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Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
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Nano-sized plastic particles extracted from commercial face scrubs were taken up by human skin cells in lab experiments, triggering cellular stress responses and potentially damaging cell membranes. This raises concern about dermal exposure to nanoplastics from widely used personal care products.
Abstract Background Today cosmetic usage becomes customary in both sexes to improve their appearance and increase societal visibility. In this study, we have isolated nano-sized plastic particles ranging between 30 to 300 nm from the commercial face-scrubs and investigated its effects on keratinocytes. Results Initially, nano-plastics adsorbed protein molecules and formed protein corona, thereby mimicked as protein aggregates, which then triggered the macropinocytosis activity. As a result, corrosion and degradation of plastic particles were observed. Concurrently, nano-plastics concentration-dependent cytotoxic, cytostatic, and cytoprotective activities were found in the keratinocytes. Additionally, a single dose of nano-plastics exposure resulted in the ROS mediated down-regulation of cell growth and proliferation inhibition followed by autophagy, finally, premature aging in HaCaT cells. Conclusion At the outset, this work provides insights into the nano-plastics concentration-dependent regulatory, cytoprotective, and cytotoxic effects in HaCaT cells. Further signifies the crucial need for new regulation in nano-plastics usage in cosmetics.
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Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
AI summary Read the abstract
Researchers isolated nanoplastic particles from commercial face scrubs and found they were internalized by human skin cells (keratinocytes) through a macropinocytosis pathway, triggering cellular stress responses. The findings raise concerns about dermal exposure to nanoplastics from cosmetic products.
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
AI summary Read the abstract
Researchers isolated nano-sized plastic particles from commercial face scrubs and tested their effects on human skin cells (keratinocytes), finding that plastic nanoparticles adhered to cells and were taken up into them. This raises concerns about microplastic absorption through the skin from cosmetic products.
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes
AI summary Read the abstract
Researchers isolated nano-sized plastic particles from commercial face scrubs and exposed human skin cells (keratinocytes) to them in the lab. They found that the nanoplastics adhered to the keratin layer, were internalized by cells through macropinocytosis, and caused dose-dependent effects including oxidative stress, reduced cell growth, and signs of premature cellular aging.
Cellular response of keratinocytes to the entry and accumulation of nanoplastic particles
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Researchers studied how nanoplastic particles interact with human skin cells when the protective outer skin layer is compromised. They found that nanoplastics readily penetrate and accumulate inside skin cells, triggering stress responses and activating inflammatory pathways -- suggesting that people with damaged or sensitive skin may be especially vulnerable to nanoplastic absorption.
Cellular responses to micro- and nanoplastics exposure: mechanisms and pathophysiological implications
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This review summarizes existing research on how tiny plastic particles interact with cells in lab and animal studies, finding repeated signs of cell stress, including damage to cell structures and inflammation. Studies also detected plastic material in human blood and tissue samples, but the review states this does not prove the particles cause specific diseases.
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