts
Researchers tested the effects of polystyrene nanoplastics on skin cells from both zebrafish and humans, finding that the particles were taken up by all cell types and slowed down cell growth and wound healing in a size- and concentration-dependent manner. Human skin cells were more sensitive than fish cells, with larger particles at higher concentrations causing the greatest inhibition of cell movement. These results suggest that nanoplastics contacting human skin could potentially interfere with normal skin repair processes.
Potential lifetime effects caused by cellular uptake of nanoplastics: A review
Researchers reviewed the potential lifetime health effects of nanoplastic uptake at the cellular level, noting that unlike larger micro- and macroplastics, nanoplastics can be absorbed directly by human cells. The study suggests that cellular uptake of nanoplastics may lead to various adverse effects including cytotoxicity, inflammation, and oxidative stress, though research on nanoplastic interactions with human cells is still in its early stages.
Microplastics in dermatology: Potential effects on skin homeostasis
This study highlights the growing concern that microplastics and nanoplastics may affect skin health by disrupting the skin's natural balance. While research is still early, the findings suggest that these synthetic particles could interfere with skin homeostasis, pointing to a need for further investigation into how everyday plastic exposure might affect our largest organ.
Impact of Microplastics and Nanoplastics on Human Health
This review explores how micro- and nanoplastics can enter the human body through the gut, lungs, and skin, and what potential health effects they might cause at the cellular level. While there is growing evidence that these particles trigger toxic responses in cells, research into their specific effects inside the human body is still limited. The paper calls for more studies on how nanoplastics in particular move through human tissue barriers and what long-term damage they may cause.
Short- and long-term polystyrene nano- and microplastic exposure promotes oxidative stress and divergently affects skin cell architecture and Wnt/beta-catenin signaling
Researchers exposed freshly isolated mouse skin cells to nano and microplastic particles of various sizes and found that the cells readily absorbed the plastics. While immediate toxicity was limited, the particles triggered oxidative stress, disrupted important cell signaling pathways including Wnt/beta-catenin (which controls cell growth), and caused skin cells to transform in ways associated with scarring. These findings suggest that chronic skin exposure to micro and nanoplastics could contribute to skin damage and abnormal wound healing over time.
Recent insights into uptake, toxicity, and molecular targets of microplastics and nanoplastics relevant to human health impacts
This review summarizes what scientists know about how tiny plastic particles enter the human body and cause harm at the cellular level, including through inflammation, oxidative stress, and disruption of important cell signaling pathways. Americans are estimated to consume tens of thousands to millions of micro- and nanoplastic particles per year, and these particles can penetrate cells and tissues throughout the body.
Understanding the Risk of Microplastic Dermal Absorption
This review examines the understudied pathway of microplastic absorption through the skin, highlighting a significant research gap compared to inhalation and ingestion routes. Researchers analyzed the potential mechanisms by which small plastic particles in skincare and cosmetic products could penetrate skin barriers. The study calls for more research into dermal absorption risks, particularly given the continued growth of the personal care product industry.
Perturbation of Nanoplastics on Biomembranes: Molecular Insights from Neutron Scattering
Scientists found that tiny plastic particles called nanoplastics can seriously damage cell membranes, which are the protective barriers around our cells. The plastic particles caused membranes to break apart and get thinner, though some natural cell types were more resistant to damage than others. This research helps us understand why the growing amount of plastic pollution in our environment and food could pose health risks to humans.
Impact of microplastics and nanoplastics on human Health: Emerging evidence and future directions
This review summarizes current evidence on how micro- and nanoplastics enter the human body through food, air, and skin contact, and the cellular damage they may cause. While microplastic pollution is a recognized environmental hazard, the authors note that definitive evidence linking plastic particle exposure to specific health outcomes in humans is still limited and more realistic exposure studies are needed.
In Vivo tracing and systemic organ biodistribution of dermally exposed nano polystyrene
Researchers used radiolabeled nano-sized polystyrene particles to trace how nanoplastics penetrate the skin and distribute throughout the body in a chronic dermal exposure model. They found that the nanoparticles were able to cross the skin barrier and translocate to multiple organs throughout the body. The study suggests that dermal exposure represents a potential route for systemic nanoplastic uptake, challenging assumptions about the skin's ability to fully block these particles.
Environmental exposure enhances the internalization of microplastic particles into cells
Researchers discovered that microplastic particles exposed to natural environmental conditions are taken up by cells at significantly higher rates than pristine, lab-fresh plastic particles. The study suggests that environmental weathering changes the surface properties of microplastics in ways that make them more likely to be absorbed into living tissue, which has important implications for understanding real-world exposure.
Impact of polyethylene terephthalate nanoplastics (PET) on fibroblasts: a study on NIH-3T3 cells
Researchers exposed mouse fibroblast cells (important for wound healing and tissue repair) to PET nanoplastics made through a process that mimics real-world plastic breakdown. The nanoplastics entered the cells and significantly impaired their ability to migrate and close wounds, even at concentrations that caused only mild reductions in cell survival. This suggests that nanoplastic exposure could interfere with the body's ability to heal wounds and repair damaged tissue.