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61,005 resultsShowing papers similar to Disposition of [ 14 C]-polystyrene microplastics after oral administration to lactating sheep
ClearAbsorption, distribution, and elimination of [14C] polyethylene terephthalate nanoplastics in lactating sheep upon oral administration
Researchers tracked radiolabeled PET nanoplastics in lactating sheep after a single oral dose to understand how they are absorbed, distributed, and eliminated. They found that the vast majority (approximately 99 percent by 72 hours) was excreted through feces, with only trace amounts detected in plasma, milk, and tissues. The study suggests that dietary PET nanoplastics are largely passed through the digestive system rather than accumulating in body tissues, though low-level absorption into the bloodstream does occur.
Fate and disposition of [14C]-polystyrene microplastic after oral administration to laying hens
Researchers administered radioactively labeled polystyrene microplastics to laying hens and tracked their distribution through the body. The study found that less than 1% of the administered dose was absorbed into blood, eggs, or tissues, with nearly 97% recovered in excreta within the first day. Evidence indicates that polystyrene microplastics are poorly absorbed in poultry and would likely pass through the digestive system without significant accumulation.
Ultra-low dietary exposure to 14C-labelled polystyrene: evidencing translocation of nanoplastics in fish
Researchers synthesized carbon-14 radiolabelled polystyrene nanoplastics and fed them to rainbow trout at an ultra-low dietary concentration of 5.9 µg polystyrene/kg feed for two weeks, measuring radioactivity in mid intestine, hind intestine, kidney, and liver at days 3, 7, and 14 via liquid scintillation counting. Significantly elevated radioactivity was detected in the hind intestine and liver of exposed fish by day 14, with liver tissue equivalent to 1.8 µg polystyrene/g dry weight, demonstrating translocation of nanoplastics from the gut to systemic organs even at environmentally relevant low exposures.
Translocation of 14C-polystyrene nanoplastics into fish during a very-low concentration dietary exposure
Researchers used carbon-14 labeled polystyrene nanoplastics to trace their accumulation in rainbow trout fed a diet containing very low concentrations of the particles over two weeks. They found that nanoplastics translocated from the gut into internal organs, with significantly elevated radioactivity detected in the hind intestine and liver by day 14. The study demonstrates that even at extremely low dietary concentrations, nanoplastics can cross the intestinal barrier and distribute to fish tissues.
Blood uptake and urine excretion of nano- and micro-plastics after a single exposure.
Mice exposed to polystyrene nanoparticles (100 nm) and microparticles (3 µm) via different routes showed that smaller particles appeared rapidly in blood and were detected in urine, while larger particles cleared more slowly. The study provides direct evidence that nanoplastics can cross biological barriers and enter circulation, with potential for distribution throughout the body.
Impact of a real food matrix and in vitro digestion on properties and acute toxicity of polystyrene microparticles
Researchers examined how interaction with milk as a real food matrix and subsequent digestion affects the properties and toxicity of polystyrene microparticles. The study found that milk proteins form a corona on the particles that alters their surface charge and behavior, suggesting that the food context significantly influences how microplastics behave in the gastrointestinal tract.
Comparison of PET tracing and biodistribution between 64Cu-labeled micro-and nano-polystyrene in a murine inhalation model
Using radioactive copper labeling and PET imaging, researchers tracked where inhaled micro- and nano-sized polystyrene particles travel in the body, finding that nanoplastics distributed more widely to organs than microplastics after lung exposure. This is significant for understanding the health risks of airborne plastic particles, which people inhale daily from synthetic textiles, dust, and urban air.
PET Tracing of Biodistribution for Orally Administered 64Cu-Labeled Polystyrene in Mice
Researchers used PET imaging to track the real-time biodistribution of orally administered radiolabeled polystyrene microplastics in mice. The study found that microplastics were absorbed from the gastrointestinal tract and distributed to various organs, providing direct visual evidence of how ingested plastic particles can travel through the body.
Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo
Researchers studied the uptake and effects of orally ingested polystyrene microplastic particles using human intestinal cell models and rodent experiments. They found that smaller microplastics were taken up by intestinal cells and could cross the gut barrier, though the majority passed through the digestive system. The study suggests that while most ingested microplastics are excreted, a fraction can be absorbed, warranting further investigation into long-term health effects.
Accumulation of microplastics in edible tissues of livestock (cow and sheep)
Microplastics were found in edible tissues (muscle and liver) of cows and sheep, with detectable MP concentrations raising concerns about microplastic transfer into the human food chain through livestock consumption.
Digestion of Polystyrene Nanoparticles in a Whey Protein Drink. a Simulated in Vitro Gastrointestinal Digestion Using a Batch Infogest Model Combined with Cell Absorption Experiments
This study tracked polystyrene nano- and microplastic particles through a simulated digestive process mixed with a whey protein drink, then tested whether the particles could be absorbed by human intestinal cells. The work contributes to understanding how dietary microplastics survive digestion and whether they can pass through the gut lining into the body.
