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61,005 resultsShowing papers similar to Investigating the modulation of the endocannabinoid system by probiotic Lactiplantibacillus plantarum IMC513 in a zebrafish model of di-n-hexyl phthalate exposure
ClearThe probiotic SLAB51 as agent to counteract BPA toxicity on zebrafish gut microbiota -liver-brain axis
Researchers tested whether the probiotic supplement SLAB51 could counteract the harmful effects of bisphenol A (BPA), a plastic-derived chemical, in zebrafish and found it significantly restored healthy gut bacteria, reduced liver damage, and protected the brain — suggesting probiotics may help offset harm from plastic-associated chemical exposure.
Lactiplantibacillus plantarum P101 Alleviates Liver Toxicity of Combined Microplastics and Di-(2-Ethylhexyl) Phthalate via Regulating Gut Microbiota
Researchers found that the probiotic Lactiplantibacillus plantarum P101 reduced liver damage caused by combined exposure to microplastics and the plasticizer DEHP in mice. The probiotic reversed oxidative stress and inflammation in the liver and intestines while reshaping the gut microbiota. The study suggests that probiotic supplementation may offer a promising strategy for mitigating the toxic effects of co-exposure to microplastics and plastic-associated chemicals.
Damage of polyethylene microplastics on the intestine multilayer barrier, blood cell immune function and the repair effect of Leuconostoc mesenteroides DH in the large-scale loach (Paramisgurnus dabryanus)
Researchers found that polyethylene microplastics damage the intestinal lining of loach fish, allowing plastic particles to break through the gut barrier and enter the bloodstream, where they caused blood cell death. Adding a probiotic bacterium (Leuconostoc mesenteroides) to the fish's diet significantly repaired the intestinal damage and improved immune function. This suggests that probiotics may help counteract some of the gut damage caused by microplastic exposure.
Probiotics an emerging therapeutic approach towards gut-brain-axis oriented chronic health issues induced by microplastics: A comprehensive review
This review examines how microplastics disrupt the gut-brain axis, the communication system between the digestive system and the brain, leading to chronic health problems like inflammation and neurological issues. The authors highlight probiotics as a promising treatment approach, since beneficial bacteria can help repair gut damage caused by microplastic exposure. The findings suggest that supporting gut health through probiotics may help counteract some of the harmful effects of microplastics on both digestion and brain function.
Oxidized/unmodified-polyethylene microplastics neurotoxicity in mice: Perspective from microbiota-gut-brain axis
Mice exposed to both regular and environmentally weathered polyethylene microplastics developed brain and gut damage, including behavioral changes, weakened gut and blood-brain barriers, and inflammation -- with weathered microplastics causing even more harm. Importantly, treatment with a probiotic (Lactobacillus) and a prebiotic partially reversed these effects, suggesting that gut-friendly supplements might help protect against microplastic-related brain and intestinal damage.
Small fish, big discoveries: zebrafish shed light on microbial biomarkers for neuro-immune-cardiovascular health
This review highlighted how zebrafish serve as a powerful model for studying gut microbiome links to cardiovascular, neurological, and immune health, identifying microbial biomarkers that could inform future research on environmental stressor impacts including microplastic exposure.
DEHP chronic exposure disturbs the gut microbial community and metabolic homeostasis: Gender-based differences in zebrafish
Chronic exposure of zebrafish to DEHP — a phthalate plasticizer found in many plastic products — from embryo to adulthood disrupted gut microbial communities and metabolic balance, with effects that differed between males and females. This suggests that phthalate exposure from plastic products may alter gut health and metabolism in ways that could be relevant to human health.
Lactobacillus plantarum reduces polystyrene microplastic induced toxicity via multiple pathways: A potentially effective and safe dietary strategy to counteract microplastic harm
Researchers found that Lactobacillus plantarum, a probiotic bacterium commonly found in fermented foods, can reduce the harmful effects of polystyrene microplastics in mice through multiple pathways. The bacteria worked by binding directly to plastic particles to help remove them from the body, reducing oxidative damage, repairing the intestinal barrier, and regulating bile acid metabolism. This suggests that certain probiotics could be a safe dietary strategy to help counteract some of the negative health effects of microplastic exposure.
A probiotic for preventing microplastic toxicity: Clostridium dalinum mitigates microplastic-induced damage via microbiota-metabolism-barrier interactions
Using metagenomics and metabolomics, this study found that the probiotic bacterium Clostridium dalinum reduced microplastic-induced gut damage in mice by modulating gut microbiota composition, metabolic pathways, and intestinal barrier integrity.
Influence of Bisphenol a and Probiotic-containing Feedcarassius Gibelio Bloch Indicates Separately
This study examined how bisphenol A (BPA), a plastic monomer and hormone-disrupting chemical, affects the behavior, physiology, and health of a freshwater fish when administered in feed, and whether probiotic supplements could reduce these harmful effects. BPA is a widespread aquatic pollutant that enters waterways from plastic manufacturing and consumer product leaching.
Probiotics as Modulators of Microplastic-induced Toxicity: A Systematic Review
This systematic review found that probiotics can reduce microplastic-induced toxicity in animal models by restoring gut microbiota balance, reducing oxidative stress, and modulating inflammatory responses. The findings suggest that probiotic supplementation may help mitigate the harmful effects of unavoidable microplastic exposure, though human clinical trials are still needed.
Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis
The probiotic strain Lactiplantibacillus plantarum ZP-6 mitigated polystyrene nanoplastic-induced liver injury in an animal model through multiple mechanisms including toxin binding, barrier enhancement, and anti-inflammatory activity, suggesting probiotics as a potential strategy for reducing nanoplastic health impacts.
