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Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
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Researchers isolated nano-sized plastic particles from commercial face scrubs and exposed human skin cells (keratinocytes) to them in the lab. They found that the nanoplastics adhered to the keratin layer, were internalized by cells through macropinocytosis, and caused dose-dependent effects including oxidative stress, reduced cell growth, and signs of premature cellular aging.
BACKGROUND: Today, cosmetic products are very popular with both men and women to improve their appearance and increase their social acceptability. RESULTS: In this study, nano-sized (30-300 nm) plastic particles were isolated from the commercial face-scrubs and treated on the human keratinocytes. The observed adherence of polyethylene nano-plastics (PENPs), polystyrene NPs (PSNPs), and face-scrubs isolated nano-plastics (NPs) on the keratin layer reveals a significant attachment of NPs from the cosmetics that are applied on the skin for a short duration. This attachment property could facilitate further adherence of protein molecules on NPs and the protein-corona formation. The protein-corona mimics protein aggregates, thereby triggers macropinocytosis, followed by the macropinolysosomal process in the cell. These internalized NPs induced the concentration-dependent cytotoxic, cytostatic and cytoprotective activity in keratinocytes. Both single dose and chronic long-term exposure of lethal and sub-lethal concentrations of NPs resulted in oxidative stress-mediated down-regulation of cell growth and proliferation inhibition. Autophagic structures and premature aging were also observed using an electron microscopy and a senescence marker, respectively in the NPs internalized HaCaT cells incubated in a fresh, NPs-free medium. CONCLUSION: Though 2D culture models have many limitations, it produces significant conceptual advancements. This work provides an insight into the NPs concentration-dependent regulatory, cytoprotective, and cytotoxic effects in HaCaT cells. However, 3D model studies are required to identify the detailed mechanisms of NPs toxicity and cytoprotective events in cells at the molecular level.
More Papers Like This
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
AI summary Read the abstract
Researchers isolated nanoplastic particles from commercial face scrubs and found they were internalized by human skin cells (keratinocytes) through a macropinocytosis pathway, triggering cellular stress responses. The findings raise concerns about dermal exposure to nanoplastics from cosmetic products.
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
AI summary Read the abstract
Nano-sized plastic particles extracted from commercial face scrubs were taken up by human skin cells in lab experiments, triggering cellular stress responses and potentially damaging cell membranes. This raises concern about dermal exposure to nanoplastics from widely used personal care products.
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
AI summary Read the abstract
Researchers isolated nano-sized plastic particles from commercial face scrubs and tested their effects on human skin cells (keratinocytes), finding that plastic nanoparticles adhered to cells and were taken up into them. This raises concerns about microplastic absorption through the skin from cosmetic products.
Cellular response of keratinocytes to the entry and accumulation of nanoplastic particles
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Researchers studied how nanoplastic particles interact with human skin cells when the protective outer skin layer is compromised. They found that nanoplastics readily penetrate and accumulate inside skin cells, triggering stress responses and activating inflammatory pathways -- suggesting that people with damaged or sensitive skin may be especially vulnerable to nanoplastic absorption.
Physiological and Histological Characterization of Chemically Induced Nanoplastic Forced Skin Aging in Mice
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In a mouse study, tiny plastic particles (nanoplastics) combined with an aging-accelerating chemical caused significantly worse skin damage than either factor alone, weakening the skin's protective barrier, drying it out, and triggering inflammation and cell-damaging stress. This suggests that everyday exposure to nanoplastics, which are increasingly found in our environment, could speed up skin aging and harm skin health, especially when combined with other stressors our skin already faces.
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