Development of a polystyrene-based microplastic model for bioaccumulation and biodistribution study using radiotracing and nuclear analysis method
Researchers developed a radiolabeled polystyrene microplastic model to track how microplastics move through and accumulate in living organisms. The study suggests that using radioactive tracers like iodine-131 allows for real-time, sensitive monitoring of microplastic behavior in biological systems, offering a more efficient alternative to conventional tracking methods.
Qualitative and quantitative analysis of microplastics in milk samples
Researchers analyzed microplastics in milk samples collected from branded products, dairies, and directly from cow sheds. They found microplastic particles present in the milk samples, with fibers being among the identified types. The study raises awareness about a potential dietary exposure pathway for microplastics through commonly consumed dairy products.
Nano-and Microplastics Migration from Plastic Food Packaging into Milk and Dairy Products: Impact on Nutrient Digestion, Absorption, and Metabolism
This review examined how nano- and microplastics migrate from plastic food packaging into milk and dairy products, discussing their potential impacts on nutrient digestion, absorption, and metabolism in the human body.
MassBalance Tracing of In Vivo Biodistribution,Relocation, and Excretion of Europium-Doped Micro/Nanoplastics inRats
This rat study used europium-labeled micro- and nanoplastics to track particle distribution in the body after intravenous administration, finding that most accumulated in the liver and spleen with very little reaching the brain or heart. The results suggest that standard biological filtration processes govern microplastic distribution following classical size-dependent rules.
Fate, uptake and impact of fit-for-purpose nanoplastics on the digestive environment: an in vitro-in vivo continuum study
Researchers investigated the fate, uptake, and impact of fluorescent and gold-labeled polystyrene nanoplastics on the digestive environment, using fit-for-purpose labeled particles to track nanoplastic behavior in biological systems. The labeled nanoplastics enabled detailed mapping of how plastic nanoparticles are processed in the gut, providing mechanistic insight into absorption pathways.
Impact of Exposure of Dairy Cow Feed to Polystyrene Microplastics on 24 h In Vitro Rumen Fermentation Responses, Microbiota Biodegradation Potential and Metabolic Pathways
Scientists found that when dairy cows eat feed contaminated with tiny plastic particles, it disrupts their digestion and changes the helpful bacteria in their stomachs. The cows' stomach bacteria can actually break down some of the plastic, but this process creates harmful chemicals that could affect milk production. This matters because microplastics are increasingly common in animal feed, which could potentially impact the safety and quality of dairy products we consume.
Assessing microplastic contamination in milk and dairy products
Researchers tested 28 dairy samples and found microplastics in all of them, with ripened cheese containing the highest levels at about 1,857 particles per kilogram, followed by fresh cheese and milk. The most common plastics found were PET, polyethylene, and polypropylene, likely coming from packaging materials, confirming that dairy products are another route of microplastic exposure for humans.
Mass Balance Tracing of In Vivo Biodistribution, Relocation, and Excretion of Europium-Doped Micro/Nanoplastics in Rats
Scientists injected tiny plastic particles into rats and tracked where they went in the body for three months. Most plastic particles collected in the liver and spleen, with smaller particles being harder for the body to get rid of—only 80% of the smallest particles were eliminated compared to just 15% of larger ones. This suggests that microplastics from food, water, and air could build up in our organs over time, though the long-term health effects are still unknown.
In Vivo tracing and systemic organ biodistribution of dermally exposed nano polystyrene
Researchers used radiolabeled nano-sized polystyrene particles to trace how nanoplastics penetrate the skin and distribute throughout the body in a chronic dermal exposure model. They found that the nanoparticles were able to cross the skin barrier and translocate to multiple organs throughout the body. The study suggests that dermal exposure represents a potential route for systemic nanoplastic uptake, challenging assumptions about the skin's ability to fully block these particles.
Connecting the Dots: Livestock Animals as Missing Links in the Chain of Microplastic Contamination and Human Health
This review highlights that farm animals are a missing link in understanding how microplastics move from contaminated soil and plants into the human food supply. Livestock can accumulate inhaled and ingested plastic particles, which may then transfer to people through meat, milk, and eggs. The authors call for standardized methods to measure microplastics in animal products to better understand this exposure pathway.
Biodistribution of europium-doped polystyrene nanoplastics in a model invertebrate organism
This study tracked the biodistribution of europium-labeled polystyrene nanoplastics in a model invertebrate using laser ablation ICP-MS, overcoming the analytical challenge of distinguishing nanoplastics from surrounding biological material in tissues. Organ-specific accumulation patterns were mapped, providing mechanistic data on nanoplastic fate after uptake in a small animal model.
Biodistribution of europium-doped polystyrene nanoplastics in a model invertebrate organism
This study used europium-doped polystyrene nanoplastics tracked by laser ablation inductively coupled plasma mass spectrometry to map biodistribution of plastic nanoparticles in a model invertebrate organism. The labeled tracer approach enabled precise organ-level mapping of nanoplastic distribution, revealing where plastic nanoparticles accumulate after exposure.
Occurrence of microplastics in edible tissues of livestock (cow and sheep)
Researchers found microplastics in the meat, liver, and stomach lining of both cows and sheep sold at butcher shops in Iran, with nylon being the most common plastic type detected. This study highlights that microplastics are transferring from the environment into livestock and could pose health risks to consumers, particularly children who eat meat.