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Nanopartículas y salud dermatológica: mecanismos biológicos que afectan la barrera cutánea
Summary
This bibliographic review investigated the long-term effects of nanoparticles used in cosmetics on the skin barrier, finding that nanoparticles can alter lipid composition, modify intercellular junction protein expression, trigger inflammatory responses, and negatively affect cutaneous microbiota — collectively compromising the skin's protective function.
Este estudio de revisión bibliográfica investiga los efectos a largo plazo de las nanopartículas, utilizadas en cosméticos, sobre la función barrera de la piel. Analiza los mecanismos biológicos mediante los cuales estos compuestos pueden comprometer la integridad cutánea. Los hallazgos revelan que las nanopartículas pueden alterar la composición lipídica, modificar la expresión de proteínas de unión intercelular y desencadenar respuestas inflamatorias, lo que conduce a una disfunción de la barrera protectora. Además, la exposición prolongada puede afectar negativamente a la microbiota cutánea, exacerbando los riesgos para la salud dermatológica. El artículo presenta una visión integral de la toxicidad potencial de estos ingredientes y destaca la necesidad urgente de establecer protocolos de seguridad más estrictos en la industria cosmética. Concluye que se requieren estudios clínicos a largo plazo para evaluar las implicaciones reales de estos hallazgos, un conocimiento crucial para desarrollar productos más seguros y proteger el bienestar de los consumidores.
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