Polystyrene Nanoplastics Toxicity to Zebrafish: Dysregulation of the Brain–Intestine–Microbiota Axis
This study found that polystyrene nanoplastics disrupted the brain-gut connection in zebrafish at environmentally realistic concentrations, affecting growth, gut health, and brain chemistry. The nanoplastics altered neurotransmitter levels, particularly reducing a dopamine-related compound, and changed the balance of gut bacteria in ways that correlated with brain changes. These findings suggest a pathway by which nanoplastics in food and water could affect both digestive and brain health through the gut-brain axis.
Effects of MP Polyethylene Microparticles on Microbiome and Inflammatory Response of Larval Zebrafish
Zebrafish larvae exposed to polyethylene microplastics for up to 10 days showed no broad metabolic disturbances or inflammatory changes, but oxidative stress markers increased at 15 days and the gut microbiome was disrupted, with higher levels of bacteria linked to intestinal disease. The findings suggest microplastics alter the microbial environment of fish guts without triggering obvious inflammation.
Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics
Researchers engineered a probiotic-based system using modified E. coli Nissle 1917 bacteria to counteract gut barrier damage caused by nanoplastics derived from PET food packaging. The engineered probiotic was designed to produce an anti-inflammatory protein and was coated for better survival in the digestive tract, where it reduced inflammation, restored gut barrier function, and rebalanced gut bacteria in animal models. The study suggests that engineered probiotics could be a promising approach for protecting the gut from nanoplastic-related damage.
Systemic toxicity of biodegradable polyglycolic acid microplastics on the gut-liver-brain axis in zebrafish
Zebrafish exposed to polyglycolic acid (PGA) microplastics, a type of biodegradable plastic used in medical devices and food packaging, showed damage across the gut, liver, and brain through the gut-liver-brain axis. The microplastics increased gut permeability, disrupted beneficial gut bacteria, interfered with liver fat metabolism, and caused anxiety-like behavior and cognitive impairment. This study is notable because it shows that even biodegradable plastics can cause significant toxic effects when they break down into microplastics.
The Alleviative Effects of Weizmannia coagulans CGMCC 9951 on the Reproductive Toxicity of Caenorhabditis elegans Induced by Polystyrene Microplastics
Researchers tested whether a probiotic strain called Weizmannia coagulans could reduce the reproductive harm caused by polystyrene microplastics in a laboratory worm model. They found that the probiotic improved reproductive outcomes by boosting antioxidant defenses and reducing DNA damage in the worms' reproductive cells. The study suggests that certain probiotics may help counteract some of the reproductive toxicity associated with microplastic exposure.
Phthalates released from microplastics inhibit microbial metabolic activity and induce different effects on intestinal luminal and mucosal microbiota
Researchers used a simulated human gut model to show that intestinal microbiota accelerates the release of phthalate plasticizers from microplastics, and these released phthalates inhibit microbial metabolic activity and differentially affect luminal versus mucosal gut bacteria.
The zebrafish gut microbiome influences benzo[a]pyrene developmental neurotoxicity
Researchers found that the gut microbiome of zebrafish influences developmental neurotoxicity caused by benzo[a]pyrene, a polycyclic aromatic hydrocarbon, showing that microbial community composition modifies how the host responds to early-life toxicant exposure. The study highlighted gut-brain axis interactions as an important dimension of environmental toxicology.
Novel probiotics adsorbing and excreting microplastics in vivo show potential gut health benefits
Researchers screened 784 bacterial strains and identified two probiotic strains that can stick to microplastic particles in the gut and help remove them from the body. In mice, these probiotics increased microplastic excretion by 34% and reduced the amount of plastic remaining in the intestine by 67%. This is the first study to show that specific probiotics could help the body get rid of ingested microplastics and reduce gut inflammation caused by them.
Acute polyethylene microplastic (PE-MPs) exposure activates the intestinal mucosal immune network pathway in adult zebrafish (Danio rerio)
Researchers exposed adult zebrafish to polyethylene microplastics at various concentrations for seven days and examined intestinal immune responses. They found that higher concentrations reduced protective goblet cells and significantly altered the gut microbiome, increasing potentially harmful bacteria like Acinetobacter and Pseudomonas. The study suggests that microplastic exposure activates the intestinal immune network through disruption of the gut microbial community.
Micro-nanoplastics inhibit extracellular polymeric substance and lactate synthesis via perturbing glucose metabolism of Lacticaseibacillus rhamnosus
Researchers found that micro- and nanoplastics — especially nanoscale PET particles — impair the probiotic bacterium Lactobacillus rhamnosus by disrupting central carbon metabolism, reducing its production of lactic acid and protective extracellular polysaccharides, raising concerns that microplastic ingestion could compromise the gut benefits of probiotic bacteria.
New insight into long-term effects of phthalates microplastics in developing zebrafish: Evidence from genomic alteration and organ development
Researchers investigated the long-term developmental effects of three common plasticizers (DBP, DEP, and DEHP) leaching from microplastics on zebrafish larvae. The study found that phthalate exposure caused higher mortality, morphological abnormalities, and significant changes in genes related to cardiovascular development, tail formation, and other critical developmental pathways.
Vitamin D modulation of brain-gut-virome disorder caused by polystyrene nanoplastics exposure in zebrafish (Danio rerio)
In zebrafish exposed to polystyrene nanoplastics, a vitamin D-rich diet reduced nanoplastic accumulation in the brain by 20% and in the intestine by over 50%, while also reducing anxiety-like behavior. The nanoplastics disrupted the gut-brain connection by altering intestinal viruses, but vitamin D helped counteract these effects. This study suggests that adequate vitamin D intake might help protect against some of the harmful effects of nanoplastic exposure on the brain and gut.